Research map: Indoxyl sulfate exacerbates chronic inflammation and susceptibility to severe infection via modulating T-cell CD73/adenosine signaling in chronic kidney disease

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  1. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression · Silvia Deaglio · 2007 · 2468 citations · Cited by this paper
  2. Predictive modeling of fluid status in hemodialysis: model development and internal validation using the MONitoring dialysis outcomes (MONDO) global database · 2026 · Related
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  13. Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during Hypoxia · Linda F. Thompson · 2004 · 554 citations · Cited by this paper
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  19. Purinergic Signalling: Pathophysiological Roles · Maria P. Abbracchio · 1998 · 446 citations · Cited by this paper
  20. Development and validation of a dual-channel deep learning for continuous acute kidney injury prediction in critically ill patients · 2026 · Related
  21. Immune Dysfunction and Risk of Infection in Chronic Kidney Disease · Maaz Syed-Ahmed · 2019 · 426 citations · Cited by this paper
  22. Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023 · Patrick B Mark · 2025 · 378 citations · Cited by this paper
  23. CD73: a potent suppressor of antitumor immune responses · Paul A. Beavis · 2012 · 370 citations · Cited by this paper
  24. Mechanisms of ATP Release by Inflammatory Cells · Michel Dosch · 2018 · 284 citations · Cited by this paper
  25. Loss of ATP Diphosphohydrolase Activity with Endothelial Cell Activation · Simon Christopher Robson · 1997 · 283 citations · Cited by this paper
  26. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free radical in proximal tubular cells · Masaru Motojima · 2003 · 276 citations · Cited by this paper
  27. Naïve and central memory T-cell lymphopenia in end-stage renal disease · Jong‐Woo Yoon · 2006 · 194 citations · Cited by this paper
  28. NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells · Hidehisa Shimizu · 2011 · 177 citations · Cited by this paper
  29. Role of Uremic Toxins for Kidney, Cardiovascular, and Bone Dysfunction · Hideki Fujii · 2018 · 141 citations · Cited by this paper
  30. CD73‐generated adenosine promotes osteoblast differentiation · Masahide Takedachi · 2011 · 123 citations · Cited by this paper
  31. Indoxyl Sulfate Reduces Superoxide Scavenging Activity in the Kidneys of Normal and Uremic Rats · Shigeru Owada · 2007 · 110 citations · Cited by this paper
  32. Pro-Inflammatory Effects of Indoxyl Sulfate in Mice: Impairment of Intestinal Homeostasis and Immune Response · Shara Francesca Rapa · 2021 · 63 citations · Cited by this paper
  33. Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate · Eric G. Devine · 2014 · 62 citations · Cited by this paper
  34. The volatile anesthetic isoflurane induces ecto-5′-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury · Mihwa Kim · 2013 · 61 citations · Cited by this paper
  35. The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy · Xuan Jiang · 2023 · 53 citations · Cited by this paper
  36. Intestinal immunopathology is associated with decreased CD73-generated adenosine during lethal infection · Vincent François · 2014 · 34 citations · Cited by this paper
  37. A new low-nephron CKD model with hypertension, progressive decline of renal function, and enhanced inflammation in C57BL/6 mice · Jin Wei · 2018 · 25 citations · Cited by this paper
  38. The CD39-CD73-adenosine axis: Master regulator of immune evasion and therapeutic target in pancreatic ductal adenocarcinoma · Xiaolong Liu · 2025 · 22 citations · Cited by this paper
  39. Lytic Release of Cellular ATP: Physiological Relevance and Therapeutic Applications · Ryszard Grygorczyk · 2021 · 21 citations · Cited by this paper

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