Research map: Overview of the DREADDs chemogenetics and the patent landscape of their actuators

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Papers in this map

  1. In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector · Luigi Naldini · 1996 · 4959 citations · Cited by this paper
  2. Small Molecule Insulin Sensitisers: New Leads and Targets for Next-Generation Insulin Sensitising Strategies · 2026 · Related
  3. A Third-Generation Lentivirus Vector with a Conditional Packaging System · Tom Dull · 1998 · 3415 citations · Cited by this paper
  4. Alisols A-C and their acetate derivatives: a review of natural occurrence, pharmacology, semisynthesis, pharmacokinetics, and metabolism · 2026 · Related
  5. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand · Blaine N. Armbruster · 2007 · 2180 citations · Cited by this paper
  6. Investigation of reported small molecule P2Y6 receptor antagonists · 2026 · Related
  7. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo · Romain Zufferey · 1997 · 2037 citations · Cited by this paper
  8. Discovery of 3-(N-phenylsulfamoyl)-l-phenylalanine derivatives as novel and orally available LAT1-selective inhibitors · 2026 · Related
  9. DREADDs for Neuroscientists · Bryan L. Roth · 2016 · 1862 citations · Cited by this paper
  10. From lipophilicity windows to decision-grade antibacterial design: the next translational step for coumarin amphiphiles · 2026 · Related
  11. Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery · Romain Zufferey · 1998 · 1834 citations · Cited by this paper
  12. Inactivation of ornithine aminotransferase by (1R,4S)-4-Amino-3-(trifluoromethyl)cyclopent-2-ene-1-carboxylic acid via a stable quinonoid intermediate · 2026 · Related
  13. Rapid, reversible activation of AgRP neurons drives feeding behavior in mice · Michael J. Krashes · 2011 · 1670 citations · Cited by this paper
  14. Characterization of beddomeilactone amide as bacterial DNA gyrase inhibitor: in vitro evaluation and computational insights · 2026 · Related
  15. Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection · Carmela Zincarelli · 2008 · 1539 citations · Cited by this paper
  16. Synthesis and antihepatoma activity of dimeric 1-O-acetylbritannilactone derivatives · 2026 · Related
  17. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. · Jane C. Burns · 1993 · 1408 citations · Cited by this paper
  18. Unrevealing the Role of Flavonoids in Mitigation of Non-Alcoholic Fatty Liver Disease · 2026 · Related
  19. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine · Juan L. Gomez · 2017 · 1074 citations · Cited by this paper
  20. DREADDs‐Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons · 2025 · Related
  21. Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity · Katharina Timper · 2017 · 813 citations · Cited by this paper
  22. Pavlovian conditioning–induced hallucinations result from overweighting of perceptual priors · Albert R. Powers · 2017 · 759 citations · Cited by this paper
  23. DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility · Daniel J. Urban · 2014 · 710 citations · Cited by this paper
  24. LDL receptor and its family members serve as the cellular receptors for vesicular stomatitis virus · Danit Finkelshtein · 2013 · 674 citations · Cited by this paper
  25. The Role of Neural Plasticity in Depression: From Hippocampus to Prefrontal Cortex · Wei Liu · 2017 · 658 citations · Cited by this paper
  26. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger · Michael J. Krashes · 2014 · 648 citations · Cited by this paper
  27. Quantitative Analysis of the Packaging Capacity of Recombinant Adeno-Associated Virus · Jian-Yun Dong · 1996 · 592 citations · Cited by this paper
  28. Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. · S F Yu · 1986 · 546 citations · Cited by this paper
  29. Altering the Tropism of Lentiviral Vectors through Pseudotyping · J. Cronin · 2005 · 545 citations · Cited by this paper
  30. Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse · David A. Williams · 1984 · 536 citations · Cited by this paper
  31. Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells. · Paul L. Hermonat · 1984 · 482 citations · Cited by this paper
  32. Neurons Are Recruited to a Memory Trace Based on Relative Neuronal Excitability Immediately before Training · Adelaide P. Yiu · 2014 · 471 citations · Cited by this paper
  33. Systematic Determination of the Packaging Limit of Lentiviral Vectors · Mukesh Kumar · 2001 · 459 citations · Cited by this paper
  34. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys · Yuji Nagai · 2020 · 458 citations · Cited by this paper
  35. Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area · Sebastian Kügler · 2003 · 431 citations · Cited by this paper
  36. Rabies virus glycoprotein pseudotyping of lentiviral vectors enables retrograde axonal transport and access to the nervous system after peripheral delivery · Nicholas D. Mazarakis · 2001 · 428 citations · Cited by this paper
  37. Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain · Cassia N. Cearley · 2006 · 412 citations · Cited by this paper
  38. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior · Eyal Vardy · 2015 · 407 citations · Cited by this paper
  39. Inhibition of Mediodorsal Thalamus Disrupts Thalamofrontal Connectivity and Cognition · Sébastien Parnaudeau · 2013 · 407 citations · Cited by this paper

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