Research map: Glucagon-like peptide-1 and peptide YY multi-agonism with GEP44 to optimize weight loss and glycemic control while reducing gastrointestinal side effects: the future of anti-obesity pharmacotherapy?

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  1. Once-Weekly Semaglutide in Adults with Overweight or Obesity · John P.H. Wilding · 2021 · 5054 citations · Cited by this paper
  2. Subclinical primary aldosteronism: toward a conceptual framework linking primary aldosteronism and low-renin hypertension · 2026 · Related
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  4. Physician and hospital determinants of levothyroxine treatment adequacy in low-risk papillary thyroid carcinoma · 2026 · Related
  5. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management · Xavier Pi-Sunyer · 2015 · 2707 citations · Cited by this paper
  6. The effects of SARS-CoV-2 on bone homeostasis · 2026 · Related
  7. Gut hormone PYY3-36 physiologically inhibits food intake · Rachel Louise Batterham · 2002 · 2363 citations · Cited by this paper
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  9. Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36 · Rachel Louise Batterham · 2003 · 1611 citations · Cited by this paper
  10. Association between metabolic syndrome and mortality among breast cancer survivors: a prospective cohort study · 2026 · Related
  11. Human distribution and release of a putative new gut hormone, peptide YY · Thomas Edward Adrian · 1985 · 1073 citations · Cited by this paper
  12. Association of accelerometer-measured physical activity and the risk of incident cardiovascular diseases within the AHA cardiovascular-kidney-metabolic syndrome 0–4 framework: a prospective cohort of the UK Biobank · 2026 · Related
  13. Glucagon-like peptide-1 receptor: mechanisms and advances in therapy · Zhikai Zheng · 2024 · 982 citations · Cited by this paper
  14. Association of gravidity, parity, and abortion history with nodal metastasis in women with papillary thyroid carcinoma: a retrospective cohort study · 2026 · Related
  15. Pharmacology, Physiology, and Mechanisms of Action of Dipeptidyl Peptidase-4 Inhibitors · Erin E. Mulvihill · 2014 · 626 citations · Cited by this paper
  16. Association between primary aldosteronism and type 2 diabetes and identification of potential molecular mechanisms · 2026 · Related
  17. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis · Peter D. Holzer · 2012 · 506 citations · Cited by this paper
  18. Effects of Glucagon‐Like Peptide‐1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review · 2026 · Related
  19. GLP-1 physiology informs the pharmacotherapy of obesity · Daniel J. Drucker · 2021 · 502 citations · Cited by this paper
  20. Triple Agonism Based Therapies for Obesity · 2025 · Related
  21. Anti-obesity drugs: past, present and future · R. John Rodgers · 2012 · 440 citations · Cited by this paper
  22. The role of proopiomelanocortin (POMC) neurones in feeding behaviour · George W. M. Millington · 2007 · 357 citations · Cited by this paper
  23. The role of peptide YY in appetite regulation and obesity · Efthimia Karra · 2008 · 338 citations · Cited by this paper
  24. Targeting GLP-1 receptor trafficking to improve agonist efficacy · Ben J. Jones · 2018 · 302 citations · Cited by this paper
  25. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice · Amanda Sainsbury · 2002 · 249 citations · Cited by this paper
  26. Effects of PYY1–36and PYY3–36on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects · Birgitte Sloth · 2006 · 245 citations · Cited by this paper
  27. The Role of GLP-1 in the Metabolic Success of Bariatric Surgery · Chelsea R. Hutch · 2017 · 238 citations · Cited by this paper
  28. Effects of Exenatide and Lifestyle Modification on Body Weight and Glucose Tolerance in Obese Subjects With and Without Pre-Diabetes · Julio Rosenstock · 2010 · 231 citations · Cited by this paper
  29. The role of NPY in hypothalamic mediated food intake · Rebecca E. Mercer · 2011 · 207 citations · Cited by this paper
  30. Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis · Paschalis Karakasis · 2024 · 205 citations · Cited by this paper
  31. The L-cell in nutritional sensing and the regulation of appetite · Eleanor Spreckley · 2015 · 197 citations · Cited by this paper
  32. Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency · Mohamad Mokadem · 2013 · 176 citations · Cited by this paper
  33. Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine · Emily W. L. Sun · 2017 · 153 citations · Cited by this paper
  34. Effects of PYY3–36 and GLP-1 on energy intake, energy expenditure, and appetite in overweight men · Julie Berg Schmidt · 2014 · 145 citations · Cited by this paper
  35. Peptide YY 3-36 Inhibits Both Anorexigenic Proopiomelanocortin and Orexigenic Neuropeptide Y Neurons: Implications for Hypothalamic Regulation of Energy Homeostasis · Claudio Acuna · 2005 · 121 citations · Cited by this paper
  36. Identification and Distribution of mRNA Encoding the Y1, Y2, Y4, and Y5 Receptors for Peptides of the PP-fold Family in the Rat Intestine and Colon · Mathieu Goumain · 1998 · 105 citations · Cited by this paper
  37. Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3–36 Levels · Blanca Oliván · 2009 · 104 citations · Cited by this paper
  38. Loss of dorsomedial hypothalamic GLP-1 signaling reduces BAT thermogenesis and increases adiposity · Shin J. Lee · 2018 · 97 citations · Cited by this paper
  39. PYY plays a key role in the resolution of diabetes following bariatric surgery in humans · Claudia Guida · 2019 · 97 citations · Cited by this paper

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