Research map: Helicase-primase inhibitors as next-generation anti-HSV agents: from current clinical status to structure-activity relationships and patent coverage

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  1. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease · Ruth F. Itzhaki · 1997 · 678 citations · Cited by this paper
  2. Susceptibility of clinical isolates, laboratory-adapted and drug-resistant herpes simplex virus strains to helicase-primase inhibitor adibelivir (IM-250) and its synergy in combination therapy with acyclovir, penciclovir and foscarnet · Christian Gege · 2026 · Cites this paper
  3. Sirtuin modulators: a review of patents from 2020 to 2024 · 2025 · Related
  4. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease · Gerald Kleymann · 2002 · 334 citations · Cited by this paper
  5. A patent review of Mpro protease inhibitors for the treatment of COVID-19 infections (2020 – present) · 2025 · Related
  6. Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease · James J. Crute · 2002 · 234 citations · Cited by this paper
  7. Therapeutic applications of benzoxaborole compounds: a patent and literature analysis (2019–2024) · 2025 · Related
  8. Herpes simplex virus 1 helicase-primase: a complex of three herpes-encoded gene products. · James J. Crute · 1989 · 231 citations · Cited by this paper
  9. An updated patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2020–2025) · 2026 · Related
  10. Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection · Anna Wald · 2014 · 175 citations · Cited by this paper
  11. 5’-Ectonucleotidase (CD73) inhibitors: a patent review (2021-present) · 2026 · Related
  12. Antiviral Therapies for Herpesviruses: Current Agents and New Directions · Claudette L. Poole · 2018 · 172 citations · Cited by this paper
  13. PCSK9 inhibitors: an updated patent review 2024–2025 · 2026 · Related
  14. ASP2151, a novel helicase-primase inhibitor, possesses antiviral activity against varicella-zoster virus and herpes simplex virus types 1 and 2 · Koji Chono · 2010 · 165 citations · Cited by this paper
  15. Topoisomerase II inhibitors in oncology: an updated patent review (2016-present) · 2025 · Related
  16. Potent In Vivo Antiviral Activity of the Herpes Simplex Virus Primase-Helicase Inhibitor BAY 57-1293 · Ulrich A. K. Betz · 2002 · 135 citations · Cited by this paper
  17. A novel inhibitor of human cytomegalovirus acts through a specific antiviral mechanism that involves the helicase-primase complex · 2026 · Related
  18. Overwhelming Evidence for a Major Role for Herpes Simplex Virus Type 1 (HSV1) in Alzheimer’s Disease (AD); Underwhelming Evidence against · Ruth F. Itzhaki · 2021 · 127 citations · Cited by this paper
  19. Evaluation of the patent portfolio for helicase-primase inhibitor ABI-5366 of Assembly Biosciences Inc · 2025 · Related
  20. Inhibition of Herpes Simplex Virus Replication by a 2-Amino Thiazole via Interactions with the Helicase Component of the UL5-UL8-UL52 Complex · F. Spector · 1998 · 122 citations · Cited by this paper
  21. Effect of Pritelivir Compared With Valacyclovir on Genital HSV-2 Shedding in Patients With Frequent Recurrences · Anna Wald · 2016 · 110 citations · Cited by this paper
  22. Talimogene Laherparepvec: Review of its Mechanism of Action and Clinical Efficacy and Safety · Steven S. Raman · 2019 · 101 citations · Cited by this paper
  23. ASP2151 for the Treatment of Genital Herpes: A Randomized, Double-Blind, Placebo- and Valacyclovir-Controlled, Dose-Finding Study · Stephen Keith Tyring · 2012 · 90 citations · Cited by this paper
  24. Estimated global and regional incidence and prevalence of herpes simplex virus infections and genital ulcer disease in 2020: mathematical modelling analyses · Manale Harfouche · 2024 · 90 citations · Cited by this paper
  25. Amenamevir, a Helicase-Primase Inhibitor, for the Optimal Treatment of Herpes Zoster · Kimiyasu Shiraki · 2021 · 88 citations · Cited by this paper
  26. Amenamevir, a novel helicase–primase inhibitor, for treatment of herpes zoster: A randomized, double‐blind, valaciclovir‐controlled phase 3 study · Makoto Kawashima · 2017 · 78 citations · Cited by this paper
  27. Valacyclovir for Herpes Simplex Encephalitis · Thomas Pouplin · 2011 · 75 citations · Cited by this paper
  28. Discovery, Chemistry, and Preclinical Development of Pritelivir, a Novel Treatment Option for Acyclovir-Resistant Herpes Simplex Virus Infections · Alexander Birkmann · 2022 · 56 citations · Cited by this paper
  29. Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design · Lewis D. Pennington · 2020 · 53 citations · Cited by this paper
  30. A helicase-primase drug candidate with sufficient target tissue exposure affects latent neural herpes simplex virus infections · Christian Gege · 2021 · 53 citations · Cited by this paper
  31. The DNA helicase–primase complex as a target for herpes viral infection · Sandra K. Weller · 2013 · 51 citations · Cited by this paper
  32. An updated review of HSV-1 infection-associated diseases and treatment, vaccine development, and vector therapy application · Dan Su · 2024 · 48 citations · Cited by this paper
  33. Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors · Andrea Angeli · 2023 · 42 citations · Cited by this paper
  34. Isolation and characterization of herpes simplex virus type 1 resistant to aminothiazolylphenyl-based inhibitors of the viral helicase-primase · Michel Liuzzi · 2004 · 40 citations · Cited by this paper
  35. Synergistic activity of amenamevir (ASP2151) with nucleoside analogs against herpes simplex virus types 1 and 2 and varicella-zoster virus · Koji Chono · 2012 · 38 citations · Cited by this paper
  36. The three-component helicase/primase complex of herpes simplex virus-1 · Oya Bermek · 2021 · 38 citations · Cited by this paper
  37. Overview on the management of herpes simplex virus infections: Current therapies and future directions · Alexander Birkmann · 2025 · 36 citations · Cited by this paper
  38. Oral Bioavailability and In Vivo Efficacy of the Helicase-Primase Inhibitor BILS 45 BS against Acyclovir-Resistant Herpes Simplex Virus Type 1 · Jianmin Duan · 2003 · 35 citations · Cited by this paper
  39. Profile of anti-herpetic action of ASP2151 (amenamevir) as a helicase-primase inhibitor · Misako Yajima · 2016 · 28 citations · Cited by this paper

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