Research map: Hippocampal remodeling in chronic pain: Structural, functional, cellular, metabolic, and molecular mechanisms and therapeutic perspectives

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Papers in this map

  1. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises · Srinivasa Naga Raja · 2020 · 5191 citations · Cited by this paper
  2. A multi-component intervention enhances intestinal urate excretion and improves metabolic and immune homeostasis in diet-induced hyperuricemia · 2026 · Related
  3. Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11) · Rolf‐Detlef Treede · 2018 · 3456 citations · Cited by this paper
  4. Targeting pulmonary vascular–alveolar coupling in bronchopulmonary dysplasia: Therapeutic mechanisms and translational prospects of extracellular vesicle-based drug delivery · 2026 · Related
  5. Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016 · James M. Dahlhamer · 2018 · 2664 citations · Cited by this paper
  6. Targeting RNA quality-control defects in tauopathies: Pharmacodynamic biomarkers and therapeutic development · 2026 · Related
  7. Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis · Amanda Sierra · 2010 · 1661 citations · Cited by this paper
  8. Neural and behavioral dynamics of acute fentanyl administration and implications for hazard assessment of novel synthetic opioids in larval zebrafish · 2026 · Related
  9. Prevalence of chronic pain in the UK: a systematic review and meta-analysis of population studies · Alan Fayaz · 2016 · 1388 citations · Cited by this paper
  10. Artesunate as an emerging anticancer modality: Insights and advances · 2026 · Related
  11. Synaptic Plasticity Forms and Functions · Jeffrey C. Magee · 2020 · 852 citations · Cited by this paper
  12. Harnessing edible extracellular vesicles for inflammatory bowel disease: From natural immunomodulators to bioengineered oral nanotherapeutics · 2026 · Related
  13. TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury · Yong Liu · 2016 · 391 citations · Cited by this paper
  14. Targeting ATP-citrate lyase across cardiometabolic and oncologic disease · 2026 · Related
  15. Peripheral Nerve Injury Leads to Working Memory Deficits and Dysfunction of the Hippocampus by Upregulation of TNF-α in Rodents · Wenjie Ren · 2011 · 241 citations · Cited by this paper
  16. Innate immune surveillance and nucleic acid sensing: Gatekeepers of inflammatory cell death in respiratory infectious diseases · 2026 · Related
  17. Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation/phagocytosis · Ben Bassett · 2020 · 223 citations · Cited by this paper
  18. Sinomenine regulates the AKT/FOXO3/GLUL pathway to inhibit pulmonary fibroblast-to-myofibroblast transition via α7nAChR against rheumatoid arthritis associated interstitial lung disease · 2026 · Related
  19. Reorganization of hippocampal functional connectivity with transition to chronic back pain · Amelia Mutso · 2013 · 193 citations · Cited by this paper
  20. The regulatory mechanisms of Indole-3-carboxaldehyde in immune cells and its role in autoimmune diseases · 2026 · Related
  21. Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling · Anna Dellarole · 2014 · 165 citations · Cited by this paper
  22. Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain · Emily P. Mills · 2017 · 146 citations · Cited by this paper
  23. Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia · Mak Adam Daulatzai · 2014 · 141 citations · Cited by this paper
  24. HMGB1 mediates synaptic loss and cognitive impairment in an animal model of sepsis-associated encephalopathy · Xiaoyu Yin · 2023 · 137 citations · Cited by this paper
  25. Adult Hippocampal Neurogenesis along the Dorsoventral Axis Contributes Differentially to Environmental Enrichment Combined with Voluntary Exercise in Alleviating Chronic Inflammatory Pain in Mice · Jie Zheng · 2017 · 120 citations · Cited by this paper
  26. Neurobiological Changes Induced by Mindfulness and Meditation: A Systematic Review · Andrea Calderone · 2024 · 112 citations · Cited by this paper
  27. Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study · Binlong Zhang · 2019 · 108 citations · Cited by this paper
  28. Anxiety-Like Behavior of Prenatally Stressed Rats Is Associated with a Selective Reduction of Glutamate Release in the Ventral Hippocampus · Jordan Marrocco · 2012 · 101 citations · Cited by this paper
  29. Major diencephalic inputs to the hippocampus · Robert P. Vertes · 2015 · 90 citations · Cited by this paper
  30. Hippocampal glutamatergic synapses impairment mediated novel-object recognition dysfunction in rats with neuropathic pain · Bingrui Xiong · 2020 · 83 citations · Cited by this paper
  31. Altered hippocampal long-term potentiation after peripheral nerve injury in mice · Daisuke Kodama · 2007 · 79 citations · Cited by this paper
  32. Electroacupuncture promotes synaptic plasticity in rats with chronic inflammatory pain–related depression by upregulating BDNF/TrkB/CREB signaling pathway · Pu Yang · 2023 · 78 citations · Cited by this paper
  33. Spontaneous Pain Disrupts Ventral Hippocampal CA1-Infralimbic Cortex Connectivity and Modulates Pain Progression in Rats with Peripheral Inflammation · Longyu Ma · 2019 · 74 citations · Cited by this paper
  34. MMPIP, an mGluR7-selective negative allosteric modulator, alleviates pain and normalizes affective and cognitive behavior in neuropathic mice · Enza Palazzo · 2015 · 73 citations · Cited by this paper
  35. Altered fMRI resting‐state connectivity in individuals with fibromyalgia on acute pain stimulation · Eric Ichesco · 2016 · 73 citations · Cited by this paper
  36. Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease · Stephanie A. Schultz · 2014 · 72 citations · Cited by this paper
  37. Chronic Pain Impairs Memory Formation via Disruption of Neurogenesis Mediated by Mesohippocampal Brain-Derived Neurotrophic Factor Signaling · Sun-Hui Xia · 2020 · 71 citations · Cited by this paper
  38. Cannabidiol effectively reverses mechanical and thermal allodynia, hyperalgesia, and anxious behaviors in a neuropathic pain model: Possible role of CB1 and TRPV1 receptors · Gleice Kelli Silva-Cardoso · 2021 · 68 citations · Cited by this paper
  39. The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy · Midiã Dias de Jesus Seno · 2018 · 67 citations · Cited by this paper

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