Research map: The orexin system as a pharmacological target in inflammation: peripheral mechanisms and safety implications

Papers in this map

1. Tissue-based map of the human proteome · Mathias Uhlén · 2015 · 16361 citations · Cited by this paper
2. Tislelizumab combined with Anti-GD2 antibody-based chemoimmunotherapy for pediatric relapsed/refractory high-risk neuroblastoma: a two-Case Report · 2026 · Related
3. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior · Takeshi Sakurai · 1998 · 5552 citations · Cited by this paper
4. Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development · 2026 · Related
5. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity · Luı́s de Lecea · 1998 · 3915 citations · Cited by this paper
6. A nomogram based on LASSO-logistic regression for predicting tocilizumab-associated hypofibrinogenemia in patients with rheumatic diseases · 2026 · Related
7. European guideline for the diagnosis and treatment of insomnia · Dieter Wilhelm Riemann · 2017 · 2103 citations · Cited by this paper
8. Traditional Chinese medicine interventions targeting Wnt/β-catenin signaling in cerebral ischemia/reperfusion injury: a review · 2026 · Related
9. A single–cell type transcriptomics map of human tissues · Max Karlsson · 2021 · 1916 citations · Cited by this paper
10. NSFC-funded Chinese materia medica research (2015–2024): achievements output, research characteristics, and evolution · 2026 · Related
11. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems · Yukari Date · 1999 · 1056 citations · Cited by this paper
12. Endothelial EPAS1 as a prognostic and therapeutic target in acute myocardial infarction: integrative bioinformatics, Mendelian randomization and experimental validation · 2026 · Related
13. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans · Jerrah K. Holth · 2019 · 837 citations · Cited by this paper
14. Hematopoietic and T-lymphopoiesis-stimulating effects of a fluorinated pyrazolopiperidine β-cyclodextrin complex in cyclophosphamide-induced hematopoietic suppression · 2026 · Related
15. The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation · Valentin A. Pavlov · 2003 · 770 citations · Cited by this paper
16. Ganhai Weikang Capsules ameliorate functional dyspepsia in rats by modulating gut microbiota and host metabolic homeostasis · 2026 · Related
17. Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis · Jared M. Huston · 2006 · 686 citations · Cited by this paper
18. Therapeutic potential of traditional Chinese medicine for hyperuricemia: mechanistic insights and clinical prospects · 2026 · Related
19. A genome-wide transcriptomic analysis of protein-coding genes in human blood cells · Mathias Uhlén · 2019 · 650 citations · Cited by this paper
20. Current and novel dual orexin receptor antagonists for the treatment of insomnia: the emergence of vornorexant · 2025 · Related
21. The CB2 receptor and its role as a regulator of inflammation · Caroline Turcotte · 2016 · 606 citations · Cited by this paper
22. The Effects of Serotonin in Immune Cells · Nadine Herr · 2017 · 518 citations · Cited by this paper
23. Immune Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis during Viral Infection · Marni N. Silverman · 2005 · 510 citations · Cited by this paper
24. The sympathetic nervous response in inflammation · Georg Pongratz · 2014 · 434 citations · Cited by this paper
25. Rethinking inflammation: neural circuits in the regulation of immunity · Peder S. Olofsson · 2012 · 401 citations · Cited by this paper
26. The cholinergic anti-inflammatory pathway: A critical review · Davide Martelli · 2013 · 387 citations · Cited by this paper
27. Effect of sleep on overnight cerebrospinal fluid amyloid β kinetics · Brendan P. Lucey · 2017 · 374 citations · Cited by this paper
28. Orexin A but Not Orexin B Rapidly Enters Brain from Blood by Simple Diffusion · Abba J. Kastin · 1999 · 325 citations · Cited by this paper
29. Centrally administered orexin/hypocretin activates HPA axis in rats · Makiko Kuru · 2000 · 288 citations · Cited by this paper
30. Possible Involvement of Orexin in the Stress Reaction in Rats · Takanori Ida · 2000 · 271 citations · Cited by this paper
31. Neuronal regulation of immunity: why, how and where? · Maya Schiller · 2020 · 270 citations · Cited by this paper
32. Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates · Sam A. Deadwyler · 2007 · 265 citations · Cited by this paper
33. Safety and efficacy of daridorexant in patients with insomnia disorder: results from two multicentre, randomised, double-blind, placebo-controlled, phase 3 trials · Emmanuel Jean-Marie Mignot · 2022 · 252 citations · Cited by this paper
34. The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions · Ayumu Inutsuka · 2013 · 238 citations · Cited by this paper
35. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding · Miika V. Heinonen · 2005 · 233 citations · Cited by this paper
36. Orexin-1 Receptor-Cannabinoid CB1 Receptor Heterodimerization Results in Both Ligand-dependent and -independent Coordinated Alterations of Receptor Localization and Function · James Ellis · 2006 · 225 citations · Cited by this paper
37. The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases · Chunmei Wang · 2018 · 209 citations · Cited by this paper
38. Orexin/hypocretin receptor signalling cascades · Jyrki P. Kukkonen · 2013 · 204 citations · Cited by this paper
39. Hypersensitization of the Orexin 1 Receptor by the CB1 Receptor · Sandrine Hilairet · 2003 · 189 citations · Cited by this paper

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