Research map: Targeting TLR4 with ligustrazine and AT1R with telmisartan ameliorates diabetic kidney disease

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Papers in this map

  1. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 · Kanyin Liane Ong · 2023 · 4687 citations · Cited by this paper
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  11. Roles of the NLRP3 inflammasome in the pathogenesis of diabetic nephropathy · Yuan-ye Qiu · 2016 · 195 citations · Cited by this paper
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  13. Inflammasome, Inflammation, and Tissue Homeostasis · Vijay A. K. Rathinam · 2018 · 195 citations · Cited by this paper
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  15. Diabetic kidney disease: An overview of prevalence, risk factors, and biomarkers · Salman Hussain · 2020 · 158 citations · Cited by this paper
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  17. Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance · Junyan Wang · 2025 · 134 citations · Cited by this paper
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  19. Proceedings of the 2025 2nd International Conference on Civil Engineering Structures and Concrete Materials (CESCM 2025) · 2025 · 133 citations · Cited by this paper
  20. Circ-PHC3 promotes malignant progression of ovarian cancer through regulating miR-512-3p/SLC2A1/HK2 mediated glucose metabolism · 2026 · Related
  21. TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition · Claire Elizabeth Hills · 2012 · 107 citations · Cited by this paper
  22. Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease · Ruixue Dong · 2023 · 94 citations · Cited by this paper
  23. Exploring inflammatory and fibrotic mechanisms driving diabetic nephropathy progression · Zarbakht Ansari Pirsaraei · 2025 · 82 citations · Cited by this paper
  24. Ligustrazine monomer against cerebral ischemia/reperfusion injury · Haijun Gao · 2015 · 79 citations · Cited by this paper
  25. TLR9 regulates NLRP3 inflammasome activation via the NF-kB signaling pathway in diabetic nephropathy · Jin-feng Shen · 2022 · 79 citations · Cited by this paper
  26. A plasma creatinine- and urea-based equation to estimate glomerular filtration rate in rats · Paul J. Besseling · 2021 · 76 citations · Cited by this paper
  27. Expression and cellular distribution of TLR4, MyD88, and NF-κB in diabetic renal tubulointerstitial fibrosis, in vitro and in vivo · Ping Liu · 2014 · 70 citations · Cited by this paper
  28. Comprehensive advancements in the prevention and treatment of diabetic nephropathy: A narrative review · Chukwuka Elendu · 2023 · 63 citations · Cited by this paper
  29. Protective effect of berberine on renal fibrosis caused by diabetic nephropathy · Li Zhong · 2017 · 53 citations · Cited by this paper
  30. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells · Xuezhong Gong · 2015 · 52 citations · Cited by this paper
  31. Tetramethylpyrazine prevents diabetes by activating PI3K/Akt/GLUT-4 signalling in animal model of type-2 diabetes · Uddipak Rai · 2019 · 47 citations · Cited by this paper
  32. Revisiting inflammation in diabetic nephropathy: the role of the Nlrp3 inflammasome in glomerular resident cells · Norihiko Sakai · 2014 · 46 citations · Cited by this paper
  33. Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-κB and Nrf-2/HO-1 pathways · Yongji Li · 2018 · 36 citations · Cited by this paper
  34. Effects of Ligustrazine on Ureteral Obstruction‐induced Renal Tubulointerstitial Fibrosis · Xiao‐peng Yuan · 2011 · 35 citations · Cited by this paper
  35. Ligustrazine Exerts Cardioprotection in Animal Models of Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms · Qun Zheng · 2018 · 34 citations · Cited by this paper
  36. Liraglutide ameliorates inflammation and fibrosis by downregulating the TLR4/MyD88/NF-κB pathway in diabetic kidney disease · Linjing Huang · 2024 · 31 citations · Cited by this paper
  37. Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways · Ahmed Mohamed Bahgat Awad · 2023 · 30 citations · Cited by this paper
  38. Renoprotective effect of esculetin against ischemic acute kidney injury-diabetic comorbidity · Neha Dagar · 2024 · 30 citations · Cited by this paper
  39. Diabetic Kidney Disease · Anna R. Gaddy · 2025 · 30 citations · Cited by this paper

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