Research map: Physical activity and human IAPP islet amyloidosis: mechanistic plausibility, missing evidence, and future directions

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  1. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin · Diabetes Prevention Program Research Group · 2002 · 19195 citations · Cited by this paper
  2. From developmental blueprint to adult physiological control: expanding roles of Otp in neuroendocrine regulation · 2026 · Related
  3. β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes · Alexandra E. Butler · 2003 · 4025 citations · Cited by this paper
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  5. Physical Activity/Exercise and Diabetes: A Position Statement of the American Diabetes Association · Sheri R. Colberg · 2016 · 3012 citations · Cited by this paper
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  7. Exercise and Type 2 Diabetes · Sheri R. Colberg · 2010 · 1972 citations · Cited by this paper
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  9. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes · Seth Lucian Masters · 2010 · 1338 citations · Cited by this paper
  10. MetaboMiNR: a redstone MiNRcraft tool for nuclear receptors and metabolism · 2026 · Related
  11. Muscle–Organ Crosstalk: The Emerging Roles of Myokines · Mai Charlotte Krogh Severinsen · 2020 · 1203 citations · Cited by this paper
  12. Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats · 2026 · Related
  13. Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus · Per Westermark · 2011 · 1060 citations · Cited by this paper
  14. Acidic extracellular pH-induced PTH secretion in male mouse parathyroids is OGR1-dependent · 2026 · Related
  15. Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice · Orly Lazarov · 2005 · 891 citations · Cited by this paper
  16. Generation and utility of endocrine functional testicular organoids · 2026 · Related
  17. Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis · Leena Haataja · 2008 · 618 citations · Cited by this paper
  18. Hormone-dependent mitochondrial resilience in leiomyoma cells exposed to oxidative stress · 2026 · Related
  19. Strength Training Increases Insulin-Mediated Glucose Uptake, GLUT4 Content, and Insulin Signaling in Skeletal Muscle in Patients With Type 2 Diabetes · Mads Holten · 2004 · 612 citations · Cited by this paper
  20. Bmal1 regulates thermogenic function by modulation of lipolytic and oxidative phosphorylation gene expression in male mice brown adipocytes · 2026 · Related
  21. Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs · Débora da Luz Scheffer · 2020 · 496 citations · Cited by this paper
  22. High Expression Rates of Human Islet Amyloid Polypeptide Induce Endoplasmic Reticulum Stress–Mediated β-Cell Apoptosis, a Characteristic of Humans With Type 2 but Not Type 1 Diabetes · Chang-jiang Huang · 2007 · 418 citations · Cited by this paper
  23. Amylin: Pharmacology, Physiology, and Clinical Potential · Debbie L. Hay · 2015 · 398 citations · Cited by this paper
  24. β-Cell Loss and β-Cell Apoptosis in Human Type 2 Diabetes Are Related to Islet Amyloid Deposition · Catherine A. Jurgens · 2011 · 331 citations · Cited by this paper
  25. Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology · Rehana Akter · 2015 · 274 citations · Cited by this paper
  26. Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy · Elisabetta Ferraro · 2014 · 269 citations · Cited by this paper
  27. Evidence for Proteotoxicity in β Cells in Type 2 Diabetes · Tatyana Gurlo · 2009 · 235 citations · Cited by this paper
  28. AMPK and the Adaptation to Exercise · Hannah Rose Spaulding · 2022 · 221 citations · Cited by this paper
  29. Islet inflammation in type 2 diabetes · Marianne Böni‐Schnetzler · 2019 · 215 citations · Cited by this paper
  30. Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity · Jacqueline F. Rivera · 2014 · 212 citations · Cited by this paper
  31. Mechanisms of islet amyloidosis toxicity in type 2 diabetes · Andisheh Abedini · 2013 · 204 citations · Cited by this paper
  32. Islet amyloid polypeptide and type 2 diabetes · Lucy Marzban · 2003 · 204 citations · Cited by this paper
  33. IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction · Clara Y. Westwell-Roper · 2011 · 192 citations · Cited by this paper
  34. The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation‐Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management · Maurício da Silva Krause · 2015 · 182 citations · Cited by this paper
  35. Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? · Sakeneh Zraika · 2010 · 182 citations · Cited by this paper
  36. Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice · Audrey Jalabert · 2016 · 180 citations · Cited by this paper
  37. Impairment of the Ubiquitin-Proteasome Pathway Is a Downstream Endoplasmic Reticulum Stress Response Induced by Extracellular Human Islet Amyloid Polypeptide and Contributes to Pancreatic β-Cell Apoptosis · Sı́lvia Casas · 2007 · 149 citations · Cited by this paper
  38. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial · Marja A. Heiskanen · 2018 · 141 citations · Cited by this paper
  39. Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP · Michele F. M. Sciacca · 2018 · 137 citations · Cited by this paper

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