Research map: Development, applications, and future prospects of RNA virus reverse genetics technology

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Papers in this map

  1. A pneumonia outbreak associated with a new coronavirus of probable bat origin · Peng Zhou · 2020 · 23438 citations · Cited by this paper
  2. A comprehensive review of mycoviruses infecting the plant pathogenic fungus Rosellinia necatrix · 2025 · Related
  3. Multiplex Genome Engineering Using CRISPR/Cas Systems · Le Cong · 2013 · 16042 citations · Cited by this paper
  4. Targeted virus-based catalase nanoreactors for potential acatalasemia treatment · 2026 · Related
  5. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine · Lindsey R. Baden · 2020 · 10909 citations · Cited by this paper
  6. Re-opening the question of lower SARS-CoV-2 attack rates in active smokers: a perspective on viral interference and Tobacco Mosaic Virus · 2026 · Related
  7. Structural basis of receptor recognition by SARS-CoV-2 · Jian Shang · 2020 · 4082 citations · Cited by this paper
  8. Virological surveillance of bats in Southern Kazakhstan · 2025 · Related
  9. Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates · Edward E. Walsh · 2020 · 2748 citations · Cited by this paper
  10. The spike S2 substitution, P804L, drives the adaptation of BANAL-20–236 to a broad range of Rhinolophus bat ACE2 · 2025 · Related
  11. Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19 · JERALD C. SADOFF · 2021 · 2624 citations · Cited by this paper
  12. Analytical performance evaluation of the EDELVITAL neutralizing antibody test in COVID-19-vaccinated staff of the University Dental Clinic Vienna · 2026 · Related
  13. Coronavirus envelope protein: current knowledge · Dewald Schoeman · 2019 · 2195 citations · Cited by this paper
  14. Microbiota-derived succinic acid boosts antiviral activity of AKT targeting in coronaviruses · 2026 · Related
  15. RNA targeting with CRISPR–Cas13 · Omar O. Abudayyeh · 2017 · 2194 citations · Cited by this paper
  16. A next-generation strategy for HIV-1 vaccination: computational design of a multi-epitope subunit vaccine targeting global circulating variants · 2026 · Related
  17. SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract · Yixuan Jacob Hou · 2020 · 1680 citations · Cited by this paper
  18. Bridging the gap: addressing real-life challenges to the implementation of DTG/3TC in treatment-naive people living with HIV · 2026 · Related
  19. A DNA transfection system for generation of influenza A virus from eight plasmids · Erich Hoffmann · 2000 · 1662 citations · Cited by this paper
  20. Efficient and modular reverse genetics system for rapid generation of recombinant severe acute respiratory syndrome coronavirus 2 · 2025 · Related
  21. The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity · Qianqian Li · 2020 · 1644 citations · Cited by this paper
  22. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein · Alexandra C. Walls · 2020 · 1496 citations · Cited by this paper
  23. Rescue of Influenza A Virus from Recombinant DNA · Ervin Fodor · 1999 · 800 citations · Cited by this paper
  24. Rescue of Newcastle Disease Virus from Cloned cDNA: Evidence that Cleavability of the Fusion Protein Is a Major Determinant for Virulence · Ben P. H. Peeters · 1999 · 500 citations · Cited by this paper
  25. Amplification, expression, and packaging of a foreign gene by influenza virus · Willem Luytjes · 1989 · 443 citations · Cited by this paper
  26. Oseltamivir (Tamiflu®) and its potential for use in the event of an influenza pandemic · Penelope Ward · 2005 · 434 citations · Cited by this paper
  27. Programmable Inhibition and Detection of RNA Viruses Using Cas13 · Catherine A. Freije · 2019 · 415 citations · Cited by this paper
  28. A novel transcription property of SP6 and T7 RNA polymerases: dependence on template structure · Elaine T. Schenborn · 1985 · 273 citations · Cited by this paper
  29. The Hemagglutinin-Neuraminidase Protein of Newcastle Disease Virus Determines Tropism and Virulence · Zhuhui Huang · 2004 · 250 citations · Cited by this paper
  30. SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling pathways · Lulu Han · 2021 · 249 citations · Cited by this paper
  31. Self-coded 3′-Extension of Run-off Transcripts Produces Aberrant Products during in Vitro Transcription with T7 RNA Polymerase · Francisco J. Triana‐Alonso · 1995 · 215 citations · Cited by this paper
  32. Engineering SARS-CoV-2 using a reverse genetic system · Xuping Xie · 2021 · 215 citations · Cited by this paper
  33. RNA polymerase unwinds an 11-base pair segment of a phage T7 promoter · Ulrich K. Siebenlist · 1979 · 183 citations · Cited by this paper
  34. An improved reverse genetics system for influenza A virus generation and its implications for vaccine production · Gabriele Neumann · 2005 · 180 citations · Cited by this paper
  35. A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses · Alberto Anastacio Amarilla · 2021 · 180 citations · Cited by this paper
  36. Paxlovid (Nirmatrelvir/Ritonavir): A new approach to Covid-19 therapy? · Seyed Mohammad Reza Hashemian · 2023 · 176 citations · Cited by this paper
  37. Baloxavir Marboxil for Prophylaxis against Influenza in Household Contacts · Hideyuki Ikematsu · 2020 · 174 citations · Cited by this paper
  38. Reverse Genetics Approaches for the Development of Influenza Vaccines · Aitor Nogales · 2016 · 167 citations · Cited by this paper
  39. Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus · Adam Vigil · 2007 · 163 citations · Cited by this paper

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