Research map: Targeting Oncomucin-Driven Immunosuppression Improves the Efficacy of K-rasG12D Inhibition in Pancreatic Cancer

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  1. Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma · Junya Peng · 2019 · 1475 citations · Cited by this paper
  2. RAS signaling and remodeling of the immune microenvironment in pancreatic ductal adenocarcinoma: implications of emerging RAS-targeted therapy · Di Meng · 2026 · Cites this paper
  3. Building the Human Liver in a Dish: Organoids, Assembloids, and the Road to Precision Hepatology · 2026 · Related
  4. Molecular subtypes of pancreatic cancer · Eric Andrew Collisson · 2019 · 955 citations · Cited by this paper
  5. AGA Technical Review on Gastric Intestinal Metaplasia—Natural History and Clinical Outcomes · 2020 · Related
  6. Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor · Xiaolun Wang · 2021 · 756 citations · Cited by this paper
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  10. MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress · Mildred A. R. Felder · 2014 · 567 citations · Cited by this paper
  11. CME Exam 2: β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort · 2026 · Related
  12. Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment · William L. Hwang · 2022 · 438 citations · Cited by this paper
  13. Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport · 2026 · Related
  14. Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia · Florencia M. McAllister · 2014 · 413 citations · Cited by this paper
  15. Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data · 2020 · Related
  16. Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer · Minghai Zhang · 2021 · 399 citations · Cited by this paper
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  18. The EGFR pathway is involved in the regulation of PD-L1 expression via the IL-6/JAK/STAT3 signaling pathway in EGFR-mutated non-small cell lung cancer · Nan Zhang · 2016 · 393 citations · Cited by this paper
  19. Efficacy of a Small-Molecule Inhibitor of KrasG12D in Immunocompetent Models of Pancreatic Cancer · Samantha B. Kemp · 2022 · 383 citations · Cited by this paper
  20. Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions · Wei Lin · 2020 · 361 citations · Cited by this paper
  21. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer · Emad A. Rakha · 2005 · 350 citations · Cited by this paper
  22. Immature truncated O-glycophenotype of cancer directly induces oncogenic features · Prakash Radhakrishnan · 2014 · 333 citations · Cited by this paper
  23. Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma · Yunzhen Qian · 2020 · 317 citations · Cited by this paper
  24. Mucins in pancreatic cancer and its microenvironment · Sukhwinder Kaur · 2013 · 311 citations · Cited by this paper
  25. Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer · Julien Dilly · 2024 · 274 citations · Cited by this paper
  26. Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance · Yaqing Zhang · 2013 · 267 citations · Cited by this paper
  27. KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells · Krishnan K. Mahadevan · 2023 · 257 citations · Cited by this paper
  28. The belated US FDA approval of the adenosine A2A receptor antagonist istradefylline for treatment of Parkinson’s disease · Jiang‐Fan Chen · 2020 · 235 citations · Cited by this paper
  29. MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells · Jennifer A. A. Gubbels · 2010 · 213 citations · Cited by this paper
  30. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction · Chen Ying Zhu · 2015 · 211 citations · Cited by this paper
  31. Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis · Robert S. Bresalier · 1996 · 171 citations · Cited by this paper
  32. Pathobiological Implications of MUC16 Expression in Pancreatic Cancer · Dhanya Haridas · 2011 · 144 citations · Cited by this paper
  33. A Long-Term Study of Istradefylline Safety and Efficacy in Patients With Parkinson Disease · Tomoyoshi Kondo · 2015 · 140 citations · Cited by this paper
  34. Epithelial and stromal co-evolution and complicity in pancreatic cancer · Sunil R. Hingorani · 2022 · 114 citations · Cited by this paper
  35. Mucins and Pancreatic Cancer · Nicolas Jonckheere · 2010 · 94 citations · Cited by this paper
  36. Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells · Srustidhar Das · 2015 · 92 citations · Cited by this paper
  37. Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness · Koelina Ganguly · 2020 · 80 citations · Cited by this paper
  38. Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis · Seongryong Kim · 2024 · 72 citations · Cited by this paper
  39. Tumor necrosis factor-α and interferon-γ stimulate MUC16 (CA125) expression in breast, endometrial and ovarian cancers through NFκB · Micaela Morgado · 2016 · 64 citations · Cited by this paper

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