Research map: PPARγ suppresses the tumorigenesis of retroperitoneal liposarcoma via inactivation of the PI3K/AKT signaling pathway

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  1. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer · Antonino Glaviano · 2023 · 2116 citations · Cited by this paper
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  15. PI3K/AKT/mTOR Axis in Cancer: From Pathogenesis to Treatment · Mingyang Jiang · 2025 · 136 citations · Cited by this paper
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  17. MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma · Emily Kanaya Slotkin · 2014 · 97 citations · Cited by this paper
  18. Drug–drug interactions with pioglitazone, losartan, and midazolam and anti-tumor efficacy and safety study of TAS-115 in patients with solid tumors · 2026 · Related
  19. Use of a Metabolic Syndrome Severity Z Score to Track Risk During Treatment of Prediabetes: An Analysis of the Diabetes Prevention Program · Mark Daniel DeBoer · 2018 · 93 citations · Cited by this paper
  20. Imaging of Liposarcoma: Classification, Patterns of Tumor Recurrence, and Response to Treatment · Kevin N. O'Regan · 2011 · 82 citations · Cited by this paper
  21. A phase 1 study of efatutazone, an oral peroxisome proliferator‐activated receptor gamma agonist, administered to patients with advanced malignancies · Michael J. Pishvaian · 2012 · 68 citations · Cited by this paper
  22. Multiply recurrent retroperitoneal liposarcoma · Sanjay Prakash Bagaria · 2017 · 60 citations · Cited by this paper
  23. A Novel Antidiabetic Drug, Troglitazone — Reason for Hope and Concern · Hiroo Imura · 1998 · 59 citations · Cited by this paper
  24. Surgery for Abdominal Well-Differentiated Liposarcoma · Sara A. Mansfield · 2018 · 49 citations · Cited by this paper
  25. Anti-tumor effects of anti-PD-1 antibody, pembrolizumab, in humanized NSG PDX mice xenografted with dedifferentiated liposarcoma · Bongkum Choi · 2020 · 46 citations · Cited by this paper
  26. Phosphatidylinositol-3-kinase (PI3K)/Akt Signaling is Functionally Essential in Myxoid Liposarcoma · Marcel Trautmann · 2019 · 42 citations · Cited by this paper
  27. Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma · Ruth Berthold · 2022 · 37 citations · Cited by this paper
  28. Adapalene inhibits the growth of triple-negative breast cancer cells by S-phase arrest and potentiates the antitumor efficacy of GDC-0941 · Umar Mehraj · 2022 · 36 citations · Cited by this paper
  29. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer · Megumi Fujita · 2017 · 33 citations · Cited by this paper
  30. Phase II Clinical Trial of Eribulin–Gemcitabine Combination Therapy in Previously Treated Patients With Advanced Liposarcoma or Leiomyosarcoma · Chang Gon Kim · 2022 · 32 citations · Cited by this paper
  31. Retroperitoneal Soft Tissue Sarcoma: Emerging Therapeutic Strategies · Eelco de Bree · 2023 · 30 citations · Cited by this paper
  32. PPARγ activation by troglitazone enhances human lung cancer cells to TRAIL-induced apoptosis via autophagy flux · Uddin Md. Nazim · 2017 · 27 citations · Cited by this paper
  33. PPARγ sumoylation-mediated lipid accumulation in lung cancer · Ai N. H. Phan · 2017 · 26 citations · Cited by this paper
  34. Mechanistic Insights into Side Effects of Troglitazone and Rosiglitazone Using a Novel Inverse Molecular Docking Protocol · Katarina Kores · 2021 · 26 citations · Cited by this paper
  35. Advances in the targeted therapy of liposarcoma · Guan · 2015 · 25 citations · Cited by this paper
  36. Late-onset troglitazone-induced hepatic dysfunction. · David S.H. Bell · 2000 · 21 citations · Cited by this paper
  37. Peroxisome proliferator-activated receptor-γ inhibits pancreatic cancer cell invasion and metastasis via regulating MMP-2 expression through PTEN · Yue Li · 2015 · 18 citations · Cited by this paper
  38. Development and Validation of a Prognostic Model to Predict the Prognosis of Patients With Retroperitoneal Liposarcoma: A Large International Population-Based Cohort Study · Yiding Li · 2022 · 18 citations · Cited by this paper
  39. Genetic, Epigenetic and Transcriptome Alterations in Liposarcoma for Target Therapy Selection · Ekaterina A. Lesovaya · 2024 · 14 citations · Cited by this paper

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