Research map: Molecular interplay of insulin resistance and cancer: advances in monoclonal antibody therapeutics

Back to the article

Papers in this map

  1. PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer · Antonino Glaviano · 2023 · 2116 citations · Cited by this paper
  2. Validation of the important role and prognostic value of KIF14 in triple-negative breast cancer · 2025 · Related
  3. Understanding the mechanism of IL-1β secretion · Gloria López‐Castejón · 2011 · 1547 citations · Cited by this paper
  4. NCAPD2 promotes the progression of lung adenocarcinoma through an AKT/MDM2/E2F1 positive feedback loop · 2025 · Related
  5. Angiogenic signaling pathways and anti-angiogenic therapy for cancer · Zhenling Liu · 2023 · 1297 citations · Cited by this paper
  6. Parthenolide inhibits the progression of intrahepatic cholangiocarcinoma by promoting ferroptosis through inhibiting UBD · 2026 · Related
  7. Trends in insulin resistance: insights into mechanisms and therapeutic strategy · Mengwei Li · 2022 · 922 citations · Cited by this paper
  8. Assessing progesterone receptor modulation in glioblastoma: from in vitro and animal model to a human pilot protocol · 2025 · Related
  9. Metabolic programming and immune suppression in the tumor microenvironment · Emily Nicole Arner · 2023 · 678 citations · Cited by this paper
  10. Research progress on the compositional characteristics of the tumor immune microenvironment and immunopredictive models in esophageal squamous cell carcinoma · 2026 · Related
  11. Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy · Xi Lu · 2024 · 642 citations · Cited by this paper
  12. Obesity, chronic breast inflammation and carcinogenesis: Molecular pathways and clinical implications (Review) · 2025 · Related
  13. The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases · Hallie Blevins · 2022 · 582 citations · Cited by this paper
  14. The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity · 2026 · Related
  15. The crucial role and mechanism of insulin resistance in metabolic disease · Xuefei Zhao · 2023 · 569 citations · Cited by this paper
  16. Downregulation of the lncRNA PGM5P4-AS1 predicts poor prognosis and drives breast cancer progression through miR-3664-5p/KLF9 · 2025 · Related
  17. Hypoxia signaling in human health and diseases: implications and prospects for therapeutics · Zhen Luo · 2022 · 502 citations · Cited by this paper
  18. Mechanisms of resistance to antibody-drug conjugates in cancer therapy: molecular basis and therapeutic strategies · 2025 · Related
  19. The role of IL-6/JAK2/STAT3 signaling pathway in cancers · Bei Huang · 2022 · 490 citations · Cited by this paper
  20. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation · Jean‐François Tanti · 2009 · 420 citations · Cited by this paper
  21. Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches · Muhammad Tufail · 2025 · 347 citations · Cited by this paper
  22. Inhibitors of immune checkpoints—PD-1, PD-L1, CTLA-4—new opportunities for cancer patients and a new challenge for internists and general practitioners · Marek Z. Wojtukiewicz · 2021 · 338 citations · Cited by this paper
  23. Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments · Jiasheng Xu · 2025 · 314 citations · Cited by this paper
  24. Hyperinsulinemia in Obesity, Inflammation, and Cancer · Anni Zhang · 2021 · 307 citations · Cited by this paper
  25. Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy · Hui Hua · 2020 · 287 citations · Cited by this paper
  26. Nivolumab as Programmed Death-1 (PD-1) Inhibitor for Targeted Immunotherapy in Tumor · Liting Guo · 2017 · 283 citations · Cited by this paper
  27. The Role of Inflammation in Cancer: Mechanisms of Tumor Initiation, Progression, and Metastasis · Atsushi Nishida · 2025 · 259 citations · Cited by this paper
  28. Hyperinsulinaemia in cancer · Emily J. Gallagher · 2020 · 248 citations · Cited by this paper
  29. Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy · Esteban Cruz · 2019 · 225 citations · Cited by this paper
  30. IGF-1R as an anti-cancer target--trials and tribulations · Helen X. Chen · 2013 · 203 citations · Cited by this paper
  31. The insulin like growth factor and binding protein family: Novel therapeutic targets in obesity & diabetes · Natalie J Haywood · 2018 · 179 citations · Cited by this paper
  32. The Role of the Insulin/IGF System in Cancer: Lessons Learned from Clinical Trials and the Energy Balance-Cancer Link · Laura W. Bowers · 2015 · 176 citations · Cited by this paper
  33. Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group · Brenda J. Weigel · 2013 · 166 citations · Cited by this paper
  34. Interplay Between Insulin Resistance and Immune Dysregulation in Type 2 Diabetes Mellitus: Implications for Therapeutic Interventions · Afiat Berbudi · 2025 · 160 citations · Cited by this paper
  35. Therapeutic Targeting of the IGF Axis · Eliot L. Osher · 2019 · 158 citations · Cited by this paper
  36. Targeting the NLRP3 inflammasome for inflammatory disease therapy · Julia Elise Cabral · 2025 · 144 citations · Cited by this paper
  37. Extracellular matrix dynamics in tumor immunoregulation: from tumor microenvironment to immunotherapy · Qin Hu · 2025 · 130 citations · Cited by this paper
  38. MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity · Kamal U. Saikh · 2021 · 124 citations · Cited by this paper
  39. Insights into IL-6/JAK/STAT3 signaling in the tumor microenvironment: Implications for cancer therapy · Win Lwin Thuya · 2025 · 120 citations · Cited by this paper

Source: OpenAlex (CC0)