Research map: Creatine Supplementation Reduces Guanidinoacetate via Downregulation of AGAT in a Mouse Model of GAMT Deficiency

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  1. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes · Jo Vandesompele · 2002 · 20367 citations · Cited by this paper
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  5. Creatine Deficiency in the Brain: A New, Treatable Inborn Error of Metabolism · Sylvia Stöckler · 1994 · 417 citations · Cited by this paper
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  9. Creatine deficiency syndromes · Andreas Schulze · 2003 · 193 citations · Cited by this paper
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  11. Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency · Andreas C. Schmidt · 2004 · 176 citations · Cited by this paper
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  13. Improving Treatment of Guanidinoacetate Methyltransferase Deficiency: Reduction of Guanidinoacetic Acid in Body Fluids by Arginine Restriction and Ornithine Supplementation · Andreas Schulze · 2001 · 162 citations · Cited by this paper
  14. Maternal and Fetal Outcomes in Imiglucerase‐Treated Patients With Gaucher Disease: Real‐World Evidence From the International Collaborative Gaucher Group ( ICGG ) Gaucher Registry Pregnancy Sub‐Registry · 2026 · Related
  15. Guanidinoacetate methyltransferase (GAMT) deficiency: Outcomes in 48 individuals and recommendations for diagnosis, treatment and monitoring · Sylvia Stöckler‐Ipsiroglu · 2013 · 144 citations · Cited by this paper
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  17. Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals · Bart Marescau · 1992 · 137 citations · Cited by this paper
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  19. Metabolic Control of Creatine Biosynthesis · James B. Walker · 1960 · 124 citations · Cited by this paper
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  21. Repression of rat kidney L-arginine:glycine amidinotransferase synthesis by creatine at a pretranslational level. · Denise M. McGuire · 1984 · 103 citations · Cited by this paper
  22. Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine · Ernest A. Boehm · 2003 · 66 citations · Cited by this paper
  23. MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)‐deficient mice: Validation of an animal model to study creatine deficiency · W. Klaas Jan Renema · 2003 · 58 citations · Cited by this paper
  24. In vivo cardiac 1H‐MRS in the mouse · Jürgen E. Schneider · 2004 · 58 citations · Cited by this paper
  25. Repression of arginine-glycine transamidinase activity by dietary creatine · James B. Walker · 1959 · 53 citations · Cited by this paper
  26. Brain creatine depletion in vegetarians? A cross-sectional 1 H-magnetic resonance spectroscopy ( 1 H-MRS) study · Marina Yázigi Solis · 2013 · 47 citations · Cited by this paper
  27. Biochemical and behavioural phenotyping of a mouse model for GAMT deficiency · An Torremans · 2005 · 39 citations · Cited by this paper
  28. Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy · Hermien E. Kan · 2007 · 28 citations · Cited by this paper
  29. Creatine uptake in mouse hearts with genetically altered creatine levels · Michiel ten Hove · 2008 · 25 citations · Cited by this paper
  30. Systemic availability of guanidinoacetate affects GABAA receptor function and seizure threshold in GAMT deficient mice · Andreas Schulze · 2016 · 23 citations · Cited by this paper
  31. Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice · Dunja Aksentijević · 2020 · 18 citations · Cited by this paper
  32. Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes · Ryuta Jomura · 2021 · 18 citations · Cited by this paper
  33. Quantitative Studies on Enzyme Repression in the Developing Chick Embryo and Newly Hatched Chick. · James B. Walker · 1963 · 9 citations · Cited by this paper
  34. Influence of homoarginine on creatine accumulation and biosynthesis in the mouse · Craig A. Lygate · 2022 · 7 citations · Cited by this paper
  35. Magnetic resonance imaging reveals specific anatomical changes in the brain of Agat‐ and Gamt‐mice attributed to creatine depletion and guanidinoacetate alteration · Ankit Kumar Sinha · 2020 · 5 citations · Cited by this paper
  36. [18F]FDG-PET and [18F]MPPF-PET are brain biomarkers for the creatine transporter Slc6a8 loss of function mutation · Isabel L Day · 2025 · 3 citations · Cited by this paper
  37. Validation and Optimization of a Stable Isotope-Labeled Substrate Assay for Measuring AGAT Activity · Alex Lee · 2024 · 1 citation · Cited by this paper

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