Research map: Protein-Level and Proteomics-Supported Signatures of Human CD4+ Regulatory T Cells: Evidence, Tissue Context, and Translational Readiness in Aging and Age-Associated Disease

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  1. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells · Weihong Liu · 2006 · 2630 citations · Cited by this paper
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  11. CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors · Haiping Wang · 2020 · 682 citations · Cited by this paper
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  15. Regulatory T cells promote myelin regeneration in the central nervous system · Yvonne Dombrowski · 2017 · 575 citations · Cited by this paper
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  17. Revisiting the PD-1 pathway · Nikolaos Patsoukis · 2020 · 552 citations · Cited by this paper
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  19. Two Functional Subsets of FOXP3+ Regulatory T Cells in Human Thymus and Periphery · Tomoki� Ito · 2008 · 540 citations · Cited by this paper
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  21. Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells · Murat Tekgüç · 2021 · 489 citations · Cited by this paper
  22. Principles of regulatory T cell function · Stanislav Dikiy · 2023 · 445 citations · Cited by this paper
  23. JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens · Qian Hu · 2023 · 341 citations · Cited by this paper
  24. Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF · Michael Delacher · 2020 · 284 citations · Cited by this paper
  25. The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases · Siwen Zhang · 2021 · 257 citations · Cited by this paper
  26. The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy · Jiajing Cai · 2019 · 241 citations · Cited by this paper
  27. The Complex Role of Regulatory T Cells in Immunity and Aging · Lourdes Rocamora‐Reverte · 2021 · 232 citations · Cited by this paper
  28. The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes · Shen Dong · 2021 · 229 citations · Cited by this paper
  29. Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance · Jeremy A. Sullivan · 2020 · 165 citations · Cited by this paper
  30. Foxp3 Post-translational Modifications and Treg Suppressive Activity · Guoping Deng · 2019 · 163 citations · Cited by this paper
  31. Mechanisms underlying immunosuppression by regulatory cells · Oliver Goldmann · 2024 · 151 citations · Cited by this paper
  32. Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity · Eloy Cuadrado · 2018 · 144 citations · Cited by this paper
  33. The Characterization of Regulatory T-Cell Profiles in Alzheimer’s Disease and Multiple Sclerosis · Fausta Ciccocioppo · 2019 · 139 citations · Cited by this paper
  34. Upregulation of PD-L1 in Senescence and Aging · Angelique Onorati · 2022 · 132 citations · Cited by this paper
  35. CD25 : A potential tumor therapeutic target · Yujia Peng · 2022 · 124 citations · Cited by this paper
  36. Human FOXP3 and tumour microenvironment · Jia Wang · 2022 · 120 citations · Cited by this paper
  37. Current Understanding of Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) Signaling in T-Cell Biology and Disease Therapy · Gil‐Ran Kim · 2022 · 117 citations · Cited by this paper
  38. CCR4 as a Therapeutic Target for Cancer Immunotherapy · Osamu Yoshie · 2021 · 112 citations · Cited by this paper
  39. BATF epigenetically and transcriptionally controls the activation program of regulatory T cells in human tumors · Kota Itahashi · 2022 · 111 citations · Cited by this paper

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