Research map: The interplay between oncolytic viruses, Toll-like receptor signaling, and chemotherapy in overcoming tumor immune tolerance

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Papers in this map

  1. Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer · Kai Li · 2021 · 1004 citations · Cited by this paper
  2. Integrated Multi-Omics Analyses Identify Core Determinants Governing Newcastle Disease Virus Oncolytic Therapy Efficacy Under Tumor Heterogeneity · Shufeng Feng · 2026 · Cites this paper
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  5. Functional analyses of male-specific early-phosphorylated proteins reveal an intrinsically disordered protein required for microgamete release in Plasmodium berghei · 2026 · Related
  6. Toll-Like Receptors in Antiviral Innate Immunity · Sandra N. Lester · 2013 · 738 citations · Cited by this paper
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  8. Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment · Chunmei Fu · 2018 · 628 citations · Cited by this paper
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  10. TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections · Seoyun Yum · 2021 · 582 citations · Cited by this paper
  11. Cooperation of transposable elements to endow global networks of initiators of hybrid assembly pathways of endogenous multiprotein complexes · 2026 · Related
  12. Type I Interferon in Chronic Virus Infection and Cancer · Laura M. Snell · 2017 · 535 citations · Cited by this paper
  13. Advancements on the synergistic application of oncolytic viruses and molecularly targeted therapies for the treatment of solid tumors (Review) · 2025 · Related
  14. Regulatory T Cells in the Tumor Microenvironment and Cancer Progression: Role and Therapeutic Targeting · Belal Chaudhary · 2016 · 518 citations · Cited by this paper
  15. Oncolytic virus and immunogenic cell death in cancer therapy · 2025 · Related
  16. The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy · Qiyao Yang · 2020 · 491 citations · Cited by this paper
  17. Tumor Microenvironment Onmyoji: Cytokines with Dual Protumor and Antitumor Roles · 2026 · Related
  18. Role of tumor microenvironment in cancer progression and therapeutic strategy · Qingjing Wang · 2023 · 457 citations · Cited by this paper
  19. Synergistic interactions and optimal sequencing of chemotherapy and immunotherapy in cancer treatment · 2026 · Related
  20. Development of TLR9 agonists for cancer therapy · Arthur Μ. Krieg · 2007 · 437 citations · Cited by this paper
  21. The “cytokine storm” in infection and sepsis: win the battle but lose the war · 2026 · Related
  22. Regulation of PD-L1 Expression by NF-κB in Cancer · Fabrizio Antonangeli · 2020 · 398 citations · Cited by this paper
  23. Immunologic tumor microenvironment modulators for turning cold tumors hot · Gholamreza Reza Khosravi · 2024 · 362 citations · Cited by this paper
  24. Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches · Muhammad Tufail · 2025 · 342 citations · Cited by this paper
  25. Talimogene Laherparepvec (T-VEC): An Intralesional Cancer Immunotherapy for Advanced Melanoma · Pier Francesco Ferrucci · 2021 · 325 citations · Cited by this paper
  26. Pattern recognition receptors: function, regulation and therapeutic potential · Ruochan Chen · 2025 · 285 citations · Cited by this paper
  27. IL-10/TGF-β–Modified Macrophages Induce Regulatory T Cells and Protect against Adriamycin Nephrosis · Qi Cao · 2010 · 279 citations · Cited by this paper
  28. Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives · Xiaoli Shi · 2024 · 252 citations · Cited by this paper
  29. Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses · Yujuan Chen · 2021 · 236 citations · Cited by this paper
  30. Exploiting innate immunity for cancer immunotherapy · Ming Yi · 2023 · 236 citations · Cited by this paper
  31. Overview of Infections in the Immunocompromised Host · Lesia K. Dropulic · 2016 · 234 citations · Cited by this paper
  32. Small-Molecule Modulators of Toll-like Receptors · Yibo Wang · 2020 · 226 citations · Cited by this paper
  33. Gemcitabine reduces MDSCs, tregs and TGFβ-1 while restoring the teff/treg ratio in patients with pancreatic cancer · Emma Eriksson · 2016 · 223 citations · Cited by this paper
  34. Extracellular Matrices and Cancer-Associated Fibroblasts: Targets for Cancer Diagnosis and Therapy? · Ismahane Belhabib · 2021 · 186 citations · Cited by this paper
  35. Strategies to Increase Drug Penetration in Solid Tumors · Il-Kyu Choi · 2013 · 179 citations · Cited by this paper
  36. Chemo-Immunotherapy: A New Trend in Cancer Treatment · Christian Sordo‐Bahamonde · 2023 · 178 citations · Cited by this paper
  37. Oncolytic Viruses: Newest Frontier for Cancer Immunotherapy · Masmudur M. Rahman · 2021 · 165 citations · Cited by this paper
  38. Role of chemokines in the crosstalk between tumor and tumor-associated macrophages · Rui Qin · 2022 · 160 citations · Cited by this paper
  39. Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells · Yue Guo · 2020 · 159 citations · Cited by this paper

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