Research map: The Emerging Role of UCHL1 in Neurological and Musculoskeletal Diseases

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Papers in this map

  1. The Ubiquitin Code · David Komander · 2012 · 3777 citations · Cited by this paper
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  11. The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy · Yong Tae Kwon · 2017 · 845 citations · Cited by this paper
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  13. Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study · Jeffrey J. Bazarian · 2018 · 620 citations · Cited by this paper
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  15. Proteomic identification of oxidatively modified proteins in alzheimer’s disease brain. part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1 · Alessandra Castegna · 2002 · 584 citations · Cited by this paper
  16. Age‐related differences in mRNA vaccine immunogenicity and adjuvancy · 2026 · Related
  17. Oxidative Modifications and Down-regulation of Ubiquitin Carboxyl-terminal Hydrolase L1 Associated with Idiopathic Parkinson's and Alzheimer's Diseases · Joungil Choi · 2004 · 573 citations · Cited by this paper
  18. Exploring SIK2 ‐ CXCL5 interactions in neutrophils: A novel mechanism for modulating IL ‐23 and psoriasis progression · 2026 · Related
  19. Deubiquitylases From Genes to Organism · Michael J. Clague · 2013 · 433 citations · Cited by this paper
  20. Functional immune profiling reveals CD4 + T cell dysregulation in coeliac disease · 2026 · Related
  21. Ubiquitin Hydrolase Uch-L1 Rescues β-Amyloid-Induced Decreases in Synaptic Function and Contextual Memory · Bing Gong · 2006 · 425 citations · Cited by this paper
  22. The ubiquitin-proteasome system in neurodegenerative diseases: precipitating factor, yet part of the solution · Nico P. Dantuma · 2014 · 344 citations · Cited by this paper
  23. The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death · Ido Livneh · 2016 · 340 citations · Cited by this paper
  24. The functions of UCH-L1 and its relation to neurodegenerative diseases · Rieko Setsuie · 2007 · 288 citations · Cited by this paper
  25. UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein · Ian N.M. Day · 2009 · 267 citations · Cited by this paper
  26. UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α · Yökö Gotö · 2015 · 239 citations · Cited by this paper
  27. Aberrant Interaction between Parkinson Disease-associated Mutant UCH-L1 and the Lysosomal Receptor for Chaperone-mediated Autophagy · Tomohiro Kabuta · 2008 · 227 citations · Cited by this paper
  28. Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications · Ying Fang · 2017 · 194 citations · Cited by this paper
  29. The IL-23/IL-17 axis in psoriatic arthritis · Érika Suzuki · 2014 · 185 citations · Cited by this paper
  30. The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma · Lili Li · 2010 · 172 citations · Cited by this paper
  31. Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease · Zhihua Liu · 2009 · 143 citations · Cited by this paper
  32. Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation · Ramesh Ummanni · 2011 · 142 citations · Cited by this paper
  33. Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo · Mingming Zhang · 2014 · 139 citations · Cited by this paper
  34. Expression analysis of the long non-coding RNA antisense to Uchl1 (AS Uchl1) during dopaminergic cells' differentiation in vitro and in neurochemical models of Parkinson's disease · Claudia Carrieri · 2015 · 126 citations · Cited by this paper
  35. Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury · Zhiping Mi · 2023 · 107 citations · Cited by this paper
  36. The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor · Hai-Lian Bi · 2020 · 105 citations · Cited by this paper
  37. Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective · François Le Guerroué · 2020 · 101 citations · Cited by this paper
  38. Silencing of the UCHL1 gene in human colorectal and ovarian cancers · Eriko Okochi‐Takada · 2006 · 99 citations · Cited by this paper
  39. Aberrant molecular properties shared by familial Parkinson’s disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1 · Tomohiro Kabuta · 2008 · 94 citations · Cited by this paper

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