Research map: Per- and polyfluoroalkyl substances and type 2 diabetes risk: Evidence from metabolomics and triglyceride-glucose index-related pathways

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Papers in this map

  1. Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling · Haitao Wen · 2011 · 1804 citations · Cited by this paper
  2. Short-term and lagged effects of ambient air pollution on emergency visits for cardiovascular diseases modified by meteorological factors · 2026 · Related
  3. Elevated Levels of Ultrashort- and Short-Chain Perfluoroalkyl Acids in US Homes and People · Guomao Zheng · 2023 · 236 citations · Cited by this paper
  4. Individual and joint association between per- and polyfluoroalkyl substances and skeletal muscle among 6-9 years old children in China · 2026 · Related
  5. Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis · Sandeep Samethadka Nayak · 2024 · 213 citations · Cited by this paper
  6. Within day temperature variation and pediatric asthma exacerbation in Philadelphia, PA · 2026 · Related
  7. Plasma Concentrations of Perfluoroalkyl Substances and Risk of Type 2 Diabetes: A Prospective Investigation among U.S. Women · Qi Sun · 2018 · 177 citations · Cited by this paper
  8. Association of phthalate exposure during early pregnancy with fetal growth and the effect modification by gestational stress · 2026 · Related
  9. Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach · Che-Jung Chang · 2021 · 167 citations · Cited by this paper
  10. Book of Abstracts: OHSI/ISES Europe joint 2026 Workshop; Dublin, Ireland, June 10th – 11th, 2026 · 2026 · Related
  11. Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis · Tanya L. Alderete · 2019 · 164 citations · Cited by this paper
  12. Exposure to ambient PM2.5 constituents and semen quality in a retrospective cohort study: Windows of susceptibility and modification by greenness · 2026 · Related
  13. Insulin resistance in type 2 diabetes mellitus · Domenico Accili · 2025 · 151 citations · Cited by this paper
  14. Advancing PFAS biomonitoring with a validated high-throughput suspect screening workflow in a longitudinal birth cohort · 2026 · Related
  15. Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly · Lars Lind · 2013 · 129 citations · Cited by this paper
  16. Comparison of domestic and mixed wastewater reveals limited impact of hospital effluent discharge on antibiotic resistance · 2026 · Related
  17. High plasma glutamate and low glutamine-to-glutamate ratio are associated with type 2 diabetes: Case-cohort study within the PREDIMED trial · Xiaoran Liu · 2019 · 121 citations · Cited by this paper
  18. Sex-specific associations between long-term exposure to ambient air pollution and the cardiac conduction system - a longitudinal analysis of the KORA cohort · 2026 · Related
  19. Per- and polyfluoroalkyl substances as persistent pollutants with metabolic and endocrine-disrupting impacts · Lucas Gaillard · 2024 · 117 citations · Cited by this paper
  20. Association between air temperature and COVID-19 emergency department visits in Ontario, Canada: A population-based case-crossover study · 2026 · Related
  21. PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies · Sandra India Aldana · 2023 · 112 citations · Cited by this paper
  22. The transplacental transfer efficiency of per- and polyfluoroalkyl substances (PFAS): a first meta-analysis · Mareike Appel · 2021 · 104 citations · Cited by this paper
  23. Diabetes in China: epidemiology, pathophysiology and multi-omics · Weiping Jia · 2025 · 99 citations · Cited by this paper
  24. Association between per- and polyfluoroalkyl substances exposure and risk of diabetes: a systematic review and meta-analysis · Siyu Gui · 2022 · 76 citations · Cited by this paper
  25. Exposure to novel and legacy per- and polyfluoroalkyl substances (PFASs) and associations with type 2 diabetes: A case-control study in East China · Xu Han · 2021 · 74 citations · Cited by this paper
  26. Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells · Sulaiman K. Marafie · 2019 · 55 citations · Cited by this paper
  27. Triglyceride–glucose index as predictor for future type 2 diabetes mellitus in a Chinese population in southwest China: a 15-year prospective study · Ziqiong Wang · 2021 · 55 citations · Cited by this paper
  28. Associations between both legacy and alternative per- and polyfluoroalkyl substances and glucose-homeostasis: The Isomers of C8 health project in China · Yun-Ting Zhang · 2021 · 55 citations · Cited by this paper
  29. Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity · Risheng Ye · 2018 · 47 citations · Cited by this paper
  30. PFAS biodegradation by Labrys portucalensis F11: Evidence of chain shortening and identification of metabolites of PFOS, 6:2 FTS, and 5:3 FTCA · Mindula K. Wijayahena · 2025 · 43 citations · Cited by this paper
  31. The role of TyG index in predicting the incidence of diabetes in Chinese elderly men: a 20-year retrospective study · Lingjun Rong · 2023 · 39 citations · Cited by this paper
  32. Role of Triglyceride-Glucose Index in Type 2 Diabetes Mellitus and Its Complications · Ying Pan · 2024 · 34 citations · Cited by this paper
  33. L-Glutamine and Whole Protein Restore First-Phase Insulin Response and Increase Glucagon-Like Peptide-1 in Type 2 Diabetes Patients · Dorit Samocha‐Bonet · 2015 · 24 citations · Cited by this paper
  34. In vitro screening of understudied PFAS with a focus on lipid metabolism disruption · Lackson Kashobwe · 2024 · 24 citations · Cited by this paper
  35. Glutamine deprivation induces metabolic adaptations associated with beta cell dysfunction and exacerbate lipotoxicity · Rodrigo Carlessi · 2019 · 23 citations · Cited by this paper
  36. Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance · Zengqi Zhao · 2024 · 22 citations · Cited by this paper
  37. Distribution, partitioning behaviors, and source identification of legacy and emerging per- and polyfluorinated alkyl substances in the Pearl River Estuary, South China · Bin Tang · 2025 · 22 citations · Cited by this paper
  38. Relationship between per-fluoroalkyl and polyfluoroalkyl substance exposure and insulin resistance in nondiabetic adults: Evidence from NHANES 2003–2018 · Peng Jia · 2024 · 16 citations · Cited by this paper
  39. Molecular Aspects of Lifestyle and Environmental Effects in Patients With Diabetes · Matthew Gregory Nayor · 2021 · 13 citations · Cited by this paper

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