Research map: ACK family tyrosine kinases as potential therapeutic targets for cancer

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  1. The Protein Kinase Complement of the Human Genome · Gerard Manning · 2002 · 8261 citations · Cited by this paper
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  13. PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeutics · Kiran N. Mahajan · 2012 · 241 citations · Cited by this paper
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  15. Activated Tyrosine Kinase Ack1 Promotes Prostate Tumorigenesis: Role of Ack1 in Polyubiquitination of Tumor Suppressor Wwox · Nupam P. Mahajan · 2005 · 232 citations · Cited by this paper
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  17. Small-Molecule Inhibitors of the Receptor Tyrosine Kinases: Promising Tools for Targeted Cancer Therapies · Mohammad Hojjat‐Farsangi · 2014 · 203 citations · Cited by this paper
  18. 5-FU in combination with PARP inhibitor ABT-888 deregulates MGMT-dependent mismatch repair (MMR) pathway in MMR-proficient colorectal cancer stem cells by modulating MGMT/PARP1/MSH6 complex · 2026 · Related
  19. Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation · Kiran N. Mahajan · 2010 · 182 citations · Cited by this paper
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  21. ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers · Kiran N. Mahajan · 2014 · 155 citations · Cited by this paper
  22. ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer · Kiran N. Mahajan · 2017 · 140 citations · Cited by this paper
  23. STAT3 and STAT5 Activation in Solid Cancers · Sebastian Igelmann · 2019 · 110 citations · Cited by this paper
  24. Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer · Kiran N. Mahajan · 2012 · 99 citations · Cited by this paper
  25. Intratumoral heterogeneity and drug resistance in cancer · Yue-Chun Fu · 2025 · 98 citations · Cited by this paper
  26. ACK1 tyrosine kinase: Targeted inhibition to block cancer cell proliferation · Kiran N. Mahajan · 2013 · 81 citations · Cited by this paper
  27. Biochemical Properties of the Cdc42-associated Tyrosine Kinase ACK1 · Noriko N. Yokoyama · 2003 · 80 citations · Cited by this paper
  28. KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic Strategy, and Potential Treatment Exploration · Yunkai Yang · 2023 · 78 citations · Cited by this paper
  29. Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1 · Julie C. Lougheed · 2004 · 66 citations · Cited by this paper
  30. Regulation of Ack-Family Nonreceptor Tyrosine Kinases · Victoria Prieto-Echagüe · 2011 · 50 citations · Cited by this paper
  31. Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors · Sarasija Hoare · 2008 · 50 citations · Cited by this paper
  32. Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR · Erin F. DiMauro · 2007 · 50 citations · Cited by this paper
  33. Dasatinib Inhibits the Growth of Molecularly Heterogeneous Myeloid Leukemias · Bella Samia Guerrouahen · 2010 · 48 citations · Cited by this paper
  34. ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling · Binhui Xie · 2015 · 36 citations · Cited by this paper
  35. Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer · Jinhong Zhu · 2021 · 34 citations · Cited by this paper
  36. High-throughput RNAi Screening Identifies a Role for TNK1 in Growth and Survival of Pancreatic Cancer Cells · Meredith C. Henderson · 2011 · 33 citations · Cited by this paper
  37. Inhibition of ACK1 delays and overcomes acquired resistance of EGFR mutant NSCLC cells to the third generation EGFR inhibitor, osimertinib · Jiajia Gu · 2020 · 33 citations · Cited by this paper
  38. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth · Tsz‐Yin Chan · 2021 · 33 citations · Cited by this paper
  39. Activated cdc42-associated kinase is up-regulated in non-small-cell lung cancer and necessary for FGFR-mediated AKT activation · Fengqing Hu · 2015 · 32 citations · Cited by this paper

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