Research map: Targeting Picornavirus Nonstructural 2C Protein: Structure, Function, and Antiviral Discovery

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Papers in this map

  1. Structure of a human common cold virus and functional relationship to other picornaviruses · Michael George Rossmann · 1985 · 1434 citations · Cited by this paper
  2. Recent Advances in Anti-Infective Drug Discovery from China · 2026 · Related
  3. Three-Dimensional Structure of Poliovirus at 2.9 Å Resolution · James M. Hogle · 1985 · 1267 citations · Cited by this paper
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  5. Modification of intracellular membrane structures for virus replication · Sven Miller · 2008 · 744 citations · Cited by this paper
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  7. ICTV Virus Taxonomy Profile: Picornaviridae · Roland Zell · 2017 · 676 citations · Cited by this paper
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  9. GENETICS OF POLIOVIRUS · Eckard Wimmer · 1993 · 549 citations · Cited by this paper
  10. Minimum Inoculum of Resistance Assay for Evaluating Antitoxoplasmosis Compounds That Target Phenylalanine tRNA Synthetase · 2026 · Related
  11. Mechanism of DNA translocation in a replicative hexameric helicase · Eric J. Enemark · 2006 · 543 citations · Cited by this paper
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  13. A protein covalently linked to poliovirus genome RNA. · Y F Lee · 1977 · 433 citations · Cited by this paper
  14. When Second Messenger Signaling Meets Resistance: (p)ppGpp, C-di-GMP and C-di-AMP as Masters of Antibiotic Stress Adaptation · 2026 · Related
  15. PROTEOLYTIC PROCESSING OF PICORNAVIRAL POLYPROTEIN · A C Palmenberg · 1990 · 361 citations · Cited by this paper
  16. Metabolic Screening of Gut Microbiota by Fourier-Transform Infrared Spectroscopy · 2026 · Related
  17. Polypeptide cleavages in the formation of poliovirus proteins. · Michael F. Jacobson · 1968 · 351 citations · Cited by this paper
  18. Platanosides, a Promising Class of Plant-Derived Antibiotics, Are Effective against a Suite of Clinically Derived MDR and Drug-Sensitive Staph and Strep spp. · 2026 · Related
  19. Membrane Rearrangement and Vesicle Induction by Recombinant Poliovirus 2C and 2BC in Human Cells · Michael W. Cho · 1994 · 314 citations · Cited by this paper
  20. Plasminogen Recruitment by Staphylococcus aureus SdrC Reveals a Tractable Antivirulence Target · 2026 · Related
  21. Selective inhibitors of picornavirus replication · Armando M. De Palma · 2008 · 259 citations · Cited by this paper
  22. Picornavirus Morphogenesis · Ping Jiang · 2014 · 238 citations · Cited by this paper
  23. TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination · Jun Yan · 2014 · 225 citations · Cited by this paper
  24. Crystal Structure of Human Enterovirus 71 · Pavel Plevka · 2012 · 222 citations · Cited by this paper
  25. Viral and host proteins involved in picornavirus life cycle · Jing‐Yi Lin · 2009 · 203 citations · Cited by this paper
  26. Poliovirus protein 2C has ATPase and GTPase activities. · Pedro L. Rodrı́guez · 1993 · 197 citations · Cited by this paper
  27. Bridging IRES elements in mRNAs to the eukaryotic translation apparatus · Kerry D. Fitzgerald · 2009 · 195 citations · Cited by this paper
  28. ACBD3‐mediated recruitment of PI4KB to picornavirus RNA replication sites · Jun D. Sasaki · 2011 · 193 citations · Cited by this paper
  29. Characterization of the Nucleoside Triphosphatase Activity of Poliovirus Protein 2C Reveals a Mechanism by Which Guanidine Inhibits Poliovirus Replication · Thomas Daniel Pfister · 1999 · 186 citations · Cited by this paper
  30. Structure and inhibition of EV-D68, a virus that causes respiratory illness in children · Yue Liu · 2015 · 184 citations · Cited by this paper
  31. Guanidine-selected mutants of poliovirus: mapping of point mutations to polypeptide 2C · Steve E. Pincus · 1986 · 177 citations · Cited by this paper
  32. hCAS/CSE1L Associates with Chromatin and Regulates Expression of Select p53 Target Genes · Tomoaki Tanaka · 2007 · 176 citations · Cited by this paper
  33. Synchronous replication of poliovirus RNA: initiation of negative-strand RNA synthesis requires the guanidine-inhibited activity of protein 2C · David J. Barton · 1997 · 167 citations · Cited by this paper
  34. Viral Generated Inter-Organelle Contacts Redirect Lipid Flux for Genome Replication · Orly Laufman · 2019 · 167 citations · Cited by this paper
  35. Reticulon 3 Binds the 2C Protein of Enterovirus 71 and Is Required for Viral Replication · Wenfang Tang · 2006 · 166 citations · Cited by this paper
  36. Poliovirus 2C protein determinants of membrane binding and rearrangements in mammalian cells · Natalya L. Teterina · 1997 · 162 citations · Cited by this paper
  37. Direct Interaction between Two Viral Proteins, the Nonstructural Protein 2CATPase and the Capsid Protein VP3, Is Required for Enterovirus Morphogenesis · Ying Liu · 2010 · 150 citations · Cited by this paper
  38. The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus · B.A. Heinz · 1995 · 142 citations · Cited by this paper
  39. Effects of Foot-and-Mouth Disease Virus Nonstructural Proteins on the Structure and Function of the Early Secretory Pathway: 2BC but Not 3A Blocks Endoplasmic Reticulum-to-Golgi Transport · Katy Moffat · 2005 · 141 citations · Cited by this paper

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