Research map: Sustained-release local anesthetics: advances in drug delivery systems for prolonged postoperative analgesia

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Papers in this map

  1. Designing hydrogels for controlled drug delivery · Jianyu Li · 2016 · 4857 citations · Cited by this paper
  2. Utility of the tympanic membrane temperature probe for continuous core temperature monitoring during general anesthesia: in vitro laboratory validation and prospective observational study · 2025 · Related
  3. Liposomal drug delivery systems: From concept to clinical applications · Theresa M. Allen · 2012 · 4823 citations · Cited by this paper
  4. Intraoperative lactate level and lactate clearance is associated with long-term mortality in liver transplant recipients · 2025 · Related
  5. Hydrophilic Gels for Biological Use · O. Wichterle · 1960 · 2991 citations · Cited by this paper
  6. From labor to surgery: expanding the role of programmed intermittent epidural bolus beyond obstetric · 2026 · Related
  7. New Persistent Opioid Use After Minor and Major Surgical Procedures in US Adults · Chad M. Brummett · 2017 · 2034 citations · Cited by this paper
  8. Utility of real-time ultrasound-guided spinal anesthesia in severe ankylosing spondylitis - A case report - · 2026 · Related
  9. Controlled Drug Delivery Systems: Current Status and Future Directions · Shivakalyani Adepu · 2021 · 1735 citations · Cited by this paper
  10. A prospective randomized study to evaluate the effect of epidural volume extension with normal saline in combined spinal epidural anesthesia for lower limb surgeries using intrathecal hyperbaric levobupivacaine · 2026 · Related
  11. Poorly controlled postoperative pain: prevalence, consequences, and prevention · Tong Joo Gan · 2017 · 1515 citations · Cited by this paper
  12. Intercostal nerve cryoanalgesia in lung transplantation: a retrospective single-center study · 2026 · Related
  13. The origins and evolution of “controlled” drug delivery systems · Allan S. Hoffman · 2008 · 739 citations · Cited by this paper
  14. Prediction of postoperative desaturation and bradycardia in neonates undergoing laparoscopic inguinal hernia repair: a retrospective cohort study · 2026 · Related
  15. Hydrogels as Drug Delivery Systems: A Review of Current Characterization and Evaluation Techniques · Margaux Vigata · 2020 · 543 citations · Cited by this paper
  16. Suspected remimazolam formulation-associated peri-induction anaphylaxis: two cases highlighting diagnostic complexity - Two case reports - · 2026 · Related
  17. Hydrogels for Therapeutic Delivery: Current Developments and Future Directions · Sytze J. Buwalda · 2016 · 498 citations · Cited by this paper
  18. Cervical facet joint interventions for neck pain: an anatomically and clinically focused review · 2025 · Related
  19. Poloxamer: A versatile tri-block copolymer for biomedical applications · Payam Zarrintaj · 2020 · 406 citations · Cited by this paper
  20. Anesthesia for uterine transplantation · 2026 · Related
  21. Poloxamer Hydrogels for Biomedical Applications · Eleonora Russo · 2019 · 401 citations · Cited by this paper
  22. Hyaluronic Acid and Controlled Release: A Review · Ilker S. Bayer · 2020 · 354 citations · Cited by this paper
  23. Bupivacaine Extended-Release Liposome Injection for Prolonged Postsurgical Analgesia in Patients Undergoing Hemorrhoidectomy: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial · Stephen R. Gorfine · 2011 · 351 citations · Cited by this paper
  24. Improving Postoperative Pain Management · Paul F. White · 2009 · 334 citations · Cited by this paper
  25. Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery · Sonia Trombino · 2019 · 311 citations · Cited by this paper
  26. A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty · Kenneth W. Bramlett · 2012 · 292 citations · Cited by this paper
  27. A phase 3, randomized, placebo-controlled trial of DepoFoam® bupivacaine (extended-release bupivacaine local analgesic) in bunionectomy · Michael Golf · 2011 · 251 citations · Cited by this paper
  28. Advances in Hydrogel-Based Drug Delivery Systems · Boya Liu · 2024 · 223 citations · Cited by this paper
  29. Biocompatibility and biodegradation of different hyaluronan derivatives (Hyaff) implanted in rats · L. Benedetti · 1993 · 215 citations · Cited by this paper
  30. Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain · Brian M. Ilfeld · 2020 · 194 citations · Cited by this paper
  31. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid · Xinqiao Jia · 2004 · 193 citations · Cited by this paper
  32. Current Advances in Stimuli-Responsive Hydrogels as Smart Drug Delivery Carriers · Yulong Zhang · 2023 · 190 citations · Cited by this paper
  33. Perineural Liposomal Bupivacaine Is Not Superior to Nonliposomal Bupivacaine for Peripheral Nerve Block Analgesia · Nasir Hussain · 2020 · 186 citations · Cited by this paper
  34. Local Infiltration Analgesia With Liposomal Bupivacaine Improves Pain Scores and Reduces Opioid Use After Total Knee Arthroplasty: Results of a Randomized Controlled Trial · Michael A. Mont · 2017 · 165 citations · Cited by this paper
  35. The Science of Local Anesthesia: Basic Research, Clinical Application, and Future Directions · Philipp B. Lirk · 2017 · 158 citations · Cited by this paper
  36. Drug delivery systems for prolonged duration local anesthesia · Claudia M. Santamaria · 2016 · 129 citations · Cited by this paper
  37. Preventive Analgesia to Reduce Wound Hyperalgesia and Persistent Postsurgical Pain · Timothy J. Brennan · 2005 · 119 citations · Cited by this paper
  38. Transversus Abdominis Plane Block With Liposomal Bupivacaine for Pain After Cesarean Delivery in a Multicenter, Randomized, Double-Blind, Controlled Trial · Srdjan S. Nedeljković · 2020 · 117 citations · Cited by this paper
  39. The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs · Brigitte M. Richard · 2012 · 112 citations · Cited by this paper

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