Research map: The role of transglutaminase family in central nervous system diseases: From molecular mechanisms to therapeutic targets

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  1. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice · Taichi Hara · 2006 · 3903 citations · Cited by this paper
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  17. Epidermal Transglutaminase (TGase 3) Is the Autoantigen of Dermatitis Herpetiformis · Miklós Sárdy · 2002 · 519 citations · Cited by this paper
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  19. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease · Bahareh Eftekharzadeh · 2018 · 480 citations · Cited by this paper
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  21. Autophagy in neurodegenerative diseases: pathogenesis and therapy · Fang Guo · 2017 · 459 citations · Cited by this paper
  22. Transglutaminase 2 Undergoes a Large Conformational Change upon Activation · Daniel M. Pinkas · 2007 · 455 citations · Cited by this paper
  23. Transglutaminase Regulation of Cell Function · Richard L. Eckert · 2014 · 437 citations · Cited by this paper
  24. Post-translational modifications of tubulin: pathways to functional diversity of microtubules · Yuyu Song · 2014 · 397 citations · Cited by this paper
  25. Mutant Huntingtin Disrupts the Nuclear Pore Complex · Jonathan C. Grima · 2017 · 383 citations · Cited by this paper
  26. Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine · Marcela Viviana Karpuj · 2002 · 381 citations · Cited by this paper
  27. Transglutaminases and Disease: Lessons From Genetically Engineered Mouse Models and Inherited Disorders · Siiri E. Iismaa · 2009 · 335 citations · Cited by this paper
  28. Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy · Selcuk A. Tanik · 2013 · 330 citations · Cited by this paper
  29. Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation · Plamena R. Angelova · 2020 · 317 citations · Cited by this paper
  30. Single-cell multiregion dissection of Alzheimer’s disease · Hansruedi Mathys · 2024 · 316 citations · Cited by this paper
  31. Therapeutic Effects of Cystamine in a Murine Model of Huntington's Disease · Alpaslan Dedeoglu · 2002 · 315 citations · Cited by this paper
  32. TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing · Junling Wang · 2010 · 280 citations · Cited by this paper
  33. Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport · Fátima Gasset-Rosa · 2017 · 257 citations · Cited by this paper
  34. Transglutaminase 2: A molecular Swiss army knife · Soner Gundemir · 2011 · 250 citations · Cited by this paper
  35. Formation of α-synuclein Lewy neurite–like aggregates in axons impedes the transport of distinct endosomes · Laura A. Volpicelli‐Daley · 2014 · 242 citations · Cited by this paper
  36. A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease · Detlef Schuppan · 2021 · 239 citations · Cited by this paper
  37. ‘Tissue’ transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease · Pier G. Mastroberardino · 2002 · 227 citations · Cited by this paper
  38. Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington’s disease brain nuclei · Marcela Viviana Karpuj · 1999 · 226 citations · Cited by this paper
  39. Differential Expression of Multiple Transglutaminases in Human Brain · Soo‐Youl Kim · 1999 · 224 citations · Cited by this paper

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