Research map: Adeno-Associated Virus-Mediated Central Nervous System Gene Transfer to Suppress Alzheimer’s Disease High-Risk APOE4 Variant and Replace with Protective APOE2

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  1. Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families · Elizabeth H. Corder · 1993 · 9586 citations · Cited by this paper
  2. Retroviral Transduction of Human CD4 + T Cells with Membrane-Attached IL-10 Generates Type 1-Like Regulatory T Cells · 2026 · Related
  3. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium · Lindsay A. Farrer · 1997 · 4827 citations · Cited by this paper
  4. Optimization of Alpha-1 Antitrypsin Expression from Adeno-Associated Virus Vectors · 2026 · Related
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  8. High Prevalence of Preexisting Neutralizing Antibodies Against Adeno-Associated Virus Capsids in Mongolian People with Hemophilia · 2026 · Related
  9. ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions · Philip B. Verghese · 2013 · 569 citations · Cited by this paper
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  13. APOE4 homozygosity represents a distinct genetic form of Alzheimer’s disease · Juan Fortea · 2024 · 363 citations · Cited by this paper
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  15. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias · Yuka A. Martens · 2022 · 349 citations · Cited by this paper
  16. Capsid Engineering of Adeno-Associated Viruses for Targeted Gene Therapy in Kidney Diseases · 2026 · Related
  17. The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study · Sven J. van der Lee · 2018 · 321 citations · Cited by this paper
  18. Ethical and Regulatory Considerations for Developing Gene Therapies Involving Genome Editing · 2026 · Related
  19. APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry · Michaël E. Belloy · 2023 · 316 citations · Cited by this paper
  20. APOE mediated neuroinflammation and neurodegeneration in Alzheimer’s disease · Samira Parhizkar · 2022 · 260 citations · Cited by this paper
  21. Mouse Models of Alzheimer’s Disease · Miyabishara Yokoyama · 2022 · 216 citations · Cited by this paper
  22. APOE4 is associated with cognitive and pathological heterogeneity in patients with Alzheimer’s disease: a systematic review · Sheina Emrani · 2020 · 204 citations · Cited by this paper
  23. An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery · Qin Huang · 2024 · 194 citations · Cited by this paper
  24. Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation · Maria Fe Lanfranco · 2021 · 172 citations · Cited by this paper
  25. Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist · Alexandra Litvinchuk · 2023 · 157 citations · Cited by this paper
  26. Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic Strategies · Mariana Pires · 2023 · 149 citations · Cited by this paper
  27. Association of APOE with tau-tangle pathology with and without β-amyloid · José M. Farfel · 2015 · 145 citations · Cited by this paper
  28. Differential Cellular Accumulation/Retention of Apolipoprotein E Mediated by Cell Surface Heparan Sulfate Proteoglycans · Zhong-Sheng Ji · 1998 · 133 citations · Cited by this paper
  29. Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis · Fan Liao · 2014 · 128 citations · Cited by this paper
  30. APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation · Laurie Arnaud · 2022 · 125 citations · Cited by this paper
  31. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models · Lingzhi Zhao · 2016 · 111 citations · Cited by this paper
  32. Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model · Alexandra Litvinchuk · 2021 · 89 citations · Cited by this paper
  33. APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease · Rosemary J. Jackson · 2024 · 81 citations · Cited by this paper
  34. APOE Christchurch‐mimetic therapeutic antibody reduces APOE‐mediated toxicity and tau phosphorylation · Claudia Mariño · 2023 · 44 citations · Cited by this paper
  35. RNAi-Based Gene Therapy Rescues Developmental and Epileptic Encephalopathy in a Genetic Mouse Model · Osasumwen V. Aimiuwu · 2020 · 37 citations · Cited by this paper
  36. The therapeutic implications of all-in-one AAV-delivered epigenome-editing platform in neurodegenerative disorders · Boris Kantor · 2024 · 36 citations · Cited by this paper
  37. Suppression and Replacement Gene Therapy for KCNH2 -Mediated Arrhythmias · Sahej Bains · 2022 · 28 citations · Cited by this paper
  38. Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing · Fumiyuki Hatanaka · 2024 · 24 citations · Cited by this paper
  39. AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer’s disease mice · Caner Günaydın · 2024 · 24 citations · Cited by this paper

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