Research map: Rutin as a multi-target anti-inflammatory phytochemical in arthritic disorders: pharmacological mechanisms and therapeutic potential

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  1. The JAK/STAT signaling pathway: from bench to clinic · Xiaoyi Hu · 2021 · 2632 citations · Cited by this paper
  2. REJENERA©, a multi-component bioflavonoid-based formula, alleviates osteoarthritis and provides chondroprotection by regulating the NLRP3-TXNIP-iNOS axis and inflammation: a comparative study with olive leaf nutraceuticals and ibuprofen · 2026 · Related
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  17. Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature · Ndivhuwo Muvhulawa · 2022 · 224 citations · Cited by this paper
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  19. JAK-STAT signaling in inflammation and stress-related diseases: implications for therapeutic interventions · Alexey Sarapultsev · 2023 · 219 citations · Cited by this paper
  20. Health benefits and limitations of rutin - A natural flavonoid with high nutraceutical value · Ravindra Semwal · 2021 · 178 citations · Cited by this paper
  21. The Beneficial Role of Rutin, A Naturally Occurring Flavonoid in Health Promotion and Disease Prevention: A Systematic Review and Update · Kanika Patel · 2019 · 148 citations · Cited by this paper
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  24. Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection · Shoaib Shoaib · 2023 · 122 citations · Cited by this paper
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  26. Rutin (Bioflavonoid) as Cell Signaling Pathway Modulator: Prospects in Treatment and Chemoprevention · Pratibha Pandey · 2021 · 110 citations · Cited by this paper
  27. Rutin and rutin-conjugated gold nanoparticles ameliorate collagen-induced arthritis in rats through inhibition of NF-κB and iNOS activation · Anum Gul · 2018 · 107 citations · Cited by this paper
  28. Rutin ameliorates gout via reducing XOD activity, inhibiting ROS production and NLRP3 inflammasome activation in quail · Hao Wu · 2022 · 73 citations · Cited by this paper
  29. Absorption of Quercetin and Rutin in Rat Small Intestine · Marina Carbonaro · 2005 · 72 citations · Cited by this paper
  30. Oleuropein or rutin consumption decreases the spontaneous development of osteoarthritis in the Hartley guinea pig · M.-N. Horcajada · 2014 · 67 citations · Cited by this paper
  31. Cyclodextrin-Modified CeO2 Nanoparticles as a Multifunctional Nanozyme for Combinational Therapy of Psoriasis · Lingyun Wu · 2020 · 64 citations · Cited by this paper
  32. Role of Nrf2 in rheumatoid arthritis · Swati Chadha · 2020 · 64 citations · Cited by this paper
  33. Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis · Zhifang Peng · 2024 · 62 citations · Cited by this paper
  34. Rutin: Family Farming Products’ Extraction Sources, Industrial Applications and Current Trends in Biological Activity Protection · Magaly Elizabeth Tobar-Delgado · 2023 · 61 citations · Cited by this paper
  35. Rutin protects rat articular chondrocytes against oxidative stress induced by hydrogen peroxide through SIRT1 activation · Ji‐Young Na · 2016 · 55 citations · Cited by this paper
  36. Rutin Attenuates Oxidative Stress and Proinflammatory Cytokine Level in Adjuvant Induced Rheumatoid Arthritis via Inhibition of NF-κB · Chong-ling Sun · 2017 · 52 citations · Cited by this paper
  37. Circulating immune cells and risk of osteosarcoma: a Mendelian randomization analysis · Li Lan · 2024 · 45 citations · Cited by this paper
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  39. Global, regional, and national burden of osteoarthritis from 1990 to 2021 and projections to 2035: A cross-sectional study for the Global Burden of Disease Study 2021 · Xiaoming Xie · 2025 · 42 citations · Cited by this paper

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