Research map: Sarsasapogenin Improves Pathological Phenotypes in MPTP/MPP+-Induced Parkinson’s Disease Models: Synergistic Actions of Neurite Outgrowth, Neurotransmitter Modulation, and Anti-Inflammation Back to the article
Papers in this map Protocol for the MPTP mouse model of Parkinson's disease · Vernice R. Jackson-Lewis · 2007 · 1139 citations · Cited by this paperNeural Correlates of Diagnostic-Relevant Emotional Processing in Schizophrenia and Major Depressive Disorder: Insights from a Replication of fMRI and Self-Report Scales · 2026 · RelatedTarget identification using drug affinity responsive target stability (DARTS) · Brett Lomenick · 2009 · 1119 citations · Cited by this paperLong-Term Orchestral String Learning and Event-Related Potentials of Inhibitory Control in Children From Disadvantaged Communities · 2026 · RelatedProjections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021 · Dongning Su · 2025 · 593 citations · Cited by this paperDl-3-n-Butylphthalide Protects Human Brain Microvascular Endothelial Cells Against Ischemic Injury Through Dual Modulation of HIF1α/VEGF-Mediated Angiogenesis and COX2-Mediated Inflammation · 2026 · RelatedAxon degeneration in Parkinson's disease · Robert E. 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Williams · 2021 · 329 citations · Cited by this paperGlymphatic-Related Alterations in Major Depressive Disorder and Treatment-Resistant Depression: Imaging Proxies, Mechanistic Links, and Therapeutic Opportunities · 2026 · RelatedIdentification of Direct Protein Targets of Small Molecules · Brett Lomenick · 2010 · 300 citations · Cited by this paperAtractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury · 2026 · RelatedRetrograde Axonal Degeneration in Parkinson Disease · Patricia A. Tagliaferro · 2016 · 281 citations · Cited by this paperA Capacitance-Based System for Measuring Licking Behaviour in Rodents With Sub-Second Precision · 2026 · RelatedBiology of Hsp47 (Serpin H1), a collagen-specific molecular chaperone · Shinya Ito · 2016 · 271 citations · Cited by this paperSingle-Cell and Integrative Analyses Uncover Therapeutic Potential of RFX1-Mediated Cuproptosis in PitNETs · 2026 · RelatedBiomarker of Neuroinflammation in Parkinson’s Disease · Tsai-Wei Liu · 2022 · 260 citations · Cited by this paperAlpha-Synuclein in Parkinson’s Disease: From Pathogenetic Dysfunction to Potential Clinical Application · Lingjia Xu · 2016 · 232 citations · Cited by this paperReassessment of subacute MPTP-treated mice as animal model of Parkinson's disease · Qiu-Shuang Zhang · 2017 · 212 citations · Cited by this paperInhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease · Lars Tönges · 2012 · 175 citations · Cited by this paperInteractome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α · Denisse Sepúlveda · 2018 · 174 citations · Cited by this paperBehavior, neurotransmitters and inflammation in three regimens of the MPTP mouse model of Parkinson's disease · Dirk W. Luchtman · 2009 · 166 citations · Cited by this paperThe potential role of neuroinflammation and transcription factors in Parkinson disease · Prafulla Chandra Tiwari · 2017 · 166 citations · Cited by this paperAlpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons · Jan Christoph Koch · 2015 · 148 citations · Cited by this paperInsight Into the Emerging Role of Striatal Neurotransmitters in the Pathophysiology of Parkinson’s Disease and Huntington’s Disease: A Review · Sumit Jamwal · 2018 · 131 citations · Cited by this paperNeuropathogenesis-on-chips for neurodegenerative diseases · Sarnai Amartumur · 2024 · 112 citations · Cited by this paperThe Proteasome Inhibition Model of Parkinson’s Disease · Eduard Bentea · 2016 · 111 citations · Cited by this paperMechanisms compensating for dopamine loss in early Parkinson disease · Jonathan M. Brotchie · 2009 · 103 citations · Cited by this paperChronic and progressive Parkinson's disease MPTP model in adult and aged mice · Ana B. Muñoz‐Manchado · 2015 · 94 citations · Cited by this paperIs Axonal Degeneration a Key Early Event in Parkinson’s Disease? · Zuzanna Kurowska · 2016 · 61 citations · Cited by this paperNeurochemical, histological, and behavioral profiling of the acute, sub‐acute, and chronic MPTP mouse model of Parkinsonʼs disease · Matteo Santoro · 2022 · 46 citations · Cited by this paperDopaminergic Axons: Key Recitalists in Parkinson’s Disease · Abhishek Kumar Mishra · 2021 · 44 citations · Cited by this paperChemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy · Nur Hanisah Mustafa · 2022 · 43 citations · Cited by this paperSarsasapogenin‐ AA 13 ameliorates Aβ‐induced cognitive deficits via improving neuroglial capacity on Aβ clearance and antiinflammation · Cui Huang · 2017 · 42 citations · Cited by this paperIdentification of Adenylate Kinase 5 as a Protein Target of Ginsenosides in Brain Tissues Using Mass Spectrometry-Based Drug Affinity Responsive Target Stability (DARTS) and Cellular Thermal Shift Assay (CETSA) Techniques · Feiyan Chen · 2022 · 41 citations · Cited by this paperSource: OpenAlex (CC0)