Research map: NLRC3 suppresses hepatocarcinogenesis by disrupting the HSP90-mediated TRAF6/MYC signalling activation

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  1. Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma · Adrian Ally · 2017 · 2610 citations · Cited by this paper
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  15. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB · Monika Schneider · 2012 · 352 citations · Cited by this paper
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  19. NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING · Lu Zhang · 2014 · 275 citations · Cited by this paper
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  21. NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer · Rajendra Karki · 2016 · 224 citations · Cited by this paper
  22. A hMTR4‐PDIA3P1‐miR‐125/124‐TRAF6 Regulatory Axis and Its Function in NF kappa B Signaling and Chemoresistance · Chen Xie · 2019 · 193 citations · Cited by this paper
  23. AFP promotes HCC progression by suppressing the HuR-mediated Fas/FADD apoptotic pathway · Tianke Chen · 2020 · 189 citations · Cited by this paper
  24. Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis · Pál Kaposi-Novák · 2009 · 188 citations · Cited by this paper
  25. TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6 · Chee-Kwee Ea · 2004 · 131 citations · Cited by this paper
  26. NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer · Rajendra Karki · 2017 · 130 citations · Cited by this paper
  27. Tumor Necrosis Factor Receptor–Associated Factor 6 Promotes Hepatocarcinogenesis by Interacting With Histone Deacetylase 3 to Enhance c‐Myc Gene Expression and Protein Stability · Hua Wu · 2019 · 126 citations · Cited by this paper
  28. NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding · Elif Eren · 2017 · 93 citations · Cited by this paper
  29. The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity · Toru Uchimura · 2018 · 82 citations · Cited by this paper
  30. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon · Xin Li · 2019 · 80 citations · Cited by this paper
  31. Overexpressed NLRC3 Acts as an Anti-Inflammatory Cytosolic Protein · Yetiş Gültekin · 2014 · 74 citations · Cited by this paper
  32. Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma · Jimmy Lee · 2018 · 65 citations · Cited by this paper
  33. NLRC3 expression in dendritic cells attenuates CD4+ T cell response and autoimmunity · Yuling Fu · 2019 · 51 citations · Cited by this paper
  34. Promising key genes associated with tumor microenvironments and prognosis of hepatocellular carcinoma · Long Pan · 2020 · 42 citations · Cited by this paper
  35. NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL‐6/JAK2/STAT3 pathway activation · Jianhua Kang · 2020 · 38 citations · Cited by this paper
  36. Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases · Deyi Sun · 2022 · 38 citations · Cited by this paper
  37. Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING · Blake R. Heath · 2023 · 35 citations · Cited by this paper
  38. Relationship between TRAF6 and deterioration of HCC: an immunohistochemical and in vitro study · Jianjun Li · 2016 · 34 citations · Cited by this paper
  39. The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation. · Ranjeny Thomas · 2005 · 33 citations · Cited by this paper

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