Research map: Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective

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Papers in this map

  1. Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants · Loredana Ruggeri · 2002 · 3404 citations · Cited by this paper
  2. Retroviral Transduction of Human CD4 + T Cells with Membrane-Attached IL-10 Generates Type 1-Like Regulatory T Cells · 2026 · Related
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  5. Role of hypoxia in cancer therapy by regulating the tumor microenvironment · Xinming Jing · 2019 · 2153 citations · Cited by this paper
  6. Prenatal Intraportal Delivery of Polymeric Nanoparticles to Fetal Rhesus Monkeys ( Macaca mulatta ) · 2026 · Related
  7. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer · Jeffrey S. Miller · 2005 · 1932 citations · Cited by this paper
  8. High Prevalence of Preexisting Neutralizing Antibodies Against Adeno-Associated Virus Capsids in Mongolian People with Hemophilia · 2026 · Related
  9. Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells · Zoltán Ivics · 1997 · 1448 citations · Cited by this paper
  10. Quantification of Lentiviral Vectors with Nucleic Acid Dyes · 2026 · Related
  11. CAR-NK cells: A promising cellular immunotherapy for cancer · Guozhu Xie · 2020 · 815 citations · Cited by this paper
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  13. TRUCKs: the fourth generation of CARs · Markus Martin Chmielewski · 2015 · 735 citations · Cited by this paper
  14. A Review of the Challenge of Pre-Existing Humoral Immunity in Adeno-Associated Virus Gene Therapy and Potential Solutions · 2026 · Related
  15. Cytokine activation induces human memory-like NK cells · Rizwan Romee · 2012 · 693 citations · Cited by this paper
  16. Capsid Engineering of Adeno-Associated Viruses for Targeted Gene Therapy in Kidney Diseases · 2026 · Related
  17. CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances · Karama Makni‐Maalej · 2023 · 623 citations · Cited by this paper
  18. Ethical and Regulatory Considerations for Developing Gene Therapies Involving Genome Editing · 2026 · Related
  19. Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial · David Marín · 2024 · 503 citations · Cited by this paper
  20. Helper-Dependent Adenoviral Vectors: Recent Advances and Emerging Applications · 2026 · Related
  21. CD4+ T cells in cancer · Daniel E. Speiser · 2023 · 497 citations · Cited by this paper
  22. CIS is a potent checkpoint in NK cell–mediated tumor immunity · Rebecca B. Delconte · 2016 · 400 citations · Cited by this paper
  23. ErbB2/HER2-Specific NK Cells for Targeted Therapy of Glioblastoma · Congcong Zhang · 2015 · 394 citations · Cited by this paper
  24. Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy · Qiang Lü · 2024 · 358 citations · Cited by this paper
  25. Selective Inhibition of Tumor Growth by Clonal NK Cells Expressing an ErbB2/HER2-Specific Chimeric Antigen Receptor · Kurt Schönfeld · 2014 · 354 citations · Cited by this paper
  26. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity · Zhu Huang · 2020 · 348 citations · Cited by this paper
  27. Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis · Xiaobing Wang · 2024 · 315 citations · Cited by this paper
  28. Chimeric Antigen Receptor-Engineered NK-92 Cells: An Off-the-Shelf Cellular Therapeutic for Targeted Elimination of Cancer Cells and Induction of Protective Antitumor Immunity · Congcong Zhang · 2017 · 311 citations · Cited by this paper
  29. Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells · May Daher · 2020 · 301 citations · Cited by this paper
  30. Tumor microenvironment remodeling and tumor therapy based on M2-like tumor associated macrophage-targeting nano-complexes · Shulan Han · 2021 · 280 citations · Cited by this paper
  31. A phase I trial of adoptive transfer of allogeneic natural killer cells in patients with advanced non-small cell lung cancer · Eleni G. Iliopoulou · 2010 · 279 citations · Cited by this paper
  32. Human γδ T lymphocytes induce robust NK cell–mediated antitumor cytotoxicity through CD137 engagement · Amudhan Maniar · 2010 · 215 citations · Cited by this paper
  33. Pre-emptive immunotherapy with purified natural killer cells after haploidentical SCT: a prospective phase II study in two centers · Marc Stern · 2012 · 176 citations · Cited by this paper
  34. Ageing is associated with a decline in peripheral blood CD56bright NK cells · Shivani M Chidrawar · 2006 · 165 citations · Cited by this paper
  35. Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK Cells · Michael Alexander Morgan · 2020 · 154 citations · Cited by this paper
  36. Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse · Roman M. Shapiro · 2022 · 149 citations · Cited by this paper
  37. Clinical Grade Purification and Expansion of NK Cell Products for an Optimized Manufacturing Protocol · Ulrike Koehl · 2013 · 143 citations · Cited by this paper
  38. Potential solutions for manufacture of CAR T cells in cancer immunotherapy · Ulrich Blache · 2022 · 142 citations · Cited by this paper
  39. Intracranial injection of natural killer cells engineered with a HER2-targeted chimeric antigen receptor in patients with recurrent glioblastoma · Michael C. Burger · 2023 · 140 citations · Cited by this paper

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