Research map: Immune Dysregulation in Down Syndrome: Implications for Infectious Susceptibility and Vaccine Response

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Papers in this map

  1. Innate or Adaptive Immunity? The Example of Natural Killer Cells · Eric D. Vivier · 2011 · 2820 citations · Cited by this paper
  2. Genetic Diagnosis and Identification of a Novel De Novo RELA Variant in Familial Behçet-like Autoinflammatory Syndrome Type 3: A Case Report · 2026 · Related
  3. WHO estimates of the causes of death in children · Jennifer Bryce · 2005 · 2128 citations · Cited by this paper
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  5. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis · You Li · 2022 · 2024 citations · Cited by this paper
  6. Hypoproteinemia and Hypogammaglobulinemia Due to a Homozygous FCGRT Mutation · 2026 · Related
  7. Complement System Part I – Molecular Mechanisms of Activation and Regulation · Nicolas S. Merle · 2015 · 1624 citations · Cited by this paper
  8. Disseminated Tuberculosis and Early-Onset SLE in a Child with a Novel STAT1 Gain-of-Function Mutation: a Case Report · 2026 · Related
  9. Raising the NKT cell family · Dale Ian Godfrey · 2010 · 654 citations · Cited by this paper
  10. Humoral Immune Abnormalities in Transient Childhood Neutropenia: Insights From a 10-year Cohort Study in a Tertiary Center · 2026 · Related
  11. B-cell biology and development · Kathrin Pieper · 2013 · 637 citations · Cited by this paper
  12. Phenotypic Heterogeneity in CD40 Ligand Deficiency: Long-term Follow-up of a Patient with the c.156G > A Splice Variant · 2026 · Related
  13. Infections and immunodeficiency in Down syndrome · G. S. Ram · 2011 · 470 citations · Cited by this paper
  14. First-in-Human, Phase 1, Randomized, Double-Blind, Placebo-Controlled Study of TNX-1500, an Fc-Modified anti-CD154 Monoclonal Antibody, Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses in Healthy Adults · 2026 · Related
  15. Trisomy 21 consistently activates the interferon response · Kelly D. Sullivan · 2016 · 397 citations · Cited by this paper
  16. Antigen Microarray Reveals Broad and Subclinical Autoimmunity in Patients with Inborn Errors of Immunity · 2026 · Related
  17. Erratum: JAK inhibition as a therapeutic strategy for immune and inflammatory diseases · Daniella M. Schwartz · 2017 · 393 citations · Cited by this paper
  18. Acute Leukemia in Children with Down Syndrome: A Report from the Hellenic HESPHO Group · 2025 · Related
  19. Alzheimer's disease associated with Down syndrome: a genetic form of dementia · Juan Fortea · 2021 · 374 citations · Cited by this paper
  20. Immunologic profiles and infection patterns in patients with down syndrome: A retrospective review · 2025 · Related
  21. Principles of Infectious Diseases: Transmission, Diagnosis, Prevention, and Control · Jean Maguire van Seventer · 2016 · 303 citations · Cited by this paper
  22. Broadly targeted CD8 + T cell responses restricted by major histocompatibility complex E · Scott G. Hansen · 2016 · 301 citations · Cited by this paper
  23. Estimates of the live births, natural losses, and elective terminations with Down syndrome in the United States · Gert de Graaf · 2015 · 294 citations · Cited by this paper
  24. Intrinsic defect of the immune system in children with Down syndrome: a review · Maaike Kusters · 2009 · 253 citations · Cited by this paper
  25. Trisomy 21 causes changes in the circulating proteome indicative of chronic autoinflammation · Kelly D. Sullivan · 2017 · 247 citations · Cited by this paper
  26. Etiology of Down syndrome: Evidence for consistent association among altered meiotic recombination, nondisjunction, and maternal age across populations · Sujay Ghosh · 2009 · 217 citations · Cited by this paper
  27. Late stages of T cell maturation in the thymus involve NF-κB and tonic type I interferon signaling · Yan Xing · 2016 · 216 citations · Cited by this paper
  28. Aire Enforces Immune Tolerance by Directing Autoreactive T Cells into the Regulatory T Cell Lineage · Sven Malchow · 2016 · 209 citations · Cited by this paper
  29. Down Syndrome: A Novel Risk Factor for Respiratory Syncytial Virus Bronchiolitis— A Prospective Birth-Cohort Study · Beatrijs L.P. Bloemers · 2007 · 204 citations · Cited by this paper
  30. Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity · Paula Araya · 2019 · 202 citations · Cited by this paper
  31. Estimation of the number of people with Down syndrome in Europe · Gert de Graaf · 2020 · 185 citations · Cited by this paper
  32. Human STAT1 Gain-of-Function Heterozygous Mutations: Chronic Mucocutaneous Candidiasis and Type I Interferonopathy · Satoshi Okada · 2020 · 178 citations · Cited by this paper
  33. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease · Mengmeng Jin · 2022 · 178 citations · Cited by this paper
  34. Immune Dysregulation in Children With Down Syndrome · Dean Huggard · 2020 · 151 citations · Cited by this paper
  35. Respiratory morbidity of hospitalized children with Trisomy 21 · JM Hilton · 1999 · 147 citations · Cited by this paper
  36. Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells · Louise Malle · 2023 · 130 citations · Cited by this paper
  37. Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system · Beatrijs L.P. Bloemers · 2010 · 123 citations · Cited by this paper
  38. Medical vulnerability of individuals with Down syndrome to severe COVID-19–data from the Trisomy 21 Research Society and the UK ISARIC4C survey · Anke Hüls · 2021 · 118 citations · Cited by this paper
  39. Precocious aging of the immune system in Down syndrome: Alteration of b lymphocytes, T-lymphocyte subsets, and cells with natural killer markers · Andrea Cossarizza · 2005 · 115 citations · Cited by this paper

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