Research map: Drug-opposite neuroadaptation and breakthrough pain

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Papers in this map

  1. Drug Abuse: Hedonic Homeostatic Dysregulation · George F. Koob · 1997 · 2560 citations · Cited by this paper
  2. Associations of long-term exposure to multiple air pollutants with chronic pain among middle-aged and older adults: a retrospective cohort study in China · 2026 · Related
  3. An opponent-process theory of motivation: I. Temporal dynamics of affect. · Richard L. Solomon · 1974 · 1727 citations · Cited by this paper
  4. A critical role for α7 nicotinic acetylcholine receptor signaling in myeloid lineage cells in chronic neuropathic and inflammatory pain responses · 2026 · Related
  5. Pain Management: A Fundamental Human Right · Frank Patrick Brennan · 2007 · 1032 citations · Cited by this paper
  6. Empowered Relief for Youth: Development, feasibility and early effectiveness of a single session pain relief skills class · 2026 · Related
  7. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction · George F. Koob · 2005 · 982 citations · Cited by this paper
  8. Pre-surgical quantitative sensory testing and post-surgical pain among adolescents undergoing spinal fusion surgery: A longitudinal cohort study · 2026 · Related
  9. Breakthrough pain: definition, prevalence and characteristics · Russell K. Portenoy · 1990 · 927 citations · Cited by this paper
  10. Inhibition of endocannabinoid catabolizing enzymes MAGL and FAAH reduces the activity of CaV3 channels in nociceptors and pain hypersensitivity in a rat model of spinal cord injury · 2026 · Related
  11. Cellular and Synaptic Adaptations Mediating Opioid Dependence · John T. Williams · 2001 · 847 citations · Cited by this paper
  12. Structural and individualized racism drives racial disparities in chronic low back pain: A cross-sectional serial mediation analysis · 2026 · Related
  13. Evidence from rats that morphine tolerance is a learned response. · Shepard Siegel · 1975 · 660 citations · Cited by this paper
  14. The endometriosis pain course: Exploring predictors of clinical response to an internet-delivered psychological pain management program for endometriosis · 2026 · Related
  15. Opioid-induced Hyperalgesia in Humans · Larry F. Chu · 2008 · 582 citations · Cited by this paper
  16. Effects of putative chronic pain models on locomotor activity in female and male mice · 2026 · Related
  17. Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement · George F. Koob · 2019 · 499 citations · Cited by this paper
  18. Effect of self-management interventions on high impact chronic pain prevalence · 2026 · Related
  19. Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy · Jianren Mao · 2002 · 466 citations · Cited by this paper
  20. Spontaneously hypertensive rats exhibit reduced facial pain sensitivity with altered electrophysiology and transcriptomics in the trigeminal ganglia · 2026 · Related
  21. Dynorphin Promotes Abnormal Pain and Spinal Opioid Antinociceptive Tolerance · Todd W. Vanderah · 2000 · 345 citations · Cited by this paper
  22. Drug Addiction: Hyperkatifeia/Negative Reinforcement as a Framework for Medications Development · George F. Koob · 2020 · 342 citations · Cited by this paper
  23. Clarifying the roles of homeostasis and allostasis in physiological regulation. · Douglas S. Ramsay · 2014 · 331 citations · Cited by this paper
  24. Addiction and stress: An allostatic view · George F. Koob · 2018 · 316 citations · Cited by this paper
  25. Heroin "Overdose" Death: Contribution of Drug-Associated Environmental Cues · Shepard Siegel · 1982 · 306 citations · Cited by this paper
  26. When pain gets stuck: the evolution of pain chronification and treatment resistance · David Borsook · 2018 · 284 citations · Cited by this paper
  27. Mechanisms of opioid-induced pain and antinociceptive tolerance: descending facilitation and spinal dynorphin · Todd W. Vanderah · 2001 · 270 citations · Cited by this paper
  28. Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure · Michael H. Ossipov · 2005 · 260 citations · Cited by this paper
  29. Conditioned Narcotic Withdrawal in Humans · Charles P. O’Brien · 1977 · 241 citations · Cited by this paper
  30. Opioid therapy for chronic pain in the United States: Promises and perils · Mark Daniel Sullivan · 2013 · 233 citations · Cited by this paper
  31. Opioids, Pain, the Brain, and Hyperkatifeia: A Framework for the Rational Use of Opioids for Pain · Joseph Shurman · 2010 · 219 citations · Cited by this paper
  32. Evidence for opiate-activated NMDA processes masking opiate analgesia in rats · Evelyne Célèrier · 1999 · 186 citations · Cited by this paper
  33. Hyperalgesia during Naloxone-Precipitated Withdrawal from Morphine Is Associated with Increased On-Cell Activity in the Rostral Ventromedial Medulla · Joshua B. Bederson · 1990 · 183 citations · Cited by this paper
  34. Should protracted withdrawal from drugs be included in DSM-IV? · Sally L. Satel · 1993 · 159 citations · Cited by this paper
  35. Biological consequences of drug administration: Implications for acute and chronic tolerance. · Douglas S. Ramsay · 1997 · 158 citations · Cited by this paper
  36. Pavlovian psychopharmacology: The associative basis of tolerance. · Shepard Siegel · 2000 · 149 citations · Cited by this paper
  37. Unifying Perspectives of the Mechanisms Underlying the Development of Tolerance and Physical Dependence to Opioids · DAVID A H B TAYLOR · 2001 · 137 citations · Cited by this paper
  38. Applying laboratory research: Drug anticipation and the treatment of drug addiction. · Shepard Siegel · 2002 · 123 citations · Cited by this paper
  39. Breakthrough cancer pain: twenty-five years of study · Sebastiano Mercadante · 2016 · 111 citations · Cited by this paper

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