Research map: Effects of Antioxidant DI-3-N-Butylphthalide on Hemorrhagic Transformation Assessed by Propensity Score Matching in a Real-World Thrombolyzed Ischemic Stroke Patient Setting

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  1. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 · Valery L. Feigin · 2021 · 8115 citations · Cited by this paper
  2. Multimodal Risk Stratification Clue of Carotid Bifurcation Plaques: A Cross-Sectional Observational Study of Vector Flow Imaging, Plaque-RADS, and Clinical Factors · 2026 · Related
  3. Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) · Werner Hacke · 1998 · 3687 citations · Cited by this paper
  4. Circulating Microglia-derived Extracellular Vesicles Predict Recovery After Rehabilitation in Stroke Survivors · 2026 · Related
  5. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials · Jonathan Emberson · 2014 · 2802 citations · Cited by this paper
  6. Efficacy and Mechanisms of Combined Central-Peripheral Magnetic Stimulation on Prefrontal-Sensorimotor Cortex Connectivity in Post-Stroke Dysphagia after Supratentorial Stroke: A Randomized, Single-Blind, Parallel-Controlled Trial · 2026 · Related
  7. Stroke Severity in Atrial Fibrillation · Huey‐Juan Lin · 1996 · 1395 citations · Cited by this paper
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  9. Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era · Marc Fisher · 2022 · 201 citations · Cited by this paper
  10. Quantitative Cerebrovascular Analysis for Improved Prediction of Post-Stroke Complications · 2026 · Related
  11. Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke · Anxin Wang · 2023 · 148 citations · Cited by this paper
  12. Association Between Inflammatory Biomarkers And Carotid Ultrasound Parameters In The Northern Manhattan Stroke Study · 2026 · Related
  13. Frequency and risk factors for spontaneous hemorrhagic transformation of cerebral infarction · Richard I. Lindley · 2004 · 128 citations · Cited by this paper
  14. Non-Linear Temporal Dynamics of Endothelial Progenitor Cells After Stroke: Associations with Perfusion Imaging, ASPECTs and Functional Outcome · 2026 · Related
  15. Metabolism and Pharmacokinetics of 3-n-Butylphthalide (NBP) in Humans: The Role of Cytochrome P450s and Alcohol Dehydrogenase in Biotransformation · Xingxing Diao · 2012 · 121 citations · Cited by this paper
  16. Cytotoxic Edema and Intra-parenchymal Hemorrhage: A Mediated Pathway to Mortality and Functional Outcome in Cerebral Venous Sinus Thrombosis- A sub-analysis of the CLOT-VENUS Registry · 2026 · Related
  17. dl-3n-butylphthalide prevents stroke via improvement of cerebral microvessels in RHRSP · Chun-Ling Liu · 2007 · 120 citations · Cited by this paper
  18. A Segatella Copri-centered Gut Microbiota-mediated Metabolic Dysregulation Associated with Transition from Asymptomatic to Symptomatic Intracranial Atherosclerosis · 2026 · Related
  19. Early Disruption of the Blood–Brain Barrier After Thrombolytic Therapy Predicts Hemorrhage in Patients With Acute Stroke · Andreas Kastrup · 2008 · 118 citations · Cited by this paper
  20. AI-Guided Patient-Derived Endothelial Modeling Identifies a Reversible Moyamoya-Specific miRNA Deficiency Corrected by Stem Cell-Extracellular Vesicles · 2026 · Related
  21. DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress · Beini Wang · 2021 · 102 citations · Cited by this paper
  22. Antiplatelet and Antithrombotic Activity of L-3-n-butylphthalide in Rats · Ying Peng · 2004 · 81 citations · Cited by this paper
  23. Sequential computerized tomographic appearance of strokes. · A. M. Hakim · 1983 · 80 citations · Cited by this paper
  24. Thrombolysis in acute ischaemic stroke: an update · Zahid Zaheer · 2011 · 72 citations · Cited by this paper
  25. Effects of Recombinant Tissue Plasminogen Activator After Intraluminal Thread Occlusion in Mice: Role of Hemodynamic Alterations · E. Kilic · 2001 · 70 citations · Cited by this paper
  26. Tissue‐plasminogen activator‐induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt · Ertuğrul Kılıç · 2005 · 69 citations · Cited by this paper
  27. Prognostic significance of the clinical and radiological haemorrhagic transformation subtypes in acute ischaemic stroke: A systematic review and meta‐analysis · Jinfeng He · 2022 · 50 citations · Cited by this paper
  28. Mobilization of Circulating Endothelial Progenitor Cells by dl-3-n-Butylphthalide in Acute Ischemic Stroke Patients · Hongru Zhao · 2016 · 49 citations · Cited by this paper
  29. Emergency Care of Patients with Acute Ischemic Stroke · Adeel Shakil Zubair · 2021 · 39 citations · Cited by this paper
  30. dl -3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2synthesis and phosphodiesterase · Jianqin Ye · 2015 · 38 citations · Cited by this paper
  31. Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog · Mei-jie Dai · 2023 · 37 citations · Cited by this paper
  32. Lipid Profile, Lipid-lowering Medications, and Intracerebral Hemorrhage After tPA in Get With The Guidelines–Stroke · Steven Russell Messe · 2013 · 34 citations · Cited by this paper
  33. Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia–Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway · Meilin Sun · 2024 · 34 citations · Cited by this paper
  34. Intravenous thrombolytic therapy for acute ischemic stroke in Hubei, China: a survey of thrombolysis rate and barriers · Yanfeng Zhou · 2019 · 33 citations · Cited by this paper
  35. Decitabine enhances chemosensitivity of early T-cell precursor-acute lymphoblastic leukemia cell lines and patient-derived samples · Benjamin Y. Lu · 2016 · 31 citations · Cited by this paper
  36. Effects of dl-3-n-butylphthalide on production of TXB2 and 6-keto-PGF1 alpha in rat brain during focal cerebral ischemia and reperfusion. · Zhao-Zhong Chong · 1997 · 23 citations · Cited by this paper
  37. DL-3-n-butylphthalide for acute ischemic stroke: An updated systematic review and meta-analysis of randomized controlled trials · Huan Wang · 2022 · 22 citations · Cited by this paper
  38. The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activitiesin vitro · Piotr Gołąb · 2014 · 20 citations · Cited by this paper
  39. The novel targets of DL-3-n-butylphthalide predicted by similarity ensemble approach in combination with molecular docking study · Yan Wang · 2017 · 20 citations · Cited by this paper

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