Research map: The Vicious Cycle of Biofilm, Host Inflammation and Microvascular Insufficiency in Venous Leg Ulcers

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Papers in this map

  1. A Randomized Trial of Early Endovenous Ablation in Venous Ulceration · Manjit Gohel · 2018 · 392 citations · Cited by this paper
  2. DCDC2C Protein Expression in Human Spermatozoa: A Potential Molecular Marker for Asthenozoospermia · 2026 · Related
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  5. Current Insights into the Role of HIF-1 in Cutaneous Wound Healing · Efstathia Andrikopoulou · 2011 · 78 citations · Cited by this paper
  6. Agreement of Electrolyte Measurements Between Arterial Blood Gas Analyzers and Central Laboratories in Critically Ill Patients with Acute Kidney Injury · 2026 · Related
  7. The venous ulcer continues to be a clinical challenge: an update · Ting Xie · 2018 · 73 citations · Cited by this paper
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  9. An appraisal of vascular endothelial growth factor (VEGF): the dynamic molecule of wound healing and its current clinical applications · Aakansha Giri Goswami · 2022 · 71 citations · Cited by this paper
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  11. Antimicrobial Biomaterials for Chronic Wound Care · Adrian Miron · 2023 · 69 citations · Cited by this paper
  12. Impact of the COVID-19 Pandemic on Primary Care Referral Patterns and Resource Utilization in a Hospital Emergency Department: A Comparative Pre- and Later-Pandemic Study · 2026 · Related
  13. Long-term Clinical and Cost-effectiveness of Early Endovenous Ablation in Venous Ulceration · Manjit Gohel · 2020 · 59 citations · Cited by this paper
  14. Improved Prognostic Staging in Endometrial Cancer: Clinical Impact of Aggressive Subtypes in a Multicenter Cohort · 2026 · Related
  15. Chronic venous disease – Part II: Proteolytic biomarkers in wound healing · Daniela Ligi · 2016 · 56 citations · Cited by this paper
  16. Lomerizine Prophylaxis for Pediatric Migraine: Efficacy and Predictors of Treatment Response—A Retrospective Cohort Study · 2026 · Related
  17. Treatment of Chronic Venous Ulcers With Heterologous Fibrin Sealant: A Phase I/II Clinical Trial · Luciana Patrícia Fernandes Abbade · 2021 · 46 citations · Cited by this paper
  18. Factors Associated with Clinically Meaningful Pain Reduction Following Phase-I Complex Decongestive Therapy in Breast Cancer-Related Lymphedema · 2026 · Related
  19. Evaluation of LL ‐37 in healing of hard‐to‐heal venous leg ulcers: A multicentric prospective randomized placebo‐controlled clinical trial · Margit Mahlapuu · 2021 · 41 citations · Cited by this paper
  20. Beyond the Steroid Trial: A Scoping Review of Biomarkers for Pediatric Nephrotic Syndrome · 2026 · Related
  21. Molecular Determinants of Chronic Venous Disease: A Comprehensive Review · Davide Dalla Costa · 2023 · 41 citations · Cited by this paper
  22. Baseline factors affecting closure of venous leg ulcers · William A. Marston · 2017 · 28 citations · Cited by this paper
  23. Wound Healing by Allogeneic Transplantation of Specific Subpopulation From Human Umbilical Cord Mesenchymal Stem Cells · María Belén Palma · 2021 · 28 citations · Cited by this paper
  24. Novel Diagnostic Technologies and Therapeutic Approaches Targeting Chronic Wound Biofilms and Microbiota · Vivien Chen · 2022 · 28 citations · Cited by this paper
  25. Efficacy of topical cadexomer iodine treatment in chronic wounds: Systematic review and meta‐analysis of comparative clinical trials · Kevin Y. Woo · 2021 · 27 citations · Cited by this paper
  26. Narrative Review of the Pathogenesis of Stasis Dermatitis: An Inflammatory Skin Manifestation of Venous Hypertension · Jonathan I. Silverberg · 2023 · 27 citations · Cited by this paper
  27. Variations in study outcomes relative to intention‐to‐treat and per‐protocol data analysis techniques in the evaluation of efficacy for treatment of venous leg ulcers with dehydrated human amnion/chorion membrane allograft · Christian Bianchi · 2019 · 21 citations · Cited by this paper
  28. What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing · Elizabeth C. Townsend · 2024 · 20 citations · Cited by this paper
  29. Multi‐drug resistant Staphylococcus epidermidis from chronic wounds impair healing in human wound model · Miroslav Dinić · 2024 · 16 citations · Cited by this paper
  30. A prospective clinical trial evaluating changes in the wound microenvironment in patients with chronic venous leg ulcers treated with a hypothermically stored amniotic membrane · John Patrick McQuilling · 2021 · 15 citations · Cited by this paper
  31. The wound microbiome in chronic wounds: a biomarker and therapeutic target · Bartosz Molasy · 2026 · 14 citations · Cited by this paper
  32. Homocysteine and Inflammatory Cytokines in the Clinical Assessment of Infection in Venous Leg Ulcers · Ilaria Cavallo · 2022 · 13 citations · Cited by this paper
  33. Improving outcomes for patients with hard-to-heal wounds following adoption of the Wound Hygiene Protocol: real-world evidence · Rachel Torkington-Stokes · 2024 · 12 citations · Cited by this paper
  34. An Open-Label, Proof-of-Concept Study Assessing the Effects of Bromelain-Based Enzymatic Debridement on Biofilm and Microbial Loads in Patients With Venous Leg Ulcers and Diabetic Foot Ulcers · Robert Snyder · 2023 · 10 citations · Cited by this paper
  35. The use of medicinal plants in venous ulcers: a systematic review with meta‐analysis · Anderson Leite Freitas · 2017 · 9 citations · Cited by this paper
  36. Effectiveness of an enhanced silver-containing dressing in hard-to-heal venous leg ulcers: a randomised controlled trial · Stefania Beraldo · 2025 · 9 citations · Cited by this paper
  37. Associations Among Wound-Related Factors Including Biofilm, Wound-Related Symptoms and Systemic Inflammation in Older Adults with Chronic Venous Leg Ulcers · Junglyun Kim · 2024 · 8 citations · Cited by this paper
  38. Virtual reality as a promising method of pain relief in patients with venous leg ulcers · Kinga Spyrka · 2024 · 7 citations · Cited by this paper
  39. Virulence and Drug-Resistance of Staphylococcus aureus Strains Isolated from Venous Ulcers in Polish Patients · Mateusz Gajda · 2021 · 6 citations · Cited by this paper

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