Research map: NLRC3 enhances antitumor immunity by specifically negatively regulating M-MDSCs in a STING-dependent manner

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Papers in this map

  1. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling · Hiroki Ishikawa · 2008 · 3600 citations · Cited by this paper
  2. Macrophage CCRL2 promotes NLRP3 inflammasome activation to exacerbate atherosclerosis · 2026 · Related
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  7. γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer · Pin Wu · 2014 · 629 citations · Cited by this paper
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  9. Host STING-dependent MDSC mobilization drives extrinsic radiation resistance · Hua Laura Liang · 2017 · 498 citations · Cited by this paper
  10. Cathepsin C orchestrates RSV-induced asthma exacerbation through the dual effect of monocyte-derived macrophages · 2026 · Related
  11. Myeloid-Derived Suppressor Cells · Katherine H. Parker · 2015 · 485 citations · Cited by this paper
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  13. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB · Monika Schneider · 2012 · 352 citations · Cited by this paper
  14. Defining the rules of engagement: B cells, antibodies and cancer control · 2026 · Related
  15. Trial watch: STING agonists in cancer therapy · Julie Le Naour · 2020 · 293 citations · Cited by this paper
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  17. NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING · Lu Zhang · 2014 · 275 citations · Cited by this paper
  18. TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy · 2026 · Related
  19. NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer · Rajendra Karki · 2016 · 224 citations · Cited by this paper
  20. The Parkinson’s disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections · 2026 · Related
  21. ΔNp63-driven recruitment of myeloid-derived suppressor cells promotes metastasis in triple-negative breast cancer · Sushil Kumar · 2018 · 203 citations · Cited by this paper
  22. STING agonist therapy in combination with PD-1 immune checkpoint blockade enhances response to carboplatin chemotherapy in high-grade serous ovarian cancer · Abdi Ghaffari · 2018 · 197 citations · Cited by this paper
  23. Tumor-induced myeloid-derived suppressor cells promote tumor progression through oxidative metabolism in human colorectal cancer · Li-Ying OuYang · 2015 · 191 citations · Cited by this paper
  24. Myeloid-derived suppressor cells in cancer: therapeutic targets to overcome tumor immune evasion · Junli Lu · 2024 · 165 citations · Cited by this paper
  25. CATERPILLER 16.2 (CLR16.2), a Novel NBD/LRR Family Member That Negatively Regulates T Cell Function · Brian J. Conti · 2005 · 162 citations · Cited by this paper
  26. NLRC3 regulates cellular proliferation and apoptosis to attenuate the development of colorectal cancer · Rajendra Karki · 2017 · 130 citations · Cited by this paper
  27. A RIPK3-PGE2 Circuit Mediates Myeloid-Derived Suppressor Cell–Potentiated Colorectal Carcinogenesis · Guifang Yan · 2018 · 126 citations · Cited by this paper
  28. Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy · Huan Song · 2025 · 106 citations · Cited by this paper
  29. The Innate Immune Sensor NLRC3 Acts as a Rheostat that Fine-Tunes T Cell Responses in Infection and Autoimmunity · Toru Uchimura · 2018 · 82 citations · Cited by this paper
  30. Viral DNA Binding to NLRC3, an Inhibitory Nucleic Acid Sensor, Unleashes STING, a Cyclic Dinucleotide Receptor that Activates Type I Interferon · Xin Li · 2019 · 80 citations · Cited by this paper
  31. The Development and Homing of Myeloid-Derived Suppressor Cells: From a Two-Stage Model to a Multistep Narrative · Nathan Karin · 2020 · 73 citations · Cited by this paper
  32. NLRC3 negatively regulates CD4+ T cells and impacts protective immunity during Mycobacterium tuberculosis infection · Shengfeng Hu · 2018 · 67 citations · Cited by this paper
  33. miR‐190b promotes tumor growth and metastasis via suppressing NLRC3 in bladder carcinoma · Zhaohui Chen · 2020 · 48 citations · Cited by this paper
  34. The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production · Aaron M. Tocker · 2017 · 42 citations · Cited by this paper
  35. NLRC3 silencing accelerates the invasion of hepatocellular carcinoma cell via IL‐6/JAK2/STAT3 pathway activation · Jianhua Kang · 2020 · 38 citations · Cited by this paper
  36. Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases · Deyi Sun · 2022 · 38 citations · Cited by this paper
  37. RNF213 promotes Treg cell differentiation by facilitating K63-linked ubiquitination and nuclear translocation of FOXO1 · Xiaofan Yang · 2024 · 34 citations · Cited by this paper
  38. NLRC3 promotes host resistance against Pseudomonas aeruginosa-induced keratitis by promoting the degradation of IRAK1 · Litao Guo · 2017 · 21 citations · Cited by this paper
  39. USP12 positively regulates M‐MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65 · Xiaoxia Zhan · 2022 · 21 citations · Cited by this paper

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