Research map: Leveraging peptides for targeted protein degradation

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Papers in this map

  1. Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation · Kathleen M. Sakamoto · 2001 · 2576 citations · Cited by this paper
  2. BioPROTACs: a promising approach for targeted protein degradation · Yuyang Li · 2026 · Cites this paper
  3. Zi Shen decoction inhibits non-small cell lung cancer progression by regulating macrophage polarization via the gut microbiota · 2026 · Related
  4. Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance · Ralph M. Steinman · 2002 · 1165 citations · Cited by this paper
  5. Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study · 2026 · Related
  6. Targeted protein degradation: mechanisms, strategies and application · Lin Zhao · 2022 · 972 citations · Cited by this paper
  7. Integrating crystal engineering with PEG6000 conjugation to formulate advanced solid dispersions of febuxostat for gout management · 2026 · Related
  8. Protein degraders enter the clinic — a new approach to cancer therapy · Deborah Chirnomas · 2023 · 642 citations · Cited by this paper
  9. Shanhuang Jiangzhi tablets mitigate atherosclerosis by modulating macrophage polarization and inhibiting foam cell formation via the ROS/TLR4/NF-κB pathway · 2026 · Related
  10. Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1 · Adam D. Cotton · 2021 · 543 citations · Cited by this paper
  11. Nanotechnology-enabled targeting strategies for neurodegenerative disorders: role of functionalized nanoparticles · 2026 · Related
  12. Chemical Genetic Control of Protein Levels: Selective in Vivo Targeted Degradation · John S. Schneekloth · 2004 · 491 citations · Cited by this paper
  13. Metformin as a multi-target modulator of atherosclerosis: integrated regulation of Nrf2/KLF2, mitochondrial homeostasis, inflammation, ferroptosis, and innate immunity · 2026 · Related
  14. Targeted Protein Degradation: from Chemical Biology to Drug Discovery · Philipp M. Cromm · 2017 · 431 citations · Cited by this paper
  15. The impact of compaction by pellet type, spatial arrangement and drug release on MUPS tablets · 2026 · Related
  16. Targeted protein degradation: from mechanisms to clinic · Jonathan M. Tsai · 2024 · 420 citations · Cited by this paper
  17. A GelMA hydrogel co-loaded with resveratrol, 18-β-glycyrrhetinic acid, and berberine for the combination therapy of infected wounds · 2026 · Related
  18. Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation · Kathleen M. Sakamoto · 2003 · 419 citations · Cited by this paper
  19. A novel Platycladus orientalis essential oil with functional properties: antioxidant defense, cognitive improvement, and immune enhancement for potential nutraceutical use · 2026 · Related
  20. Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation · Yu Chen · 2022 · 312 citations · Cited by this paper
  21. Rutin enhances the analgesic efficacy of low-dose pregabalin without sedative side effects in a rat model of chronic constriction injury · 2026 · Related
  22. Targeted protein degradation: advances in drug discovery and clinical practice · Guangcai Zhong · 2024 · 309 citations · Cited by this paper
  23. Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway · Mengchen Lu · 2018 · 300 citations · Cited by this paper
  24. Stapled Helical Peptides Bearing Different Anchoring Residues · Xiang Li · 2020 · 292 citations · Cited by this paper
  25. Current strategies in extending half-lives of therapeutic proteins · Rahela Zaman · 2019 · 290 citations · Cited by this paper
  26. Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein · Peter O. Bauer · 2010 · 277 citations · Cited by this paper
  27. Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation · Tingting Chu · 2016 · 248 citations · Cited by this paper
  28. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation · Xuelai Fan · 2014 · 227 citations · Cited by this paper
  29. Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer · Agustı́n Rodrı́guez-González · 2008 · 212 citations · Cited by this paper
  30. Peptide‐based therapeutic cancer vaccine: Current trends in clinical application · Wensi Liu · 2021 · 209 citations · Cited by this paper
  31. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras G12D in pancreatic cancer · Kathleen M. McAndrews · 2021 · 208 citations · Cited by this paper
  32. Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs · John F. Hines · 2013 · 175 citations · Cited by this paper
  33. A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer · Hongwei Liao · 2020 · 155 citations · Cited by this paper
  34. Designed endocytosis-inducing proteins degrade targets and amplify signals · Buwei Huang · 2024 · 144 citations · Cited by this paper
  35. Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α · Yan‐Hong Jiang · 2017 · 121 citations · Cited by this paper
  36. Nano Proteolysis Targeting Chimeras (PROTACs) with Anti‐Hook Effect for Tumor Therapy · Ni‐Yuan Zhang · 2023 · 106 citations · Cited by this paper
  37. Design of a PROTAC that antagonizes and destroys the cancer-forming X-protein of the hepatitis B virus · Kristopher Montrose · 2014 · 94 citations · Cited by this paper
  38. Targeted Degradation of the Aryl Hydrocarbon Receptor by the PROTAC Approach: A Useful Chemical Genetic Tool · Hyosung Lee · 2007 · 94 citations · Cited by this paper
  39. De Novo Design of an Androgen Receptor DNA Binding Domain‐Targeted peptide PROTAC for Prostate Cancer Therapy · Bohan Ma · 2022 · 89 citations · Cited by this paper

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