Research map: The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Back to the article

Papers in this map

  1. The Microbiota-Gut-Brain Axis · John F. Cryan · 2019 · 5234 citations · Cited by this paper
  2. ILAE ‐ YES global webinar series: Integrating clinical and basic science in epilepsy research · 2026 · Related
  3. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve · Javier A. Bravo · 2011 · 3894 citations · Cited by this paper
  4. KCNQ2 neonatal epilepsy: Impact of prompt diagnosis and treatment, and early predictors of outcome severity · 2026 · Related
  5. The role of inflammation in epilepsy · Annamaria Vezzani · 2010 · 1891 citations · Cited by this paper
  6. Trends in antiseizure medication monotherapy for pediatric epilepsy in the United States · 2026 · Related
  7. The Central Nervous System and the Gut Microbiome · Gil Sharon · 2016 · 1569 citations · Cited by this paper
  8. Cumulative electroconvulsive therapy sessions and focal epilepsy: A nationwide cohort study in Japan · 2026 · Related
  9. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs · Zhibin ZC Chen · 2017 · 1565 citations · Cited by this paper
  10. Incidence and outcomes of childhood status epilepticus in Kano, northern Nigeria · 2026 · Related
  11. Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant · Zachariah Michael DeFilipp · 2019 · 1255 citations · Cited by this paper
  12. Epilepsia open —April 2026 announcements · 2026 · Related
  13. Chemical transformation of xenobiotics by the human gut microbiota · Nitzan Koppel · 2017 · 1104 citations · Cited by this paper
  14. The Global Epilepsy Needs Study ( GENS ): A mixed‐methods, multi‐country exploration of the unmet psychosocial and everyday needs of people with epilepsy · 2026 · Related
  15. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet · C. Anders Olson · 2018 · 1094 citations · Cited by this paper
  16. Changes in effectiveness and safety in patients with Lennox–Gastaut syndrome transitioning from the fenfluramine randomized controlled trial to open‐label extension study · 2026 · Related
  17. Epilepsy · Orrin Devinsky · 2018 · 978 citations · Cited by this paper
  18. Computational protein stability analysis of SCN1A missense variants reveals domain‐dependent stability patterns · 2026 · Related
  19. Gut microbiome interactions with drug metabolism, efficacy, and toxicity · Ian D. Wilson · 2016 · 665 citations · Cited by this paper
  20. Artificial intelligence in the assessment of epilepsy‐related genetic mutations: Learned from GABA A receptors and GABA transporter 1 · 2026 · Related
  21. The gastrointestinal microbiota as a site for the biotransformation of drugs · Tiago Sousa · 2008 · 619 citations · Cited by this paper
  22. Drug-Resistant Epilepsy: Multiple Hypotheses, Few Answers · Fei Tang · 2017 · 496 citations · Cited by this paper
  23. Personalized Mapping of Drug Metabolism by the Human Gut Microbiome · Bahar Javdan · 2020 · 496 citations · Cited by this paper
  24. Several major antiepileptic drugs are substrates for human P-glycoprotein · Carlos Luna‐Tortós · 2008 · 309 citations · Cited by this paper
  25. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy · Gan Xie · 2017 · 299 citations · Cited by this paper
  26. Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet · Yunjian Zhang · 2018 · 272 citations · Cited by this paper
  27. Altered composition of the gut microbiome in patients with drug-resistant epilepsy · Anjiao Peng · 2018 · 244 citations · Cited by this paper
  28. Glucuronides in the gut: Sugar-driven symbioses between microbe and host · Samuel J. Pellock · 2017 · 231 citations · Cited by this paper
  29. Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report · Zhiqing He · 2017 · 226 citations · Cited by this paper
  30. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA‐B Genotypes and Phenytoin Dosing: 2020 Update · Jason H. Karnes · 2020 · 181 citations · Cited by this paper
  31. Microbiota–Gut–Brain Axis and Epilepsy: A Review on Mechanisms and Potential Therapeutics · Manqiu Ding · 2021 · 167 citations · Cited by this paper
  32. Drug-resistant epilepsy: Definition, pathophysiology, and management · Boulenouar Mesraoua · 2023 · 116 citations · Cited by this paper
  33. Alteration of Gut Microbiota in Patients With Epilepsy and the Potential Index as a Biomarker · Xue Gong · 2020 · 113 citations · Cited by this paper
  34. Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome · Jesús‐Servando Medel‐Matus · 2018 · 107 citations · Cited by this paper
  35. The gut microbiome in epilepsy · Birol Şafak · 2019 · 107 citations · Cited by this paper
  36. Variation in glucuronidation of lamotrigine in human liver microsomes · Upendra A. Argikar · 2009 · 79 citations · Cited by this paper
  37. First evidence of altered microbiota and intestinal damage and their link to absence epilepsy in a genetic animal model, the WAG/Rij rat · Rita Citraro · 2021 · 79 citations · Cited by this paper
  38. Cross talk between drug‐resistant epilepsy and the gut microbiome · Manisha Holmes · 2020 · 77 citations · Cited by this paper
  39. Gut Bacterial Dysbiosis in Children with Intractable Epilepsy · Kihyun Lee · 2020 · 72 citations · Cited by this paper

Source: OpenAlex (CC0)