Research map: Lung organoids as emerging models in idiopathic pulmonary fibrosis research: Current applications, challenges, and future directions

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Papers in this map

  1. Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis · Luca Richeldi · 2014 · 4742 citations · Cited by this paper
  2. Advances in orphan drug development for alpha-1 antitrypsin deficiency: a 2025 update from the FDA and EMA · 2026 · Related
  3. A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis · Talmadge E. King · 2014 · 4057 citations · Cited by this paper
  4. Assessment of efficacy and tolerability of elexacaftor-tezacaftor-ivacaftor in an observational cohort study of “aged” people with cystic fibrosis · 2026 · Related
  5. Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline · Ganesh Raghu · 2022 · 2852 citations · Cited by this paper
  6. The effectiveness of the AI-based RehabLung mobile rehabilitation system on cardiopulmonary function and user satisfaction in lung cancer patients undergoing thoracic surgery: a protocol for a two-arm randomized clinical trial · 2026 · Related
  7. Prednisone, Azathioprine, and N -Acetylcysteine for Pulmonary Fibrosis · The Idiopathic Pulmonary Fibrosis Clinical Research Network · 2012 · 1627 citations · Cited by this paper
  8. Spontaneous pneumothorax-associated with genetic disorders · 2026 · Related
  9. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis · Fei Liu · 2014 · 874 citations · Cited by this paper
  10. Randomized, phase I studies to evaluate the safety, tolerability, and pharmacokinetics of an inhaled, TMEM16A potentiator, GDC-6988, in healthy subjects · 2025 · Related
  11. In vitro generation of human pluripotent stem cell derived lung organoids · Briana R. Dye · 2015 · 845 citations · Cited by this paper
  12. Effects of dual bronchodilation on right ventricular function and troponin-I in newly diagnosed, moderate-to-severe chronic obstructive pulmonary disease: a prospective real-world observational study · 2026 · Related
  13. Extracellular matrix hydrogels from decellularized tissues: Structure and function · Lindsey T. Saldin · 2016 · 833 citations · Cited by this paper
  14. Bioequivalence of budesonide/glycopyrrolate/formoterol fumarate with a next-generation propellant versus hydrofluoroalkane-134a in healthy adults: phase I, randomized, double-blind, single-dose, partial-replicate, three-way cross-over lung exposure and total systemic exposure studies · 2026 · Related
  15. Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation · Adam J. Booth · 2012 · 700 citations · Cited by this paper
  16. Social risk factors in patients with cystic fibrosis: impacts on exacerbations, lung function, and BMI · 2025 · Related
  17. Generation of lung organoids from human pluripotent stem cells in vitro · Alyssa J. Miller · 2019 · 431 citations · Cited by this paper
  18. Tislelizumab in conjunction with chemotherapy for the treatment of nasal metastasis from lung squamous cell carcinoma: a case report and literature review · 2025 · Related
  19. Towards organoid culture without Matrigel · Mark T. Kozlowski · 2021 · 406 citations · Cited by this paper
  20. Pulmonary tuberculosis during the developmental period contributes to COPD and pre-COPD in mid-to-late adulthood: a retrospective cohort study · 2026 · Related
  21. Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis · Tanyalak Parimon · 2020 · 389 citations · Cited by this paper
  22. Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis · Qianru Mei · 2022 · 367 citations · Cited by this paper
  23. Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis · Jun Tashiro · 2017 · 331 citations · Cited by this paper
  24. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells · Jaymin J. Kathiriya · 2021 · 281 citations · Cited by this paper
  25. The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis · Moisés Selman · 2019 · 238 citations · Cited by this paper
  26. Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis · Francesco Bonella · 2023 · 180 citations · Cited by this paper
  27. Engineered cell and tissue models of pulmonary fibrosis · Aswin Sundarakrishnan · 2017 · 153 citations · Cited by this paper
  28. Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19 · Courtney Tindle · 2021 · 141 citations · Cited by this paper
  29. Pirfenidone and Nintedanib in Pulmonary Fibrosis: Lights and Shadows · Maria I. Chianese · 2024 · 101 citations · Cited by this paper
  30. Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro · Cassandra L. Petrou · 2020 · 99 citations · Cited by this paper
  31. Bioreactor Technologies for Enhanced Organoid Culture · Joseph P. Licata · 2023 · 97 citations · Cited by this paper
  32. Bioengineered 3D Models to Recapitulate Tissue Fibrosis · Marta Sacchi · 2020 · 95 citations · Cited by this paper
  33. Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids · Takahiro Suezawa · 2021 · 91 citations · Cited by this paper
  34. Human pluripotent stem cell-derived alveolar organoids for modeling pulmonary fibrosis and drug testing · Jung‐Hyun Kim · 2021 · 83 citations · Cited by this paper
  35. Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids · Yifei Miao · 2025 · 82 citations · Cited by this paper
  36. Cellular Senescence in Lung Fibrosis · Fernanda Hernández‐González · 2021 · 75 citations · Cited by this paper
  37. Generation of Complete Multi−Cell Type Lung Organoids From Human Embryonic and Patient‐Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation · Sandra Lawrynowicz Leibel · 2020 · 72 citations · Cited by this paper
  38. Strategies for genetic manipulation of adult stem cell-derived organoids · Constantin Menche · 2021 · 72 citations · Cited by this paper
  39. Early Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis: A Narrative Review · H Alsomali · 2023 · 71 citations · Cited by this paper

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