Research map: Epigenetic Reprogramming in Cancer Metastasis: From Histone Modifications to Therapeutic Vulnerabilities

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Papers in this map

  1. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis · Rajnish A. Gupta · 2010 · 5343 citations · Cited by this paper
  2. The Male Predominance in HBV-Related Hepatocellular Carcinoma: Unraveling the Axis of Androgen Receptor, Viral Replication, and Immune Evasion via NKG2D Ligands · 2026 · Related
  3. Targeting EZH2 in cancer · Kimberly Hyunjung Kim · 2016 · 1483 citations · Cited by this paper
  4. Hub Gene Clusters Reveal Dysregulated Synaptic Neurotransmitter Signaling Pathways and Drug Repurposing Prospect in Brain Tumors · 2026 · Related
  5. EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation · Wendy Béguelin · 2013 · 869 citations · Cited by this paper
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  7. Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex · Héctor Peinado · 2003 · 762 citations · Cited by this paper
  8. Molecular Insight and Antioxidative Therapeutic Potentials of Plant-Derived Compounds in Breast Cancer Treatment · 2025 · Related
  9. LSD1/KDM1A inhibitors in clinical trials: advances and prospects · Yuan Fang · 2019 · 461 citations · Cited by this paper
  10. Advancing Immunotherapy in Cervical Cancer: Biological Rationale, Clinical Evidence, and Biomarker Standardization · 2026 · Related
  11. BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression · Hengrui Zhu · 2016 · 442 citations · Cited by this paper
  12. Cancer Therapy-Related Cutaneous Toxicities: Prognostic Biomarkers, Immunologic Endotypes, and Novel Therapeutic Strategies · 2026 · Related
  13. The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine‐specific demethylase 1 · Yiwei Lin · 2010 · 377 citations · Cited by this paper
  14. Transformation of NSCLC to SCLC: Insights into Molecular Alterations, Tumor Origin, and Therapeutic Advancements · 2026 · Related
  15. The PEMDAC phase 2 study of pembrolizumab and entinostat in patients with metastatic uveal melanoma · Lars Ny · 2021 · 185 citations · Cited by this paper
  16. Obesity as a Whole-Body Regulatory Disorder: A Systems Biology Framework for Metaflammation, Accelerated Aging, and Colorectal Cancer Risk · 2026 · Related
  17. Recent histone deacetylase inhibitors in cancer therapy · Roza Parveen · 2023 · 162 citations · Cited by this paper
  18. Melanotransferrin as a Potential Target for the Selective Killing of Melanoma and Triple-Negative Breast Cancer Cells In Vitro Using Novel SNAP-Tag-Based Antibody–AURIF Conjugate · 2025 · Related
  19. KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming · Feifei Na · 2022 · 127 citations · Cited by this paper
  20. Precision Medicine for Older AML Patients · 2025 · Related
  21. BET protein inhibitor JQ1 downregulates chromatin accessibility and suppresses metastasis of gastric cancer via inactivating RUNX2/NID1 signaling · Siqi Zhou · 2020 · 106 citations · Cited by this paper
  22. Epigenetic regulation in cancer · Minzhi Gu · 2024 · 106 citations · Cited by this paper
  23. “Dangling” Accelerated Approvals in Oncology · Julia A. Beaver · 2021 · 99 citations · Cited by this paper
  24. Circulating tumor DNA methylation detection as biomarker and its application in tumor liquid biopsy: advances and challenges · Lingyu Li · 2024 · 95 citations · Cited by this paper
  25. STAT3 Signaling in Breast Cancer: Multicellular Actions and Therapeutic Potential · Sarah Q. To · 2022 · 88 citations · Cited by this paper
  26. BET proteins: Biological functions and therapeutic interventions · Jiawei Guo · 2023 · 80 citations · Cited by this paper
  27. Epithelial-mesenchymal transition · Cecilia Xi Zhang · 2025 · 77 citations · Cited by this paper
  28. EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers · Sandy Leung–Kuen Au · 2013 · 69 citations · Cited by this paper
  29. Entinostat, a class I selective histone deacetylase inhibitor, plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer: A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial · Binghe Xu · 2023 · 63 citations · Cited by this paper
  30. The LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes · Elisabet Cuyàs · 2020 · 59 citations · Cited by this paper
  31. Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial · Marina Baretti · 2024 · 50 citations · Cited by this paper
  32. HOTAIR in cancer: diagnostic, prognostic, and therapeutic perspectives · Majid Nazari · 2024 · 45 citations · Cited by this paper
  33. Enhancer reprogramming: critical roles in cancer and promising therapeutic strategies · Jinshou Yang · 2025 · 45 citations · Cited by this paper
  34. Crosstalk between macrophage-derived PGE 2 and tumor UHRF1 drives hepatocellular carcinoma progression · Jian Zhang · 2022 · 43 citations · Cited by this paper
  35. Engineered nanomaterials as an effective tool for HER2+ breast cancer therapy · Prashant Kumar Pandey · 2022 · 41 citations · Cited by this paper
  36. DNA methylation and gene expression as determinants of genome-wide cell-free DNA fragmentation · Michaël Noë · 2024 · 41 citations · Cited by this paper
  37. Revisiting 3D chromatin architecture in cancer development and progression · Yuliang Feng · 2020 · 40 citations · Cited by this paper
  38. MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells · Dan Sun · 2022 · 35 citations · Cited by this paper
  39. αvβ3 Integrin and Folate-Targeted pH-Sensitive Liposomes with Dual Ligand Modification for Metastatic Breast Cancer Treatment · Prashant Kumar Pandey · 2024 · 35 citations · Cited by this paper

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