Research map: Interleukin‐18 Constrains the Intestinal Tuft Cell‐Driven Responses During Helminth Infection

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  1. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity · Daniel R. Neill · 2010 · 2092 citations · Cited by this paper
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  5. Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit · Jakob von Moltke · 2015 · 1264 citations · Cited by this paper
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  9. The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis · Hasan Zaki · 2010 · 992 citations · Cited by this paper
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  11. Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites · François Gerbe · 2016 · 989 citations · Cited by this paper
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  13. Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis · Christoph S. N. Klose · 2016 · 965 citations · Cited by this paper
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  15. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut · Michael R. Howitt · 2016 · 962 citations · Cited by this paper
  16. Dual Functions of Treg in the Mucosal Barrier and Lung Cancer Microenvironment and Prospects for Targeted Therapy · 2026 · Related
  17. MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion · Christopher J. Oliphant · 2014 · 699 citations · Cited by this paper
  18. Epidermal Dominance of Metabolically Constrained Immune Niches Underpins Immune Activation Signatures and Clinical Severity in Psoriatic Disease · 2026 · Related
  19. TH2 cell development and function · Jennifer A. Walker · 2017 · 675 citations · Cited by this paper
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  21. Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit · Marija S. Nadjsombati · 2018 · 584 citations · Cited by this paper
  22. Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis · Roni Nowarski · 2015 · 578 citations · Cited by this paper
  23. A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling · Christoph Schneider · 2018 · 503 citations · Cited by this paper
  24. IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice · Dong Li · 2014 · 416 citations · Cited by this paper
  25. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells · Tomohiro Yoshimoto · 1997 · 383 citations · Cited by this paper
  26. Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine · Weiwei Lei · 2018 · 285 citations · Cited by this paper
  27. Unique Action of Interleukin-18 on T Cells and Other Immune Cells · Kenji Nakanishi · 2018 · 268 citations · Cited by this paper
  28. Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine · Zhen Xiong · 2022 · 112 citations · Cited by this paper
  29. Interleukin (Il)-18 Promotes the Development of Chronic Gastrointestinal Helminth Infection by Downregulating IL-13 · Helena Helmby · 2001 · 105 citations · Cited by this paper
  30. BMP signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13–driven tuft cell hyperplasia · Håvard T. Lindholm · 2022 · 71 citations · Cited by this paper
  31. The ins and outs of innate and adaptive type 2 immunity · Ari B. Molofsky · 2023 · 71 citations · Cited by this paper
  32. The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection · Rafid Al-Hallaf · 2018 · 60 citations · Cited by this paper

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