Research map: Relationship between Metabolic Remodeling of Pancreatic β-cells and Pancreatic Histology in Type 2 Diabetes

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Papers in this map

  1. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation · Matthew G. Vander Heiden · 2009 · 16528 citations · Cited by this paper
  2. Targeting PFKFB3 Metabolic Gatekeeping of β-Cell Dysfunctional States Enables Durable Glucose Tolerance in Type 2 Diabetes · Kavit Raval · 2026 · Cites this paper
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  12. Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients · Hiroyasu Sakuraba · 2002 · 687 citations · Cited by this paper
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  14. Hypoxia-inducible Factor-1-mediated Expression of the 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) Gene · О. H. Minchenko · 2002 · 369 citations · Cited by this paper
  15. Is the diagnosis of Cushing disease moving beyond bilateral inferior petrosal sinus sampling? · 2026 · Related
  16. 6-Phosphofructo-2-kinase (pfkfb3) Gene Promoter Contains Hypoxia-inducible Factor-1 Binding Sites Necessary for Transactivation in Response to Hypoxia · Mercè Obach · 2004 · 285 citations · Cited by this paper
  17. Prospective evaluation of the effect of stopping estrogen-containing contraceptives on serum CBG and cortisol levels · 2026 · Related
  18. β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes · Yoshifumi Saisho · 2015 · 266 citations · Cited by this paper
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  22. Chronic pancreatitis, pseudotumors and other tumor-like lesions · Günter Klöppel · 2007 · 183 citations · Cited by this paper
  23. TGF ‐β1 targets Smad, p38 MAPK , and PI 3K/Akt signaling pathways to induce PFKFB 3 gene expression and glycolysis in glioblastoma cells · Ana Rodríguez‐García · 2017 · 179 citations · Cited by this paper
  24. Involvement of Oxidative Stress–Induced DNA Damage, Endoplasmic Reticulum Stress, and Autophagy Deficits in the Decline of β-Cell Mass in Japanese Type 2 Diabetic Patients · Hiroki Mizukami · 2014 · 111 citations · Cited by this paper
  25. Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients · Kosuke Kamata · 2014 · 100 citations · Cited by this paper
  26. The potential utility of PFKFB3 as a therapeutic target · Ramón Bartrons · 2018 · 92 citations · Cited by this paper
  27. IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function · Chiara Montemurro · 2019 · 90 citations · Cited by this paper
  28. Differences in the Degree of Cerulein-Induced Chronic Pancreatitis in C57BL/6 Mouse Substrains Lead to New Insights in Identification of Potential Risk Factors in the Development of Chronic Pancreatitis · Barbara Ulmasov · 2013 · 72 citations · Cited by this paper
  29. Activation of the HIF1α/PFKFB3 stress response pathway in beta cells in type 1 diabetes · Hiroshi Nomoto · 2019 · 70 citations · Cited by this paper
  30. An Update on the Effect of Incretin-Based Therapies on β-Cell Function and Mass · Suk Chon · 2016 · 58 citations · Cited by this paper
  31. Age‐associated changes of islet endocrine cells and the effects of body mass index in J apanese · Hiroki Mizukami · 2013 · 54 citations · Cited by this paper
  32. Hyperglycemia and hyperinsulinemia have additive effects on activation and proliferation of pancreatic stellate cells: Possible explanation of islet‐specific fibrosis in type 2 diabetes mellitus · Oak‐Kee Hong · 2007 · 49 citations · Cited by this paper
  33. Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction · Mayumi Sasaki · 2013 · 42 citations · Cited by this paper
  34. The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror · María Sofía Martínez · 2021 · 35 citations · Cited by this paper
  35. Pancreas Atrophy and Islet Amyloid Deposition in Patients With Elderly-Onset Type 2 Diabetes · Xin An · 2017 · 31 citations · Cited by this paper
  36. Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors · Reinier Alvarez · 2021 · 24 citations · Cited by this paper
  37. Advances in the understanding of the role and mechanism of action of PFKFB3‑mediated glycolysis in liver fibrosis (Review) · Qian Liu · 2024 · 20 citations · Cited by this paper
  38. TGF ‐β signalling prevents pancreatic beta cell death after proliferation · Lei Chen · 2015 · 11 citations · Cited by this paper
  39. Intercellular Communication in the Islet of Langerhans in Health and Disease · Xue Wen Ng · 2021 · 9 citations · Cited by this paper

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