Research map: Notoginsenoside R1 alleviates cholestatic liver fibrosis through modulation of the intestinal FXR-FGF15 axis and bile acid homeostasis

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  1. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis · Takeshi Inagaki · 2005 · 1860 citations · Cited by this paper
  2. Genetic polymorphisms of drug-metabolizing cytochromes P450 and flavin-containing monooxygenases in dogs and pigs inform the prediction of drug metabolism and toxicity in humans and other animal species · Yasuhiro Uno · 2026 · Related
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  13. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice · Phillipp Hartmann · 2017 · 288 citations · Cited by this paper
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  15. Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis · Salvatore Modica · 2011 · 271 citations · Cited by this paper
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  17. The microbiome modulating activity of bile acids · Yuan Tian · 2020 · 261 citations · Cited by this paper
  18. Glycoprotein nonmetastatic B as a pharmacological target in cancer: structural mechanisms, druggability, and therapeutic translation · 2026 · Related
  19. New aspects of hepatic fibrosis · David A. Brenner · 2000 · 202 citations · Cited by this paper
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  21. Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia · Hongtao Xu · 2023 · 190 citations · Cited by this paper
  22. Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes · Bingting Chen · 2023 · 140 citations · Cited by this paper
  23. Metabolic Messengers: fibroblast growth factor 15/19 · Raffaella Maria Gadaleta · 2019 · 137 citations · Cited by this paper
  24. Deoxycholic Acid-Induced Gut Dysbiosis Disrupts Bile Acid Enterohepatic Circulation and Promotes Intestinal Inflammation · Mengque Xu · 2020 · 120 citations · Cited by this paper
  25. FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis · Suyuan Ji · 2019 · 115 citations · Cited by this paper
  26. FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid · Kang Wang · 2023 · 115 citations · Cited by this paper
  27. The gut microbiome-bile acid axis in hepatocarcinogenesis · Liwei Wu · 2020 · 108 citations · Cited by this paper
  28. An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis · Yifeng Wang · 2020 · 100 citations · Cited by this paper
  29. Bile acid metabolism dysregulation associates with cancer cachexia: roles of liver and gut microbiome · Li‐Xing Feng · 2021 · 96 citations · Cited by this paper
  30. Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression · Bin Zhang · 2019 · 95 citations · Cited by this paper
  31. Sestrin2 protects against cholestatic liver injury by inhibiting endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis · Daewon Han · 2022 · 95 citations · Cited by this paper
  32. Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation · Honghong Liu · 2020 · 87 citations · Cited by this paper
  33. The relationship between fecal bile acids and microbiome community structure in pediatric Crohn’s disease · Jessica Connors · 2019 · 82 citations · Cited by this paper
  34. Bile Acid Uptake Transporters as Targets for Therapy · Davor Slijepcevic · 2017 · 80 citations · Cited by this paper
  35. Developments in bile salt based therapies: A critical overview · Joanne M. Donkers · 2018 · 79 citations · Cited by this paper
  36. Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota · Hideki Mori · 2022 · 75 citations · Cited by this paper
  37. Attenuation of bile acid-mediated FXR and PXR activation in patients with Crohn’s disease · Aze Suzanne Wilson · 2020 · 74 citations · Cited by this paper
  38. Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2 · Hao Chen · 2015 · 71 citations · Cited by this paper
  39. Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis) · Chunlei Wei · 2022 · 71 citations · Cited by this paper

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