Research map: Protecting the Aging Brain in Diabetes: Mechanism, Biomarkers, and Emerging Therapeutic Frontiers in Cognitive Impairment—A Comprehensive Review

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  1. The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment · Ziad Samir Nasreddine · 2005 · 26262 citations · Cited by this paper
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  5. Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications · Geert Jan Biessels · 2018 · 1475 citations · Cited by this paper
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  7. Glucose Levels and Risk of Dementia · Paul K. Crane · 2013 · 931 citations · Cited by this paper
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  9. Dementia and Alzheimer Disease Incidence · Walter A. Kukull · 2002 · 815 citations · Cited by this paper
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  11. Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia · Saion Chatterjee · 2015 · 732 citations · Cited by this paper
  12. Growing Heart Valves in Congenital Cardiac Surgery: Mechanisms and Considerations for Tissue-Engineered Heart Valves, Noncryopreserved Homografts, and Partial Heart Transplantation · 2026 · Related
  13. Diabetes and Cognitive Impairment · Lindsay A. Zilliox · 2016 · 545 citations · Cited by this paper
  14. Impella Outcomes in Acute Myocardial Infarction Versus Non–Acute Myocardial Infarction Cardiogenic Shock: A United States Nationwide Propensity-Matched Analysis (2016–2022) · 2026 · Related
  15. Relationship Between Baseline Glycemic Control and Cognitive Function in Individuals With Type 2 Diabetes and Other Cardiovascular Risk Factors · Tali Cukierman‐Yaffe · 2009 · 453 citations · Cited by this paper
  16. Chocolate and Cardiovascular Disease · 2026 · Related
  17. Engineered human blood–brain barrier microfluidic model for vascular permeability analyses · Cynthia Hajal · 2022 · 264 citations · Cited by this paper
  18. Pulmonary Hypertension and Kidney Disease: A Review of a High-Risk Patient Population · 2026 · Related
  19. Vascular inflammation in cerebral small vessel disease · Rob P.W. Rouhl · 2011 · 221 citations · Cited by this paper
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  21. Hypoglycemic Neuronal Death and Cognitive Impairment Are Prevented by Poly(ADP-Ribose) Polymerase Inhibitors Administered after Hypoglycemia · Sang Won Suh · 2003 · 210 citations · Cited by this paper
  22. Type 2 Diabetes and Cognitive Impairment: Linking Mechanisms · Jose Alejandro Luchsinger · 2012 · 199 citations · Cited by this paper
  23. Effectiveness and Safety of Dementia Care Management in Primary Care · Jochen René Thyrian · 2017 · 198 citations · Cited by this paper
  24. Effectiveness of Diabetes Self-Management Education (Dsme) in Type 2 Diabetes Mellitus (T2Dm) Patients: Systematic Literature Review · Ucik Ernawati · 2021 · 192 citations · Cited by this paper
  25. Glial influences on BBB functions and molecular players in immune cell trafficking · Marc‐André Lécuyer · 2015 · 167 citations · Cited by this paper
  26. The relationship between cognitive impairment and diabetes self-management in a population-based community sample of older adults with Type 2 diabetes · Denise G. Feil · 2011 · 163 citations · Cited by this paper
  27. Type 2 Diabetes and Cognitive Decline in Middle-Aged Men and Women · Astrid C. J. Nooyens · 2010 · 147 citations · Cited by this paper
  28. Diabetes, markers of brain pathology and cognitive function · Chengxuan Qiu · 2013 · 134 citations · Cited by this paper
  29. Diabetes and cognitive function: An evidence-based current perspective · Meghna Julian Sebastian · 2023 · 106 citations · Cited by this paper
  30. Mitochondrial Dysfunction, Oxidative Stress, and Inter-Organ Miscommunications in T2D Progression · Rajakrishnan Veluthakal · 2024 · 84 citations · Cited by this paper
  31. The impact of diabetes in cognitive impairment: A review of current evidence and prospects for future investigations · Nicholas Aderinto · 2023 · 83 citations · Cited by this paper
  32. Metformin in elderly type 2 diabetes mellitus: dose-dependent dementia risk reduction · Mingyang Sun · 2023 · 64 citations · Cited by this paper
  33. Liraglutide in mild to moderate Alzheimer’s disease: a phase 2b clinical trial · Paul Edison · 2025 · 58 citations · Cited by this paper
  34. Biomarkers of blood–brain barrier and neurovascular unit integrity in human cognitive impairment and dementia · Scott R. French · 2025 · 41 citations · Cited by this paper
  35. Dementia risk in patients with type 2 diabetes: Comparing metformin with no pharmacological treatment · Bang Zheng · 2023 · 33 citations · Cited by this paper
  36. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research’s Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health’s National Institute of Diabetes and Digestive and Kidney Diseases · William T. Cefalu · 2021 · 32 citations · Cited by this paper
  37. Cognitive functioning in patients with classical galactosemia: a systematic review · Merel E. Hermans · 2019 · 28 citations · Cited by this paper
  38. Memory and processing speed impairments in first-episode drug-naïve patients with major depressive disorder · Yongbo Hu · 2022 · 22 citations · Cited by this paper
  39. Real‐world observations of GLP‐1 receptor agonists and SGLT‐2 inhibitors as potential treatments for Alzheimer's disease · Pengyue Zhang · 2025 · 21 citations · Cited by this paper

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