Research map: Beyond Trough Levels: Tacrolimus Dose Requirements and Individualized Monitoring in Kidney Transplantation

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Papers in this map

  1. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing · Kelly A. Birdwell · 2015 · 742 citations · Cited by this paper
  2. Comment on “A comparative study of once-daily versus twice-daily tacrolimus in deceased donor kidney transplant recipients: a national cohort analysis” · Stefan Reuter · 2026 · Cites this paper
  3. Outside Front Cover · 2026 · Related
  4. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report · Mercè Brunet · 2019 · 712 citations · Cited by this paper
  5. Opportunistic Central Nervous System Infections and Graft Outcomes in Solid Organ Transplant Recipients · 2026 · Related
  6. The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation · Dennis Alexander Hesselink · 2013 · 236 citations · Cited by this paper
  7. Imaging Mass Cytometry Revealed Spatial Immune Diversity in Ischemia Reperfusion Injuries · 2026 · Related
  8. Tacrolimus Pharmacogenetics: The CYP3A5*1 Allele Predicts Low Dose-Normalized Tacrolimus Blood Concentrations in Whites and South Asians · Iain A. M. MacPhee · 2005 · 207 citations · Cited by this paper
  9. HLA-E-Restricted CD8 Tregs Represent a Promising Cell-Based Therapy Surpassing CD4 Tregs and CAR-Tregs Achieving Superior Allograft Survival · 2026 · Related
  10. A Steady-State Head-to-Head Pharmacokinetic Comparison of All FK-506 (Tacrolimus) Formulations (ASTCOFF): An Open-Label, Prospective, Randomized, Two-Arm, Three-Period Crossover Study · Simon Tremblay · 2016 · 173 citations · Cited by this paper
  11. CMV Immune Dynamics Post Lung Transplantation · 2026 · Related
  12. Exploring the Complexity of Death-Censored Kidney Allograft Failure · Manuel Mayrdorfer · 2021 · 167 citations · Cited by this paper
  13. Social Support Facilitates Liver Transplant and Living Liver Donor Evaluation: A Qualitative Study · 2026 · Related
  14. Tacrolimus Predose Concentrations Do Not Predict the Risk of Acute Rejection After Renal Transplantation: A Pooled Analysis From Three Randomized-Controlled Clinical Trials · Rachida Bouamar · 2013 · 160 citations · Cited by this paper
  15. High-Pressure Gaseous Oxygen-Xenon Perfusion Enables Scale-Independent Heart Preservation: A Porcine Model Study · 2026 · Related
  16. A high intrapatient variability in tacrolimus exposure is associated with poor long-term outcome of kidney transplantation · Nauras Shuker · 2016 · 153 citations · Cited by this paper
  17. Comprehensive Novel Kidney Transplant Risk Calculator Tool to Predict Post-Transplant Outcome · 2026 · Related
  18. Importance of hematocrit for a tacrolimus target concentration strategy · Elisabet Størset · 2013 · 141 citations · Cited by this paper
  19. Microvascular Inflammation (MVI) in the Crosshairs: Do Allo- or Autoantibodies Shape Kidney Allograft Pathology? · 2026 · Related
  20. Tacrolimus Dose Requirements and CYP3A5 Genotype and the Development of Calcineurin Inhibitor-Associated Nephrotoxicity in Renal Allograft Recipients · Dirk R. J. Kuypers · 2010 · 120 citations · Cited by this paper
  21. Human lymphoid organoids as a platform for interrogating adaptive immunity, tolerance, and alloimmunity · 2026 · Related
  22. Time-Related Clinical Determinants of Long-Term Tacrolimus Pharmacokinetics in Combination Therapy with Mycophenolic Acid and Corticosteroids · Dirk R. J. Kuypers · 2004 · 118 citations · Cited by this paper
  23. The Tacrolimus Metabolism Rate Influences Renal Function after Kidney Transplantation · Gerold Thölking · 2014 · 110 citations · Cited by this paper
  24. Novel Once-Daily Extended-Release Tacrolimus Versus Twice-Daily Tacrolimus in De Novo Kidney Transplant Recipients: Two-Year Results of Phase 3, Double-Blind, Randomized Trial · Lionel P. E. Rostaing · 2015 · 105 citations · Cited by this paper
  25. Results of ASERTAA, a Randomized Prospective Crossover Pharmacogenetic Study of Immediate-Release Versus Extended-Release Tacrolimus in African American Kidney Transplant Recipients · Jennifer Trofe‐Clark · 2017 · 93 citations · Cited by this paper
  26. Lessons From Routine Dose Adjustment of Tacrolimus in Renal Transplant Patients Based on Global Exposure · Franck Saint‐Marcoux · 2013 · 77 citations · Cited by this paper
  27. The TOMATO Study (Tacrolimus Metabolization in Kidney Transplantation): Impact of the Concentration–Dose Ratio on Death-censored Graft Survival · Thomas Jouvé · 2019 · 74 citations · Cited by this paper
  28. Tacrolimus troughs and genetic determinants of metabolism in kidney transplant recipients: A comparison of four ancestry groups · Moataz E. Mohamed · 2019 · 60 citations · Cited by this paper
  29. High Tacrolimus Clearance Is a Risk Factor for Acute Rejection in the Early Phase After Renal Transplantation · Erlend Johannessen Egeland · 2017 · 51 citations · Cited by this paper
  30. Influence of tacrolimus metabolism rate on BKV infection after kidney transplantation · Gerold Thölking · 2016 · 46 citations · Cited by this paper
  31. Tacrolimus Concentration‐to‐Dose Ratios in Kidney Transplant Recipients and Relationship to Clinical Outcomes · Felicia Bartlett · 2019 · 29 citations · Cited by this paper
  32. A single centre in-depth analysis of death with a functioning kidney graft and reasons for overall graft failure · Manuel Mayrdorfer · 2022 · 27 citations · Cited by this paper
  33. Increased renal function decline in fast metabolizers using extended-release tacrolimus after kidney transplantation · Gerold Thölking · 2021 · 22 citations · Cited by this paper
  34. Can the Area Under the Curve/Trough Level Ratio Be Used to Optimize Tacrolimus Individual Dose Adjustment? · Jean‐Baptiste Woillard · 2022 · 18 citations · Cited by this paper
  35. A randomized crossover study comparing different tacrolimus formulations to reduce intrapatient variability in tacrolimus exposure in kidney transplant recipients · Kim L. W. Bunthof · 2021 · 17 citations · Cited by this paper
  36. Clinical Impact of the Adaptation of Initial Tacrolimus Dosing to the CYP3A5 Genotype After Kidney Transplantation: Systematic Review and Meta-Analysis of Randomized Controlled Trials · Hui Ling Yang · 2021 · 14 citations · Cited by this paper
  37. Effect of Concentration/Dose Ratio in De Novo Kidney Transplant Recipients Receiving LCP-Tacrolimus or Immediate-Release Tacrolimus: Post Hoc Analysis of a Phase 3 Clinical Trial · Barbara M. Suwelack · 2020 · 12 citations · Cited by this paper
  38. Determination of tacrolimus in human whole blood in kidney transplant recipients using a rapid and specific LC–MS/MS method · Trần Bá Hiếu · 2023 · 11 citations · Cited by this paper
  39. A Population Pharmacokinetic Model and Dosing Algorithm to Guide the Tacrolimus Starting and Follow-Up Dose in Living and Deceased Donor Kidney Transplant Recipients · Marith I. Francke · 2025 · 8 citations · Cited by this paper

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