Research map: Beyond motor fluctuations: Understanding the clinical correlates of OFF burden in Parkinson's disease

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  1. Likert scales, levels of measurement and the “laws” of statistics · Geoff R. Norman · 2010 · 4825 citations · Cited by this paper
  2. Celebrating the legacy of two decades of Parkinson's disease research in South Africa · 2026 · Related
  3. Validation of the questionnaire for impulsive‐compulsive disorders in Parkinson's disease · Daniel A. Weintraub · 2009 · 543 citations · Cited by this paper
  4. Practical approaches to inclusive recruitment practices in Parkinson's disease research · 2026 · Related
  5. Factors predictive of the development of Levodopa‐induced dyskinesia and wearing‐off in Parkinson's disease · C. Warren Olanow · 2013 · 486 citations · Cited by this paper
  6. Structural biology of alpha-synuclein amyloid filaments: Implications in synucleinopathies · 2026 · Related
  7. TIME ESTIMATION AND REPRODUCTION IS ABNORMAL IN PARKINSON'S DISEASE · María A. Pastor · 1992 · 386 citations · Cited by this paper
  8. Clinical GDNF delivery methods for Parkinson's disease · 2026 · Related
  9. Nonmotor fluctuations in Parkinson disease · Alexander Storch · 2013 · 373 citations · Cited by this paper
  10. Differential effects of levodopa on social cognition in people with Parkinson's disease · 2026 · Related
  11. The response to levodopa in parkinson's disease: Imposing pharmacological law and order · John G. Nutt · 1996 · 302 citations · Cited by this paper
  12. Greater burden of Alzheimer's Co-pathology in women with Parkinson's disease dementia · 2026 · Related
  13. Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations · Mariangela Pierantozzi · 2006 · 197 citations · Cited by this paper
  14. Parkinson's disease and the concept of resilience, cognitive, and motor reserve · 2026 · Related
  15. Dopamine dysregulation syndrome in Parkinson’s disease: a systematic review of published cases · Nicola Warren · 2017 · 174 citations · Cited by this paper
  16. Regulatory endorsement for the application of α-synuclein seed amplification assay as a susceptibility and risk biomarker for clinical trials targeting synucleinopathies · 2026 · Related
  17. The spectrum of “off” in Parkinson's disease: What have we learned over 40 years? · Kelvin L. Chou · 2018 · 170 citations · Cited by this paper
  18. Digital profiling of dysarthria in late- and early-onset Parkinson's disease · 2026 · Related
  19. Safety and efficacy of CVT-301 (levodopa inhalation powder) on motor function during off periods in patients with Parkinson's disease: a randomised, double-blind, placebo-controlled phase 3 trial · Peter A. LeWitt · 2019 · 130 citations · Cited by this paper
  20. Crowdsourcing and machine learning contests in Parkinson's disease research - when do they work? · 2026 · Related
  21. Effect of Long-term Therapy on the Pharmacodynamics of Levodopa · John G. Nutt · 1992 · 126 citations · Cited by this paper
  22. Neurobehavioral Mechanisms of Temporal Processing Deficits in Parkinson's Disease · Deborah Lynn Harrington · 2011 · 120 citations · Cited by this paper
  23. Influence of Meal Ingestion Time on Pharmacokinetics of Orally Administered Levodopa in Parkinsonian Patients · Agostino Baruzzi · 1987 · 91 citations · Cited by this paper
  24. Predictors of motor complications in early Parkinson's disease: A prospective cohort study · Mark John Kelly · 2019 · 78 citations · Cited by this paper
  25. Loss of long-duration response to levodopa over time in PD · Mario Zappia · 1999 · 66 citations · Cited by this paper
  26. Non‐motor symptom burden is strongly correlated to motor complications in patients with Parkinson’s disease · Diego Santos‐García · 2020 · 59 citations · Cited by this paper
  27. Literature review · Stewart Alan Factor · 2004 · 48 citations · Cited by this paper
  28. Impaired Self-Awareness of Motor Disturbances in Parkinson's Disease · Franziska Maier · 2017 · 41 citations · Cited by this paper
  29. Health-related quality of life in Parkinson’s: impact of ‘off’ time and stated treatment preferences · Cicely Kerr · 2015 · 30 citations · Cited by this paper
  30. Assessment of Wearing Off in Parkinson’s disease using objective measurement · Parisa Farzanehfar · 2020 · 28 citations · Cited by this paper
  31. On demand therapy for Parkinson’s disease patients: Opportunities and choices · Robert A. Hauser · 2021 · 28 citations · Cited by this paper
  32. Longitudinal Change and Progression Indicators Using the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale in Two Independent Cohorts with Early Parkinson’s Disease · Michael Bartl · 2021 · 25 citations · Cited by this paper
  33. Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years · Sacha E. Gandhi · 2024 · 24 citations · Cited by this paper
  34. Timing and Kinetics of Nonmotor Fluctuations in Advanced Parkinson’s Disease · Christiana Ossig · 2017 · 23 citations · Cited by this paper
  35. Understanding, Impact, and Communication of “Off” Periods in Parkinson's Disease: A Scoping Review · Tara Rastgardani · 2018 · 23 citations · Cited by this paper
  36. The Most Bothersome Aspects of Off Periods Reported by Individuals with Parkinson's Disease · Lana M. Chahine · 2020 · 22 citations · Cited by this paper
  37. Time Distortion in Parkinsonism · Yasuo Terao · 2021 · 22 citations · Cited by this paper
  38. The Experience of OFF Periods in Parkinson’s Disease: Descriptions, Triggers, and Alleviating Factors · Sneha Shivkumar Mantri · 2021 · 21 citations · Cited by this paper
  39. Wearable sensor devices can automatically identify the ON-OFF status of patients with Parkinson's disease through an interpretable machine learning model · Xiaolong Wu · 2024 · 21 citations · Cited by this paper

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