Research map: Serial failure of the brain clearance continuum in Alzheimer’s disease: mechanisms and therapeutic perspectives

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Papers in this map

  1. The amyloid hypothesis of Alzheimer's disease at 25 years · Dennis J. Selkoe · 2016 · 6351 citations · Cited by this paper
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  17. Amyloid-β and Tau · George S. Bloom · 2014 · 2245 citations · Cited by this paper
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  19. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules · Aleksanteri Aspelund · 2015 · 2234 citations · Cited by this paper
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  21. Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease · Sandro Dá Mesquita · 2018 · 1486 citations · Cited by this paper
  22. Gamma frequency entrainment attenuates amyloid load and modifies microglia · Hannah F. Iaccarino · 2016 · 1380 citations · Cited by this paper
  23. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep · Nina E. Fultz · 2019 · 1243 citations · Cited by this paper
  24. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer’s disease cases · Toshiaki Taoka · 2017 · 1181 citations · Cited by this paper
  25. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension · Humberto Mestre · 2018 · 1176 citations · Cited by this paper
  26. Glymphatic failure as a final common pathway to dementia · Maiken Nedergaard · 2020 · 1159 citations · Cited by this paper
  27. Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid · Ji Hoon Ahn · 2019 · 829 citations · Cited by this paper
  28. Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model · Ian F. Harrison · 2020 · 673 citations · Cited by this paper
  29. Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia · Lauren M. Hablitz · 2019 · 643 citations · Cited by this paper
  30. Cerebrospinal Fluid Secretion by the Choroid Plexus · Helle Hasager Damkier · 2013 · 621 citations · Cited by this paper
  31. Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits · Zhiqiang Xu · 2015 · 514 citations · Cited by this paper
  32. Development and plasticity of meningeal lymphatic vessels · Salli Antila · 2017 · 491 citations · Cited by this paper
  33. Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier · Steffen E. Storck · 2015 · 487 citations · Cited by this paper
  34. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy · Sandro Dá Mesquita · 2021 · 438 citations · Cited by this paper
  35. Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics · Steven T. Proulx · 2021 · 423 citations · Cited by this paper
  36. Sleep deprivation impairs molecular clearance from the human brain · Per Kristian Eide · 2020 · 399 citations · Cited by this paper
  37. Diffusion Tensor Image Analysis ALong the Perivascular Space (DTI-ALPS): Revisiting the Meaning and Significance of the Method · Toshiaki Taoka · 2024 · 380 citations · Cited by this paper
  38. Choroid plexus and the blood–cerebrospinal fluid barrier in disease · Peter Solar · 2020 · 371 citations · Cited by this paper
  39. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis · Elisavet Fotiou · 2015 · 341 citations · Cited by this paper

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