Research map: The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation

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  1. Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene · I. Sadaf Farooqi · 2003 · 1813 citations · Cited by this paper
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  7. Melanocortin-4 receptor–regulated energy homeostasis · Michael J. Krashes · 2016 · 378 citations · Cited by this paper
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  9. Mutations in ligands and receptors of the leptin–melanocortin pathway that lead to obesity · I. Sadaf Farooqi · 2008 · 293 citations · Cited by this paper
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  11. Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms · Giles S.H. Yeo · 2003 · 237 citations · Cited by this paper
  12. MYO6 and Heart: A Novel Variant in a Deaf Infant With Supraventricular Tachycardia · 2026 · Related
  13. From obesity genetics to the future of personalized obesity therapy · Julia S. El-Sayed Moustafa · 2013 · 221 citations · Cited by this paper
  14. Single Nucleotide Polymorphism Microarray Analysis Unveils Copy‐Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia · 2026 · Related
  15. Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity · Frank Geller · 2004 · 218 citations · Cited by this paper
  16. X‐Linked Intellectual Developmental Disorder‐93 Caused by BRWD3 Mutation in Females: A Case Report and Literature Review · 2026 · Related
  17. Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment · Peter Kühnen · 2019 · 205 citations · Cited by this paper
  18. Identification of the MYH6 c. 804G >C Synonymous Variant Causing Exon Skipping in a Hypertrophic Cardiomyopathy Family · 2026 · Related
  19. Molecular Determinants of Ligand Binding to the Human Melanocortin-4 Receptor · Yingkui Yang · 2000 · 174 citations · Cited by this paper
  20. A Novel Approach to Interrogating Whole Genome Sequencing Data to Optimise Clinical Utility · 2026 · Related
  21. Patients with Obesity Caused by Melanocortin-4 Receptor Mutations Can Be Treated with a Glucagon-like Peptide-1 Receptor Agonist · Eva Winning Iepsen · 2018 · 154 citations · Cited by this paper
  22. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance · Agatha A. van der Klaauw · 2019 · 153 citations · Cited by this paper
  23. High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families · Sadia Saeed · 2012 · 93 citations · Cited by this paper
  24. Childhood Obesity: Position Statement of Polish Society of Pediatrics, Polish Society for Pediatric Obesity, Polish Society of Pediatric Endocrinology and Diabetes, the College of Family Physicians in Poland and Polish Association for Study on Obesity · Artur Mazur · 2022 · 54 citations · Cited by this paper
  25. Overexpression of melanocortin 2 receptor accessory protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure · Giuseppe Bruschetta · 2018 · 29 citations · Cited by this paper
  26. A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity · Vassos Neocleous · 2016 · 17 citations · Cited by this paper
  27. Case report: Nerve fiber regeneration in children with melanocortin 4 receptor gene mutation related obesity treated with semaglutide · Hoda Gad · 2024 · 10 citations · Cited by this paper

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