Research map: A bitter melon natural compound ameliorates the myotonic dystrophy type 1 skeletal muscle phenotype in a sex-specific manner

Back to the article

Papers in this map

  1. mTOR Signaling in Growth Control and Disease · Mathieu Laplante · 2012 · 8686 citations · Cited by this paper
  2. Huoling Shengji granule in amyotrophic lateral sclerosis: A multicenter, randomized, double-blind, riluzole-controlled trial · 2026 · Related
  3. Molecular basis of myotonic dystrophy: Expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member · J. David Brook · 1992 · 2808 citations · Cited by this paper
  4. PrPC modulates BACE1-dependent amyloid pathology under chronic cerebral hypoperfusion: Implications for vascular cognitive impairment · 2026 · Related
  5. Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases · Eléonore Beurel · 2014 · 1810 citations · Cited by this paper
  6. Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing · 2026 · Related
  7. Myotonic Dystrophy Mutation: an Unstable CTG Repeat in the 3′ Untranslated region of the Gene · Mani S. Mahadevan · 1992 · 1676 citations · Cited by this paper
  8. Identifying treatment-responsive patient subgroups in a neutral clinical trial of Intensive blood pressure reduction in acute intracerebral hemorrhage: A post hoc explainable machine learning analysis · 2026 · Related
  9. An Unstable Triplet Repeat in a Gene Related to Myotonic Muscular Dystrophy · Ying‐Hui Fu · 1992 · 1471 citations · Cited by this paper
  10. Electric muscle stimulation attenuates neuroinflammation and improves the outcome of acute ischemic stroke in mice · 2026 · Related
  11. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type · Eva R. Chin · 1998 · 1021 citations · Cited by this paper
  12. Bilateral intermittent theta burst stimulation over the primary motor cortex improves motor and affective symptoms via thalamic network reintegration in mid-stage Parkinson's disease · 2026 · Related
  13. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease · Vivek Panwar · 2023 · 961 citations · Cited by this paper
  14. Dual antiplatelet therapy in acute ischemic stroke: Does diabetes mellitus define a target population? · 2026 · Related
  15. Recruitment of human muscleblind proteins to (CUG)n expansions associated with myotonic dystrophy · Jill W. Miller · 2000 · 956 citations · Cited by this paper
  16. Sex-specific considerations in migraine therapy · 2026 · Related
  17. Myotonic Dystrophy in Transgenic Mice Expressing an Expanded CUG Repeat · Ami K. Mankodi · 2000 · 755 citations · Cited by this paper
  18. PEBP1 inhibition as a therapeutic target for neurological recovery in ischemic stroke · 2026 · Related
  19. Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues. · Krishan L. Taneja · 1995 · 606 citations · Cited by this paper
  20. Hemodynamics Beyond Ischemic Zone Underlies Early Neurological Deterioration in Minor Stroke with Large Vessel Occlusion · 2026 · Related
  21. Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery · Ngan Thi Thu Tran · 2020 · 547 citations · Cited by this paper
  22. Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons · Hong Ning Jiang · 2004 · 536 citations · Cited by this paper
  23. Failure of MBNL1-dependent post-natal splicing transitions in myotonic dystrophy · Xiaoyan Lin · 2006 · 520 citations · Cited by this paper
  24. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency · Baby Joseph · 2013 · 510 citations · Cited by this paper
  25. Muscleblind proteins regulate alternative splicing · Thai H. Ho · 2004 · 504 citations · Cited by this paper
  26. Expansion of a CUG trinucleotide repeat in the 3′ untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts · Brigid M. Davis · 1997 · 477 citations · Cited by this paper
  27. Increased Steady-State Levels of CUGBP1 in Myotonic Dystrophy 1 Are Due to PKC-Mediated Hyperphosphorylation · N. Muge Kuyumcu-Martinez · 2007 · 455 citations · Cited by this paper
  28. Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway · Min-Jia Tan · 2008 · 405 citations · Cited by this paper
  29. Myotonic Dystrophy · Charles A. Thornton · 2014 · 379 citations · Cited by this paper
  30. Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy · Hongqing Du · 2010 · 342 citations · Cited by this paper
  31. Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy · Charlotte Fugier · 2011 · 341 citations · Cited by this paper
  32. The myotonic dystrophies: diagnosis and management · Chloe Turner · 2010 · 330 citations · Cited by this paper
  33. Expanded CUG repeat RNAs form hairpins that activate the double-stranded RNA-dependent protein kinase PKR · Bin Tian · 2000 · 252 citations · Cited by this paper
  34. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes · J. Welihinda · 1986 · 230 citations · Cited by this paper
  35. Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat · I Ahmed · 1998 · 216 citations · Cited by this paper
  36. Antagonistic regulation of mRNA expression and splicing by CELF and MBNL proteins · Eric T. Wang · 2015 · 201 citations · Cited by this paper
  37. Compound loss of muscleblind‐like function in myotonic dystrophy · Kuang‐Yung Lee · 2013 · 197 citations · Cited by this paper
  38. DEMONSTRATION OF THE HYPOGLYCEMIC ACTION OF MOMORDICA CHARANTIA IN A VALIDATED ANIMAL MODEL OF DIABETES · Siddik Sarkar · 1996 · 185 citations · Cited by this paper
  39. Hypoglycemic Activity of the Fruit of the Momordica charantia in Type 2 Diabetic Mice. · Toshihiro Miura · 2001 · 172 citations · Cited by this paper

Source: OpenAlex (CC0)