Research map: The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal

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Papers in this map

  1. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine · Lindsey R. Baden · 2020 · 10909 citations · Cited by this paper
  2. Hilar mossy cell oxytocin receptor signaling regulates adult hippocampal neurogenesis and context discrimination in mice · 2026 · Related
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  9. Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability · Katalin Karikó · 2008 · 1958 citations · Cited by this paper
  10. A STING signaling relay from tumor cells to macrophages mediates the improved efficacy of combination chemotherapy in pancreatic cancer · 2026 · Related
  11. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness · Kizzmekia S. Corbett · 2020 · 1701 citations · Cited by this paper
  12. Calcium and phosphorylation coordination is a novel mechanism that stabilises protein-complexes during HIV assembly · 2026 · Related
  13. Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5 · Hiroki Kato · 2008 · 1614 citations · Cited by this paper
  14. Tumor-on-chip’s alliance with molecular pathology against metastatic disease · 2026 · Related
  15. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months · Stephen J. Thomas · 2021 · 1575 citations · Cited by this paper
  16. MPT0E028, a pan-HDAC inhibitor, ameliorates bleomycin-induced pulmonary fibrosis by promoting AT2-to-AT1 differentiation through the ATM/AMPK/FoxO1 pathway · 2026 · Related
  17. Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA · Katalin Karikó · 2011 · 915 citations · Cited by this paper
  18. OPRM1/MRGPRX1 heterodimers drive opioid-induced itch through a peripheral mechanism · 2026 · Related
  19. Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study · Jeffrey S. Weber · 2024 · 873 citations · Cited by this paper
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  21. N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice · Oliwia Andries · 2015 · 709 citations · Cited by this paper
  22. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation · Bart R. Anderson · 2010 · 699 citations · Cited by this paper
  23. mRNA Vaccine Delivery Using Lipid Nanoparticles · Andreas Michael Reichmuth · 2016 · 632 citations · Cited by this paper
  24. Opportunities and Challenges in the Delivery of mRNA-Based Vaccines · Abishek Wadhwa · 2020 · 591 citations · Cited by this paper
  25. A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA · Markus Baiersdörfer · 2019 · 587 citations · Cited by this paper
  26. Cellulose and the role of hydrogen bonds: not in charge of everything · Malin Bergenstråhle‐Wohlert · 2021 · 577 citations · Cited by this paper
  27. mRNA vaccines manufacturing: Challenges and bottlenecks · Sara Sousa Rosa · 2021 · 547 citations · Cited by this paper
  28. Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults · Eleanor M. P. Wilson · 2023 · 503 citations · Cited by this paper
  29. Algorithm for optimized mRNA design improves stability and immunogenicity · He Zhang · 2023 · 495 citations · Cited by this paper
  30. Asymmetric-flow field-flow fractionation technology for exomere and small extracellular vesicle separation and characterization · Haiying Zhang · 2019 · 487 citations · Cited by this paper
  31. Cellular origins of dsRNA, their recognition and consequences · Y. Grace Chen · 2021 · 471 citations · Cited by this paper
  32. Double-Stranded RNA Sensors and Modulators in Innate Immunity · Sun Hur · 2019 · 443 citations · Cited by this paper
  33. Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR · Arvin C. Dar · 2005 · 396 citations · Cited by this paper
  34. Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses · Yize Li · 2016 · 315 citations · Cited by this paper
  35. The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines · Pedro Morais · 2021 · 285 citations · Cited by this paper
  36. The TLR3 signaling complex forms by cooperative receptor dimerization · Joshua N. Leonard · 2008 · 284 citations · Cited by this paper
  37. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density · Yuri V. Svitkin · 2017 · 282 citations · Cited by this paper
  38. Lipid nanoparticles for delivery of RNA therapeutics: Current status and the role of in vivo imaging · Han Na Jung · 2022 · 276 citations · Cited by this paper
  39. An engineered T7 RNA polymerase that produces mRNA free of immunostimulatory byproducts · Athanasios D. Dousis · 2022 · 247 citations · Cited by this paper

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