Research map: The clinical evidence and strategic use of hyaluronidase in spinal interventions

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Papers in this map

  1. Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses · Ernst Johannes Menzel · 1998 · 346 citations · Cited by this paper
  2. Utility of the tympanic membrane temperature probe for continuous core temperature monitoring during general anesthesia: in vitro laboratory validation and prospective observational study · 2025 · Related
  3. Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administration · Gregory I Frost · 2007 · 324 citations · Cited by this paper
  4. Intraoperative lactate level and lactate clearance is associated with long-term mortality in liver transplant recipients · 2025 · Related
  5. Hyaluronidase: a review of approved formulations, indications and off-label use in chronic pain management · Amber L Dunn · 2009 · 122 citations · Cited by this paper
  6. From labor to surgery: expanding the role of programmed intermittent epidural bolus beyond obstetric · 2026 · Related
  7. Hyaluronidase Modulates Inflammatory Response and Accelerates the Cutaneous Wound Healing · Márcio Fronza · 2014 · 105 citations · Cited by this paper
  8. Utility of real-time ultrasound-guided spinal anesthesia in severe ankylosing spondylitis - A case report - · 2026 · Related
  9. Influence of lumbar epidural injection volume on pain relief for radicular leg pain and/or low back pain · Deborah L Rabinovitch · 2009 · 104 citations · Cited by this paper
  10. A prospective randomized study to evaluate the effect of epidural volume extension with normal saline in combined spinal epidural anesthesia for lower limb surgeries using intrathecal hyperbaric levobupivacaine · 2026 · Related
  11. Percutaneous Epidural Lysis of Adhesions in Chronic Lumbar Radicular Pain: A Randomized, Double-Blind, Placebo-Controlled Trial · Ludger Gerdesmeyer · 2013 · 103 citations · Cited by this paper
  12. Intercostal nerve cryoanalgesia in lung transplantation: a retrospective single-center study · 2026 · Related
  13. Epidural Lysis of Adhesions · Frank Lee · 2014 · 91 citations · Cited by this paper
  14. Prediction of postoperative desaturation and bradycardia in neonates undergoing laparoscopic inguinal hernia repair: a retrospective cohort study · 2026 · Related
  15. The Role of Adding Hyaluronidase to Fluoroscopically Guided Caudal Steroid and Hypertonic Saline Injection in Patients with Failed Back Surgery Syndrome: A Prospective, Double-Blinded, Randomized Study · Ayman Abd Al-Maksoud Yousef · 2010 · 56 citations · Cited by this paper
  16. Suspected remimazolam formulation-associated peri-induction anaphylaxis: two cases highlighting diagnostic complexity - Two case reports - · 2026 · Related
  17. Evolution of Epidural Lysis of Adhesions · Susan R. Anderson · 2000 · 52 citations · Cited by this paper
  18. Cervical facet joint interventions for neck pain: an anatomically and clinically focused review · 2025 · Related
  19. The Effect of Hyaluronidase in Interlaminar Lumbar Epidural Injection for Failed Back Surgery Syndrome · Sang Beom Kim · 2012 · 39 citations · Cited by this paper
  20. Anesthesia for uterine transplantation · 2026 · Related
  21. Hyaluronidases: A Therapeutic Enzyme · Naqab Khan · 2018 · 38 citations · Cited by this paper
  22. Epidural Lysis of Adhesions for Failed Back Surgery and Spinal Stenosis · Eugene Hsu · 2013 · 35 citations · Cited by this paper
  23. Hyaluronidase decreases neutrophils infiltration to the inflammatory site · Márcio Fronza · 2016 · 32 citations · Cited by this paper
  24. Effectiveness and Factors Associated with Epidural Decompression and Adhesiolysis Using a Balloon-Inflatable Catheter in Chronic Lumbar Spinal Stenosis: 1-Year Follow-Up · Seong-Soo Choi · 2015 · 28 citations · Cited by this paper
  25. The Additional Effect of Hyaluronidase in Lumbar Interlaminar Epidural Injection · Sang Beom Kim · 2011 · 27 citations · Cited by this paper
  26. Delayed allergic hypersensitivity to hyaluronidase during the treatment of granulomatous hyaluronic acid reactions · Lin Chi Wu · 2017 · 25 citations · Cited by this paper
  27. A Randomized, Multicenter, Double-Blind, Parallel Pilot Study Assessing the Effect of Mechanical Adhesiolysis vs Adhesiolysis with Corticosteroid and Hyaluronidase Administration into the Epidural Space During Epiduroscopy · Róbert Rapčan · 2017 · 24 citations · Cited by this paper
  28. Anaphylactic Shock Caused by the Epidurally-Administered Hyalurinidase · Haekwang Lee · 2011 · 23 citations · Cited by this paper
  29. An Evaluation of Medications Commonly Used for Epidural Neurolysis Procedures in a Human Fibroblast Cell Culture Model · Christof Birkenmaier · 2011 · 22 citations · Cited by this paper
  30. A Retrospective Study to Evaluate the Effect of Concentration of Hypertonic Saline on Efficacy and Safety of Epidural Adhesiolysis · Eun Joo Choi · 2017 · 22 citations · Cited by this paper
  31. Hyaluronidase in the management of pain due to post-laminectomy scar tissue · P. Borg · 1994 · 21 citations · Cited by this paper
  32. Immunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation · Priscilla Aparecida Tártari Pereira · 2019 · 21 citations · Cited by this paper
  33. Allergic Complications of Hyaluronidase Injection: Risk Factors, Treatment Strategies, and Recommendations for Management · Günel Guliyeva · 2023 · 18 citations · Cited by this paper
  34. Hyaluronidase in Neuroplasty: A Review · Standiford Helm · 2019 · 16 citations · Cited by this paper
  35. Randomized Controlled Study of Percutaneous Epidural Neuroplasty Using Racz Catheter and Epidural Steroid Injection in Cervical Disc Disease · Dong Ah Shin · 2016 · 15 citations · Cited by this paper
  36. An industry perspective on hyaluronidase co-formulated biopharmaceutics · Jeremy Guo · 2025 · 15 citations · Cited by this paper
  37. A Review of the Role of Epidural Percutaneous Neuroplasty · Standiford Helm · 2018 · 13 citations · Cited by this paper
  38. Comparison of the Effect of Bicarbonate, Hyaluronidase, and Lidocaine Injection on Myofascial Pain Syndrome · Mahshid Ghasemi · 2020 · 13 citations · Cited by this paper
  39. Comparative effectiveness of paravertebral Ozone injection and caudal epidural steroid-hyaluronidase injection in lumbosacral spinal stenosis · Reyhaneh Parvin · 2021 · 13 citations · Cited by this paper

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