Research map: Glial cell toxicity in a Drosophila C9orf72 neurodegeneration model

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Papers in this map

  1. Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS · Mariely DeJesus‐Hernandez · 2011 · 5078 citations · Cited by this paper
  2. Multiple instance fine-mapping: Predicting causal regulatory variants with a deep sequence model · 2026 · Related
  3. A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD · Alan Edward Renton · 2011 · 4552 citations · Cited by this paper
  4. Multi-ancestry colocalization approaches · 2026 · Related
  5. Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis · Shuo‐Chien Ling · 2013 · 1890 citations · Cited by this paper
  6. Lysosome-related organelles employ divergent mechanisms to modulate cytosolic zinc homeostasis · 2026 · Related
  7. The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS · Kohji Mori · 2013 · 1328 citations · Cited by this paper
  8. Towards a unified model of aneuploid karyotype dynamics · 2026 · Related
  9. A connectome and analysis of the adult Drosophila central brain · Louis K. Scheffer · 2020 · 1267 citations · Cited by this paper
  10. Correlated protein-RNA associations and a requirement for HNRNPU in the long-range recruitment of Polycomb Repressive Complexes by the lncRNAs Airn and Kcnq1ot1 · 2026 · Related
  11. RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention · Christopher J. Donnelly · 2013 · 897 citations · Cited by this paper
  12. Chromatin insulators homie and nhomie can interact with distant copies either together or separately, with distinct outcomes for enhancer-promoter interactions · 2026 · Related
  13. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport · Brian D. Freibaum · 2015 · 888 citations · Cited by this paper
  14. A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity · 2026 · Related
  15. Spreading of pathology in neurodegenerative diseases: a focus on human studies · Johannes Brettschneider · 2015 · 812 citations · Cited by this paper
  16. Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum · 2026 · Related
  17. Astrocytes from familial and sporadic ALS patients are toxic to motor neurons · Amanda M. Haidet-Phillips · 2011 · 795 citations · Cited by this paper
  18. Cold-responsive interaction between MdRAD23D1 and MdMYB15 confers cold stress tolerance via the CBF pathway in apple (Malus domestica) · 2026 · Related
  19. ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now? · Rita Mejzini · 2019 · 789 citations · Cited by this paper
  20. Cross-family and phage-specific gene requirements for Klebsiella infection revealed by scalable RB-TnSeq genetic screens · 2026 · Related
  21. C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins · Sarah Mizielinska · 2014 · 784 citations · Cited by this paper
  22. C9orf72-mediated ALS and FTD: multiple pathways to disease · Rubika Balendra · 2018 · 758 citations · Cited by this paper
  23. Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS · Tania F. Gendron · 2013 · 609 citations · Cited by this paper
  24. Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death · Xinmei Wen · 2014 · 570 citations · Cited by this paper
  25. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration · Clotilde Lagier‐Tourenne · 2013 · 569 citations · Cited by this paper
  26. Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons · Rodrigo Lopez-Gonzalez · 2016 · 441 citations · Cited by this paper
  27. Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS · Mercedes Prudencio · 2015 · 419 citations · Cited by this paper
  28. Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS · Diane Bérangère Ré · 2014 · 413 citations · Cited by this paper
  29. Cell Killing by the Drosophila Gene reaper · Kristin White · 1996 · 398 citations · Cited by this paper
  30. Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72 · Johnathan Cooper‐Knock · 2012 · 341 citations · Cited by this paper
  31. C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci · Sarah Mizielinska · 2013 · 340 citations · Cited by this paper
  32. Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis · Sorana Ciura · 2013 · 338 citations · Cited by this paper
  33. Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis · Renée N. Douville · 2010 · 335 citations · Cited by this paper
  34. Focality of upper and lower motor neuron degeneration at the clinical onset of ALS · John Ravits · 2007 · 325 citations · Cited by this paper
  35. The glia of the adult D rosophila nervous system · Malte C. Kremer · 2017 · 323 citations · Cited by this paper
  36. Cellular Senescence in Brain Aging · Ewa Sikora · 2021 · 305 citations · Cited by this paper
  37. Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS · Lisa Krug · 2017 · 217 citations · Cited by this paper
  38. The neuropathology associated with repeat expansions in the C9ORF72 gene · Ian R. Mackenzie · 2013 · 216 citations · Cited by this paper
  39. Astrocytes carrying the superoxide dismutase 1 (SOD1 G93A ) mutation induce wild-type motor neuron degeneration in vivo · Sophia T. Papadeas · 2011 · 214 citations · Cited by this paper

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