Research map: Xanthohumol and its non-estrogenic derivatives link to the gut-liver-brain axis to improve cognition in mice with diet-induced obesity

Papers in this map

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15. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3 · Francesco Beghini · 2021 · 2439 citations · Cited by this paper
16. Growth, physiological, antioxidants, and immune response of heteroclarias catfish fingerlings, to dietary Moringa oleifera leaves extract and its susceptibility to Aeromonas hydrophila infection · 2026 · Related
17. Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance · William L. Holland · 2007 · 1238 citations · Cited by this paper
18. Exercise triggers integrated lipid, sphingolipid and purine metabolic alterations in midlife women · 2026 · Related
19. Interaction between drugs and the gut microbiome · Rinse Karel Weersma · 2020 · 972 citations · Cited by this paper
20. Inactivation of interleukin-15 reduces spontaneous atherosclerosis in apolipoprotein E-deficient mice · 2026 · Related
21. Ceramides in insulin resistance and lipotoxicity · Scott A. Summers · 2005 · 851 citations · Cited by this paper
22. Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance · Sarah M. Turpin-Nolan · 2014 · 701 citations · Cited by this paper
23. Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction · Changtao Jiang · 2015 · 556 citations · Cited by this paper
24. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets · Joshua S. Fleishman · 2024 · 538 citations · Cited by this paper
25. Ceramides as modulators of cellular and whole-body metabolism · Benjamin T. Bikman · 2011 · 420 citations · Cited by this paper
26. A Comprehensive Review: Sphingolipid Metabolism and Implications of Disruption in Sphingolipid Homeostasis · Brianna M. Quinville · 2021 · 352 citations · Cited by this paper
27. The Prenylflavonoid Isoxanthohumol from Hops (Humulus lupulus L.) Is Activated into the Potent Phytoestrogen 8-Prenylnaringenin In Vitro and in the Human Intestine · Sam Possemiers · 2006 · 260 citations · Cited by this paper
28. Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota · Anna E. Lindell · 2022 · 229 citations · Cited by this paper
29. An Intestinal Farnesoid X Receptor–Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice · Cen Xie · 2016 · 203 citations · Cited by this paper
30. Inositols in Insulin Signaling and Glucose Metabolism · Arturo Bevilacqua · 2018 · 175 citations · Cited by this paper
31. D-chiro-inositol metabolism in diabetes mellitus. · Richard E. Ostlund · 1993 · 133 citations · Cited by this paper
32. How bile acids and the microbiota interact to shape host immunity · Michael Hweemoon Lee · 2024 · 132 citations · Cited by this paper
33. Polyunsaturated Fatty Acids Are FXR Ligands and Differentially Regulate Expression of FXR Targets · Annie Zhao · 2004 · 123 citations · Cited by this paper
34. Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift · Deep Chanda · 2024 · 107 citations · Cited by this paper
35. Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice · Cristobal L. Miranda · 2016 · 103 citations · Cited by this paper
36. Strong antimicrobial activity of xanthohumol and other derivatives from hops ( Humulus lupulus L.) on gut anaerobic bacteria · Pavel Čermák · 2017 · 96 citations · Cited by this paper
37. Lipopolysaccharide-induced ischemic tolerance is associated with increased levels of ceramide in brain and in plasma · Carolin Zimmermann · 2001 · 92 citations · Cited by this paper
38. Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice · Cristobal L. Miranda · 2018 · 77 citations · Cited by this paper
39. Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism · Yang Zhang · 2019 · 67 citations · Cited by this paper

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