Research map: Cytokine-mediated immune-to-brain signaling in neural circuit disorders

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  1. From inflammation to sickness and depression: when the immune system subjugates the brain · Robert Dantzer · 2007 · 7443 citations · Cited by this paper
  2. METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis · 2026 · Related
  3. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases · Rebecca C. Coll · 2015 · 2897 citations · Cited by this paper
  4. Decoding spontaneous intracerebral hemorrhage: mechanistic breakthroughs and disruptive revolution in pharmacological treatment · 2026 · Related
  5. IL-6 as a keystone cytokine in health and disease · Christopher A. Hunter · 2015 · 2556 citations · Cited by this paper
  6. Metastasis-related genomic aberrations and evolutionary trajectory in uveal melanoma · 2026 · Related
  7. Overview of the IL ‐1 family in innate inflammation and acquired immunity · Charles Anthony Dinarello · 2017 · 1922 citations · Cited by this paper
  8. Coordinated DNA 5-mC and RNA m5C methylation epigenetically regulates MZF1 splice variants to drive EGFR-TKI resistance · 2026 · Related
  9. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases · Charles Anthony Dinarello · 2012 · 1789 citations · Cited by this paper
  10. Cannabidiol triggers fatty acids β-oxidation mediated by Stat2 to facilitate intestinal stem cells regeneration post radiation · 2026 · Related
  11. Synaptic scaling mediated by glial TNF-α · David Stellwagen · 2006 · 1730 citations · Cited by this paper
  12. RUNX1 recruitment of GCN5 in keratinocytes upregulates ICOSLG and promotes T cell activation in the psoriasis microenvironment · 2026 · Related
  13. A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression · Charles L. Raison · 2012 · 1618 citations · Cited by this paper
  14. Dynamics, function, and regulation of mammary stem cells in development and disease · 2026 · Related
  15. The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing · Sarah L. Gaffen · 2014 · 1586 citations · Cited by this paper
  16. CPT1B K321 crotonylation contributes to cardiac dysfunction in endotoxic shock · 2026 · Related
  17. The IL-17 Family of Cytokines in Health and Disease · Mandy J. McGeachy · 2019 · 1487 citations · Cited by this paper
  18. The role of microglia in early neurodevelopment and the effects of maternal immune activation · 2024 · Related
  19. Molecular mechanisms regulating NLRP3 inflammasome activation · Eun‐Kyeong Jo · 2015 · 1409 citations · Cited by this paper
  20. Microglia in systemic neuroimmune communication: functions beyond phagocytosis · 2026 · Related
  21. The P2X7 Receptor in Infection and Inflammation · Francesco Di Virgilio · 2017 · 1300 citations · Cited by this paper
  22. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring · Gloria B. Choi · 2016 · 1282 citations · Cited by this paper
  23. Maternal immune activation: Implications for neuropsychiatric disorders · Myka L. Estes · 2016 · 1259 citations · Cited by this paper
  24. The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease · Alexander H. Stephan · 2012 · 1167 citations · Cited by this paper
  25. INTERLEUKIN-1 RECEPTOR ANTAGONIST: Role in Biology · William P. Arend · 1998 · 1094 citations · Cited by this paper
  26. The anatomical and cellular basis of immune surveillance in the central nervous system · Richard M. Ransohoff · 2012 · 999 citations · Cited by this paper
  27. Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases · Barbara Viviani · 2003 · 875 citations · Cited by this paper
  28. Microglia Heterogeneity in the Single-Cell Era · Takahiro Masuda · 2020 · 852 citations · Cited by this paper
  29. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development · Ilia D. Vainchtein · 2018 · 677 citations · Cited by this paper
  30. Microglial regional heterogeneity and its role in the brain · Yunlong Tan · 2019 · 615 citations · Cited by this paper
  31. Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression · Haixia Wang · 2022 · 581 citations · Cited by this paper
  32. Targeting IL-6 trans-signalling: past, present and future prospects · Stefan Rose‐John · 2023 · 526 citations · Cited by this paper
  33. The role of interleukin-6 signaling in nervous tissue · Michelle Rothaug · 2016 · 518 citations · Cited by this paper
  34. Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons · Kalil Alves de Lima · 2020 · 434 citations · Cited by this paper
  35. Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders · Urtė Neniškytė · 2017 · 339 citations · Cited by this paper
  36. IL-17a promotes sociability in mouse models of neurodevelopmental disorders · Michael Douglas Reed · 2019 · 298 citations · Cited by this paper
  37. The blood-brain barrier in neuroimmunology: Tales of separation and assimilation · William A. Banks · 2014 · 288 citations · Cited by this paper
  38. Role of IL-6 in the regulation of neuronal development, survival and function · Kai K. Kummer · 2021 · 284 citations · Cited by this paper
  39. IL-6 regulation of synaptic function in the CNS · Donna L. Gruol · 2014 · 256 citations · Cited by this paper

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