Research map: Assessing the Role of Model Complexity in Virtual Clinical Trial Outcomes

Back to the article

Papers in this map

  1. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) · E. A. Eisenhauer · 2008 · 30146 citations · Cited by this paper
  2. Topological Structure of Epigenetic Forests in Flower Morphogenesis · 2026 · Related
  3. Multimodel Inference · Kenneth P. Burnham · 2004 · 11880 citations · Cited by this paper
  4. Coupled SDE-ODE Modeling of Tumor-Immune Dynamics to Infer Biomarker Release · 2026 · Related
  5. Bayesian model averaging: a tutorial (with comments by M. Clyde, David Draper and E. I. George, and a rejoinder by the authors · Jennifer A. Hoeting · 1999 · 4197 citations · Cited by this paper
  6. Uncertainty and Sensitivity Analysis of Hair Growth Duration in Human Scalp Follicles Under Normal and Alopecic Conditions · 2026 · Related
  7. A metric for distributions with applications to image databases · Yossi Rubner · 2002 · 1768 citations · Cited by this paper
  8. Personalized Spatiotemporal Radiotherapy for GBM: A PDE-Constrained Optimization Study · 2026 · Related
  9. Approximate Bayesian computation scheme for parameter inference and model selection in dynamical systems · Tina Toni · 2008 · 1628 citations · Cited by this paper
  10. A Cost-Sensitive Behavioral Modeling Analysis of the Early Identification and Control of Infectious Diseases · 2026 · Related
  11. Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood · Andreas Raue · 2009 · 1513 citations · Cited by this paper
  12. Damage-Driven Irreversibility and Emergent Senescence in Age–Structured Cell Populations · 2026 · Related
  13. Markov chain Monte Carlo simulation using the DREAM software package: Theory, concepts, and MATLAB implementation · Jasper Alexander Vrugt · 2015 · 896 citations · Cited by this paper
  14. Global Stability Analysis of a Mathematical Model for the “Shock-and-Kill" Strategy in HIV-1/SIV Brain Infection · 2026 · Related
  15. Sensitivity and specificity of information criteria · John J. Dziak · 2019 · 721 citations · Cited by this paper
  16. A Dual-age Structured Epidemiological Model with Waning Immunity and Reinfection · 2026 · Related
  17. Models in biology: ‘accurate descriptions of our pathetic thinking’ · Jeremy Gunawardena · 2014 · 265 citations · Cited by this paper
  18. Modeling the effects of vector species composition and temperature on the risk of dengue virus · 2026 · Related
  19. Virtual clinical trials in medical imaging: a review · Ehsan Abadi · 2020 · 228 citations · Cited by this paper
  20. The Exact Hypergeometric Posterior Method for Accurate Inference of Population Size from Mark–Recapture Data · 2026 · Related
  21. Efficient Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models · RJ Allen · 2016 · 192 citations · Cited by this paper
  22. Modeling of cancer virotherapy with recombinant measles viruses · Željko Bajzer · 2008 · 172 citations · Cited by this paper
  23. Methods of Model Reduction for Large-Scale Biological Systems: A Survey of Current Methods and Trends · Thomas J. Snowden · 2017 · 166 citations · Cited by this paper
  24. Oncolytic viruses: how “lytic” must they be for therapeutic efficacy? · María Eugenia Dávola · 2019 · 152 citations · Cited by this paper
  25. ODE models for oncolytic virus dynamics · Natalia L. Komarova · 2010 · 129 citations · Cited by this paper
  26. Therapeutic and Tumor-specific Immunity Induced by Combination of Dendritic Cells and Oncolytic Adenovirus Expressing IL-12 and 4-1BBL · Jing-Hua Huang · 2009 · 127 citations · Cited by this paper
  27. Towards Predictive Computational Models of Oncolytic Virus Therapy: Basis for Experimental Validation and Model Selection · Dominik Wodarz · 2009 · 102 citations · Cited by this paper
  28. A QSP Model for Predicting Clinical Responses to Monotherapy, Combination and Sequential Therapy Following CTLA-4, PD-1, and PD-L1 Checkpoint Blockade · Oleg Milberg · 2019 · 102 citations · Cited by this paper
  29. Improving the generation and selection of virtual populations in quantitative systems pharmacology models · Theodore R. Rieger · 2018 · 100 citations · Cited by this paper
  30. Oncolytic virotherapy in cancer treatment: challenges and optimization prospects · Lingjuan Chen · 2023 · 89 citations · Cited by this paper
  31. Alternate virtual populations elucidate the type I interferon signature predictive of the response to rituximab in rheumatoid arthritis · Brian James Schmidt · 2013 · 79 citations · Cited by this paper
  32. From Benchtop to Bedside: A Review of Oncolytic Virotherapy · Audrey H. Choi · 2016 · 74 citations · Cited by this paper
  33. Stochastic Virtual Population of Subjects With Type 1 Diabetes for the Assessment of Closed-Loop Glucose Controllers · Ahmad Haidar · 2013 · 71 citations · Cited by this paper
  34. Determinants of combination GM-CSF immunotherapy and oncolytic virotherapy success identified through in silico treatment personalization · Tyler Cassidy · 2019 · 68 citations · Cited by this paper
  35. A mathematical model for cell cycle-specific cancer virotherapy · Joseph J. Crivelli · 2011 · 64 citations · Cited by this paper
  36. Mathematical modeling of within‐host Zika virus dynamics · Katharine Best · 2018 · 61 citations · Cited by this paper
  37. Integrating Epidemiological Data into a Mechanistic Model of Type 2 Diabetes: Validating the Prevalence of Virtual Patients · David J. Klinke · 2007 · 56 citations · Cited by this paper
  38. Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics · Peter Kim · 2015 · 55 citations · Cited by this paper
  39. Evaluating optimal therapy robustness by virtual expansion of a sample population, with a case study in cancer immunotherapy · Syndi Barish · 2017 · 55 citations · Cited by this paper

Source: OpenAlex (CC0)